HLA polymorphisms in Saudi Arabs

Ollier, William; Doyle, P; Alonso, Antônio; Awad, J.; Williams, E. J.; Gill, Davinder; Welch, S.G.; Klouda, P. T.; Bacchus, Robby; Festenstein, H.

doi:10.1111/j.1399-0039.1985.tb00420.x

Cited by 19 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…42 The major limitation of this study was that our cases and controls showed higher than expected homozygote typing. A phenomenon that was described in the past 46 and might be due to high consanguinity in the Saudi population. The percentage of consanguinity in our study group was 57% (data not shown).…”

Section: Discussionmentioning

confidence: 99%

HLA class II polymorphism in Saudi patients with multiple sclerosis

Jumah

Kojan

Shehri

et al. 2017

HLA

View full text Add to dashboard Cite

Several studies have investigated the association of different HLA antigens with multiple sclerosis (MS). However, only few studies have considered the association of high‐resolution HLA type and MS with none yet from Saudi Arabia. The aim of this study was to investigate the association of HLA class II alleles with MS in the Saudi population. We used next‐generation sequencing to investigate HLA association with MS. This study was conducted at King Abdulaziz Medical City in Riyadh, Saudi Arabia. We found that several HLA‐DRB1 and DQB1 alleles were associated with MS. These alleles included HLA‐DRB1*15:01 (odds ratio [OR]: 3.01; 95%, confidence interval [CI]: 1.68‐5.54; P = .0001), HLA‐DQB1*02:01 (OR: 1.76; 95% CI: 1.20‐2.58; P = .0022), HLA‐DQB1*06:02 (OR: 3.52; 95% CI: 1.87‐6.86; P < .0001), and HLA‐DQB1*06:03 (OR: 2.42; 95% CI: 1.16‐5.25; P = 0.01). Interestingly, HLA‐DRB1*15:01 was associated with increased risk of previous relapses. In addition, HLA‐DRB1*15:01 and HLA‐DQB1*06:02 were found to be associated with lower vitamin D levels. This study provides insights on the association of different HLA alleles with clinical characteristics and outcome of MS among Saudis. These insights can have future implications for the clinical management of MS based on the patient genetic profile.

show abstract

Section: Discussionmentioning

confidence: 99%

HLA class II polymorphism in Saudi patients with multiple sclerosis

Jumah

Kojan

Shehri

et al. 2017

HLA

View full text Add to dashboard Cite

show abstract

“…This is the first report to show protective effect of HLA‐B*50, which was the most frequent allele in our population. HLA‐B*50 is absent or rarely found in other populations (Middleton et al ., 2003) but was reported earlier by Ollier et al . (1985) to be highly frequent in the Saudi population.…”

Section: Discussionmentioning

confidence: 99%

HLA class I and class II polymorphisms in Saudi patients with myasthenia gravis

Hajeer

Sawidan

Bohlega

et al. 2009

Int J Immunogenetics

View full text Add to dashboard Cite

Myasthenia gravis (MG) is a rare autoimmune disease of the neuromuscular junction. MG has been shown to be associated with many HLA antigens in different populations. Here we have analysed the frequency of HLA-A, B, DR and DQ in a group of Saudi MG patients and compared their results to a group of healthy controls. MG in Saudi patients is found to be associated with HLA-A*23, B*08, B*18, DRB1*16 and DRB1*13. The strongest association was with HLA-B*08, which was associated with young age at onset and female gender. Our results are in line with other published results from around the world and warrant fine mapping of the area using microsatellite to map the disease gene.

show abstract

“…Comparisons of the HLA antigen frequencies in Tunisians with other Arab populations are also summarized in Table 2. These comparisons are limited to studies of Saudi Arabs (Ollier et al 1985). Kabyle population in Algeria (Bouali et al 1981).…”

Section: Discussionmentioning

confidence: 99%

HLA‐A,B,C and DR antigens in a sample of the Tunisian population

et al. 1987

View full text Add to dashboard Cite

The HLA-A, B and DR phenotypes of 109 unrelated Tunisian individuals have been determined. The HLA-A and B antigen frequencies were compared with data reported for European Caucasoids and various Arab populations.Most similarities in antigen frequencies were seen between Tunisians and Kabyles from North Africa. A high frequency of HLA-A23 and HLA-BwSO was observed in Tunisians and all Arab populations. A very close similarity in HLA-DR antigen frequencies exists between Tunisians and European Caucasoids. Linkage disequilibria between alleles of HLA loci were examined; many instances of previously reported antigen associations were seen in Tunisians, together with a number o , f associations which have not been described elsewhere. Aw34B8 and A2DRw14 are suggested as being common haplotypes in Tunisians.

show abstract

HLA polymorphisms in Saudi Arabs

Cited by 19 publications

References 15 publications

HLA class II polymorphism in Saudi patients with multiple sclerosis

HLA class II polymorphism in Saudi patients with multiple sclerosis

HLA class I and class II polymorphisms in Saudi patients with myasthenia gravis

HLA‐A,B,C and DR antigens in a sample of the Tunisian population

Contact Info

Product

Resources

About