Ho<sup>3+</sup> doped NaGdF<sub>4</sub> nanoparticles as MRI/optical probes for brain glioma imaging

Deng, Yunlong; Wang, Hao; Gu, Wei; Li, Shuai; Xiao, Ni; Shao, Chen; Xu, Qian; Ye, Ling

doi:10.1039/c3tb21613f

Cited by 58 publications

(38 citation statements)

References 32 publications

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“…After modification with functional groups on the surface of NaGdF 4 nanoparticles, tumor-specific targeted MRI could be realized. 176,177 Also, the NaGdF 4 nanoparticles could be used for both optical bioimaging and MRI applications through doping with fluorescent Ln 3+ ions. 178,179 Amine-functionalized Ln 3+ -doped KGdF 4 nanoparticles were synthesized by Chen and coworkers via one-step solvothermal route by employing polyethylenimine (PEI) as the surfactant and capping ligand.…”

Section: 2mentioning

confidence: 99%

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

et al. 2015

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Section: 2mentioning

confidence: 99%

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

et al. 2015

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“…Nanoparticles based on the NaGdF 4 host lattice are being investigated for a variety of applications such as magnetic resonance imaging (MRI) [1][2][3][4][5][6][7][8][9] , multimodal biological labelling/sensing and imaging, 10-21 photodynamic therapy, 10,[22][23][24] spectral conversion in solar cells, 25,26 and nanothermometers. 27,28 NaGdF 4 and other NaREF 4 nanocrystals (RE = rare earth) are often prepared in oleic acid based solvent mixtures yielding very narrow particle size distributions.…”

Section: Introductionmentioning

confidence: 99%

Size Control of Nearly Monodisperse β-NaGdF₄ Particles Prepared from Small α-NaGdF₄ Nanocrystals

2015

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NaGdF 4 nanocrystals of the hexagonal β-phase can be prepared with very narrow size distribution from small particles of the cubic α-phase of NaGdF 4 , but, until now, this method does not allow to control the final particle size. Here we show that the size of β-NaGdF 4 particles can be varied between 4 nm and more than 60 nm by using small α-phase particles with different sodium content as precursor. Heating of the 3-4 nm α-phase particles dispersed in oleic acid/octadecene solvent leads to Ostwald ripening and the formation of β-NaGdF 4 particles with narrow size distribution in all cases. The size of the β-NaGdF 4 particles increases with increasing sodium deficiency of the α-phase particles indicating that the number of β-phase seeds nucleating in the system depends on the ratio of sodium to gadolinium used in the synthesis of the α-phase material.

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“…Some groups used NaGdF 4 as a host material to obtain magnetic UCNPs. 59,[80][81][82][83][84] For example, Johnson and his co-workers reported a 2.5-8.0 nm NaGdF 4 :Yb,Er nanoparticle for the T 1 -weighted MRI. 80 The Gd 3þ relaxivity values increased from 3.0 to 7.2 mM À1 s À1 with decreased particle size.…”

Section: Ucnps For T 1 -Weighted and T 2 -Weighted Mrimentioning

confidence: 99%

Upconversion nanoparticle as a theranostic agent for tumor imaging and therapy

Fang

Wei

2016

J. Innov. Opt. Health Sci.

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Upconversion nanoparticles (UCNPs) as a promising material are widely studied due to their unique optical properties. The material can be excited by long wavelength light and emit visible wavelength light through multiphoton absorption. This property makes the particles highly attractive candidates for bioimaging and therapy application. This review aims at summarizing the synthesis and modi¯cation of UCNPs, especially the applications of UCNPs as a theranostic agent for tumor imaging and therapy. The biocompatibility and toxicity of UCNPs are also further discussed. Finally, we discuss the challenges and opportunities in the development of UCNP-based nanoplatforms for tumor imaging and therapy.

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Ho³⁺ doped NaGdF₄ nanoparticles as MRI/optical probes for brain glioma imaging

Abstract: CTX-conjugated doped NaGdF4 (CTX-NaGdF4:Ho3+) NPs were prepared by a thermal decomposition method followed by ligand-exchange with TETT silane and CTX conjugation. The potential of these NPs as dual-modal nanoprobes in tiny glioma imaging was demonstrated.

Cited by 58 publications

References 32 publications

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Size Control of Nearly Monodisperse β-NaGdF₄ Particles Prepared from Small α-NaGdF₄ Nanocrystals

Upconversion nanoparticle as a theranostic agent for tumor imaging and therapy

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Ho3+ doped NaGdF4 nanoparticles as MRI/optical probes for brain glioma imaging

Abstract: CTX-conjugated doped NaGdF4 (CTX-NaGdF4:Ho3+) NPs were prepared by a thermal decomposition method followed by ligand-exchange with TETT silane and CTX conjugation. The potential of these NPs as dual-modal nanoprobes in tiny glioma imaging was demonstrated.

Cited by 58 publications

References 32 publications

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Size Control of Nearly Monodisperse β-NaGdF4 Particles Prepared from Small α-NaGdF4 Nanocrystals

Upconversion nanoparticle as a theranostic agent for tumor imaging and therapy

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Product

Resources

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Ho³⁺ doped NaGdF₄ nanoparticles as MRI/optical probes for brain glioma imaging

Size Control of Nearly Monodisperse β-NaGdF₄ Particles Prepared from Small α-NaGdF₄ Nanocrystals