HLA Typing and Affective Disorders: a Study in the Italian Population

Smeraldi, Enrico; Negri, F.; Melica, A. M.; Scorza-Smeraldi, R.; Gavarini, Fabio; Bonara, Paola; Bellodi, Laura; Sacchetti, Emilio; Sabbadini-Villa, M G; Cazzullo, C. L.; Zanussi, C

doi:10.1159/000117650

Cited by 25 publications

(13 citation statements)

References 6 publications

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“…This is similar with the results of Smeraldi et al. 7 Although the statistical significance was marginal ( P = 0.051), there was a tendency for greater A3 frequency in patients with bipolar disorder, which could support the results of the study of Shapiro et al. 20 Smeraldi et al.…”

Section: Discussionsupporting

confidence: 90%

“… 20 Smeraldi et al. reported that B22, being further divided into B54 and B55, had a greater frequency in patients with primary affective disorder 7 . In the present study, a greater B54 and lesser B51 frequency was found in the bipolar patient group before Bonferroni correction.…”

Section: Discussionsupporting

confidence: 47%

“…6 found that HLA‐A10 was frequent in patients with primary affective disorder, but this was not the case in the study of Smeraldi et al. 7 With regard to the strong affinity of this complex with neuroleptic drugs, especially sulpiride and haloperidol, increased expression of this antigen in patients taking these drugs 4 and in patients with schizophrenia 8 has been suggested. Moreover, studies investigating two locus haplotypes did not obtain consistent results 9,10 …”

Section: Introductionmentioning

confidence: 97%

“…Regarding HLA-A10, some have reported that it was higher in patients with bipolar disorder, 3,4 whereas others have shown that HLA-A10 is greater in patients with unipolar affective disorder. 5 In addition, Bersani et al 6 found that HLA-A10 was frequent in patients with primary affective disorder, but this was not the case in the study of Smeraldi et al 7 With regard to the strong affinity of this complex with neuroleptic drugs, especially sulpiride and haloperidol, increased expression of this antigen in patients taking these drugs 4 and in patients with schizophrenia 8 has been suggested. Moreover, studies investigating two locus haplotypes did not obtain consistent results.…”

Section: Introductionmentioning

confidence: 99%

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Human leukocyte antigen alleles in patients with bipolar disorder in the Korean population

Jun¹,

Pae²,

Chae³

et al. 2002

Psychiatry Clin Neurosci

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We performed an association study between human leukocyte antigen (HLA) alleles and bipolar disorder to evaluate the potentiality of HLA as a genetic marker in bipolar disorder. HLA class I and class II allele frequencies were assessed in 87 bipolar patients and were compared with those of 206 normal controls in the Korean population. HLA class I typing was performed using the microlymphocytotoxicity method, whereas class II (DRB1 and DQB1) genotyping was performed with polymerase chain reaction-sequence specific oligonucleotide probes. When the allele frequency of HLA in bipolar patients was compared with that in normal controls, there were some significant differences. Bipolar patients showed statistically significant increased allele frequencies of HLA-A29 and B54. Allele frequencies of HLA-B51 and DRB1*02 were significantly higher in normal controls. However, these results were no longer significant after correcting for the number of alleles. The results of the present study suggest that HLA alleles may not confer susceptibility to bipolar disorder in the Korean population. To clarify the genetic influence of HLA on bipolar disorder, we should conduct a consecutive study with a larger cohort of subjects.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Human leukocyte antigen alleles in patients with bipolar disorder in the Korean population

Jun¹,

Pae²,

Chae³

et al. 2002

Psychiatry Clin Neurosci

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show abstract

“…These methods do not properly account for multigenerational information or for variable penetrance or for ascertainment through color blind Bipolar males, although the computa- , and reeent re ports have not supported the presence of any association (Temple et. al., 1979;Smeraldi, 1978;Beckman et. al., 1978).…”

Section: Studies O[ Chromosomallinkage In Bipolar Manic-depressivmentioning

confidence: 99%

Genetic Studies of Manic-depressive lllness*

Es¹

1980

Pharmacopsychiatry

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The Unipolar (UP) and Bipolar (BP) forms of affective illness appear not to be genetically and physiologically identical, although the degree of overlap in family and biologic pharmacologic studies is considerable. It appears likely that at least a subgroup of UP illness shares its genetic diathesis with BP illness. The hypothesis of monoamine alterations associated with the affective illnesses has led to studies of genetics of enzymes of monoamine metabolism as observed in peripheral blood, erythrocyte catechol-O-methyl-transferase (COMT), platelet monoamine oxidase (MAO), and plasma dopamine-beta-hydroxylase (DBH). These are under genetic control and show some differences between patients with affective illness and controls, but these differences have not been consistently propagated through families along with the disorder. Linkage of BP illness to markers on the X-chromosome has been reported, but the evidence has internal inconsistencies which must be resolved before the phenomenon can be accepted. Association of BP illness with specific HLA types has also been reported, but efforts at replication have been unsuccessful. Mathematical models of transmission applied to family study data do not consistently support the same mode of transmission when applied to data collected at different centers.

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HLA may be involved in resistance and susceptibility to affective disorders

Payami

Dubay

Valenzuela

1989

Genetic Epidemiology

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The role of HLA in susceptibility to affective disorders was assessed by sib pair linkage analysis and by association studies. Unipolar Disorder (UD) and Bipolar Disorder (BD) were studied separately. Both the sib pair data and the antigen frequency distribution suggested an HLA-linked susceptibility to UD. For BD however, the HLA haplotype sharing distribution in sib pairs was random, but the antigen frequencies suggested at least one positive association and one negative association with HLA. The lack of evidence for linkage to HLA from sib pairs may have been due to the genetic heterogeneity of BD.

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HLA Typing and Affective Disorders: a Study in the Italian Population

Cited by 25 publications

References 6 publications

Human leukocyte antigen alleles in patients with bipolar disorder in the Korean population

Human leukocyte antigen alleles in patients with bipolar disorder in the Korean population

Genetic Studies of Manic-depressive lllness*

HLA may be involved in resistance and susceptibility to affective disorders

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