Hodgkin’s Disease and Lactic Acidosis

Thakur, Vashu; Sander, Gary E.; Rab, ST

doi:10.1159/000046003

Cited by 7 publications

(1 citation statement)

References 5 publications

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“…7 Another hypothesis of LA in hematologic malignancies involves mitochondrial dysfunction and overexpression of glycolytic enzymes such as insulin-like growth factor 1 and hexokinase by tumor cells, which leads to high rates of glycolysis and therefore higher glucose levels, which allow the cells to multiply at a rapid rate. 10,11 Neoplastic cells often use anaerobic metabolism even in the presence of oxygen, which results in a large percentage of glucose converted to lactate. 7 Anaerobic glycolysis may also occur when tissue perfusion is diminished by a heavy tumor burden or tumor microemboli.…”

Section: Discussionmentioning

confidence: 99%

A Case Series of Clinically Undiagnosed Hematopoietic Neoplasms Discovered at Autopsy

Podduturi

Guileyardo

Soto

et al. 2015

American Journal of Clinical Pathology

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These cases illustrate the importance of the traditional postmortem examination in not only confirming clinical diagnoses but also identifying previously unknown diagnoses. Hematologic malignancies may present with nonspecific clinical manifestations, and this series of cases also emphasizes the necessity for widening the differential diagnosis in patients with unexplained lactic acidosis and hepatic failure to include hematopoietic malignancies since prompt treatment may be lifesaving.

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Section: Discussionmentioning

confidence: 99%

A Case Series of Clinically Undiagnosed Hematopoietic Neoplasms Discovered at Autopsy

Podduturi

Guileyardo

Soto

et al. 2015

American Journal of Clinical Pathology

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Síndrome general con acidosis láctica de evolución fatal

Aizpuru

Mateo

Palacio

et al. 2004

Revista Clínica Española

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Severe Lactic Acidosis in a 14-Year-Old Female With Metastatic Undifferentiated Carcinoma of Unknown Primary

Cheng¹,

Esparza²,

Knez³

et al. 2004

Journal of Pediatric Hematology/Oncology

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A 14-year-old girl was found to have a large, non-tender breast mass with anemia and thrombocytopenia. The diagnosis of an undifferentiated carcinoma of unknown primary was made after open breast biopsy of the mass with negative immunohistochemical studies for breast malignancies. Further evaluation showed extensive metastatic disease affecting the bone marrow, ribs, liver, and brain with magnetic resonance imaging evidence of carcinomatous meningitis. Despite 2 months of chemotherapy and intensive supportive care, the patient died of severe lactic acidosis and disseminated intravascular coagulation after exaggerated menstrual bleeding. The association of severe lactic acidosis and undifferentiated carcinoma of unknown primary in an adolescent has not been previously described.

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Hodgkin’s Disease and Lactic Acidosis

Cited by 7 publications

References 5 publications

A Case Series of Clinically Undiagnosed Hematopoietic Neoplasms Discovered at Autopsy

A Case Series of Clinically Undiagnosed Hematopoietic Neoplasms Discovered at Autopsy

Síndrome general con acidosis láctica de evolución fatal

Severe Lactic Acidosis in a 14-Year-Old Female With Metastatic Undifferentiated Carcinoma of Unknown Primary

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