HLA Polymorphism in Israel: 2. Israeli Jews originating from Russia

Bukharan and Georgian Jews have lived in central Asia for many centuries. Approximately 30,000 Bukharan and 37,000 Georgian Jews lived in their respective countries within the USSR between 1920 and 1960. Genetic markers of blood--blood groups, isoenzymes, HLA antigens, and gamma and kappa chain allotypes--were tested in blood samples from 113 Bukharan and 134 Georgian Jews living in Israel. Estimates of inbreeding were low: alpha = 0.0088 for Bukharan and alpha = 0.0011 for Georgian Jews. G6PD deficiency was relatively rare in Bukharan (2.2%) and in Georgian Jews (6.0%), when compared to other Jews in the area. Both populations showed frequencies of some markers similar to that of other Jewish populations, but frequencies of several markers were extremely high or low. Bukharan Jews showed very high frequencies of B(0.243), cDe (0.122), JkA (0.705), HLA-A29 (0.167), A30 (0.116) and B7 (0.124), and AcPA (0.451) and very low ones of O(0.518), CDe(0.422), AcPB (0.513) and GLO1 (0.140). Very high frequencies in Georgian Jews were observed for cDE (0.189), HLA-A3 (0.194), Bw35 (0.300) and GLO1 (0.367). Yet the greatest difference between both populations was in African characters. While in Bukharan Jews Fy was very frequent (0.146) and cDe was the highest observed among Jews (0.122), neither of these markers was detected among the Georgian Jews tested. Yet, another African character, the Gm1,5,10,11,13,14,17,26 haplotype, occurred in both populations (0.028 and 0.042 in Bukharan and Georgian Jews, respectively). Distance measures for Bukharan, Georgian, Iranian, Cochin, and Libyan Jews based on 13 polymorphic loci showed the greatest distance between Cochin Jews and the other populations and the smallest distance between the Georgian and Iranian Jews.

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Genetic polymorphisms among Bukharan and Georgian Jews in Israel

Levene¹,

Steinberg

Friedlander

et al. 1984

Am. J. Med. Genet.

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The relationship between HLA antigens and Bermuda grass hayfever

et al. 1978

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Associations between atopic diseases and lymphocyte antigens seem to be possible, but not certain (for a review see McMichael and McDevitt 1977). Several studies (Levine et al. 1972, Marsh et al. 1973, Yoo et al. 1976, Bruce et al. 1976, Scholtz et al. 1976, Seignalet et al. 1976, Marsh and Bias 1977 have shown a certain association between atopy and different HLA antigens or haplotypes, within the same family, but without demonstrating a definite association with one specific antigen or haplotype. Rachelefsky and coworkers (1976) found a strong association between atopic asthma and B lymphocyte group 2, which was not paralleled by an association with the HLA complex. Since hayfever is the classical, representative atopic disease, we present here the HLA typing of 141 patients suffering from Bermuda grass hayfever. These patients comprise two groups: 86 of them were studied during the 1975 season; 65 during the 1976 season; and 10 during both seasons. The diagnosis of hayfever was based on a positive correlation between: (a) family history (several cases of proven atopy in three consecutive generations); (b) clinical picture (seasonal rhinitis, conjunctivitis, and asthma during the Bermuda grass blooming season only); and (c) positive skin tests to whole Bermuda grass extract, obtained from the Hollister-Stier Laboratory. The controls were pooled from data on a recently typed healthy Jewish population (Brautbar et al. 1977, Gazit et al. 1978a, b, c, Zamir et al. 1978) so as to match the stratification of the patients into individuals of Ashkenazi (Russia, Poland, and Roumania) and Sephardic (Marocco and Iraq) origin, in a total of 597 controls for 65 patients.For HLA typing the standard N.I.H. technique was employed (Brand et aL 1970) and the lymphocytes were typed for 9 and 16 antigens at locus A and B, respectively, with 120 alloantisera obtained from the N.I.H. serum bank and from local preparations. The results in both groups (1975 and 1976) show an association with allele B27, at a significance of 1%, and this suggests more than a spurious correlation.The data were subjected to a relative risk analysis. The Haldane (1955) relative risk evaluation uses the formula:

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HLA‐D locus in Israel. Characterization of 14 local HTC's and a population study

et al. 1982

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Fourteen homozygous typing cells identified in Israel are described. Of these typing cells two were of Ashkenazi and 11 of non-Ashkenazi origin, while the remaining HTC was from an Arab donor. Ten of the 14 HTCs characterized in this manner were offspring of consanguineous marriages; all of them were non-Ashkenazim. Nine HTCs express specificities previously recognized in Caucasians, 4 HTCs represent new specificities (JI-J4), and one typing cell was found to be analogous to the Japanese Dw12 (DHO) specificity. The distribution of HLA-D specificities in 120 randomly selected Israelis representing the two main Jewish subpopulations, Ashkenazim and non-Ashkenazim, was studied with the locally defined HTCs. HLA-Dw5 and DwlO were found to be significantly increased while Dw2 and Dw6 were significantly decreased in Israelis as compared to Caucasians.

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HLA Polymorphism in Israel: 2. Israeli Jews originating from Russia

Cited by 4 publications

References 3 publications

Genetic polymorphisms among Bukharan and Georgian Jews in Israel

Genetic polymorphisms among Bukharan and Georgian Jews in Israel

The relationship between HLA antigens and Bermuda grass hayfever

HLA‐D locus in Israel. Characterization of 14 local HTC's and a population study

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