As the number of deep neural networks (DNNs) to be executed on a mobile system-on-chip (SoC) increases, the mobile SoC suffers from the real-time DNN acceleration within its limited hardware resources and power budget. Although the previous mobile neural processing units (NPUs) take advantages of low-bit computing and exploitation of the sparsity, it is incapable of accelerating high-precision and dense DNNs. This paper proposes energy-efficient signed bit-slice architecture which accelerates both high-precision and dense DNNs by exploiting a large number of zero values of signed bit-slices. Proposed signed bit-slice representation (SBR) changes signed 11112 bitslice to 00002 by borrowing a 1 value from its lower order of bit-slice. As a result, it generates a large number of zero bitslices even in dense DNNs. Moreover, it balances the positive and negative values of 2's complement data, allowing bit-slice based output speculation which pre-computes high order of bit-slices and skips the remaining dense low order of bit-slices. The signed bit-slice architecture compresses and skips the zero input signed bit-slices, and its zero skipping unit also supports the output skipping by masking the speculated inputs as zero. Additionally, the heterogeneous network-on-chip (NoC) benefits exploitation of data reusability and reduction of transmission bandwidth. The paper introduces a specialized instruction set architecture (ISA) and a hierarchical instruction decoder for the control of the signed bit-slice architecture. Finally, the signed bit-slice architecture outperforms the previous bit-slice accelerator, Bitfusion, over ×3.65 higher area-efficiency, ×3.88 higher energyefficiency, and ×5.35 higher throughput.