Hodgkinoid histiocytosis: an atypical nodal <scp>CD30</scp> and <scp>S100</scp>‐positive histiocytosis with eosinophilia

Tsuyama, Naoko; Noguchi, Masaaki; Asaka, Reimi; Sakata, Seiji; Baba, Satoko; Izumi, Hiroshi; Takeuchi, Kengo

doi:10.1111/his.14718

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Therefore, patients with histiocytosis discovered during the evaluation for eosinophilia should be offered bone marrow examination and testing for recurrently mutated myeloid genes. Hodgkinoid histiocytosis—a very rare entity—presents with eosinophilia and may mimic lymphoma ( 107 ).…”

Section: Review Of the Eosinophil Granulocyte In Health And Diseasementioning

confidence: 99%

The multidisciplinary approach to eosinophilia

et al. 2023

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Eosinophilic granulocytes are normally present in low numbers in the bloodstream. Patients with an increased number of eosinophilic granulocytes in the differential count (eosinophilia) are common and can pose a clinical challenge because conditions with eosinophilia occur in all medical specialties. The diagnostic approach must be guided by a thorough medical history, supported by specific tests to guide individualized treatment. Neoplastic (primary) eosinophilia is identified by one of several unique acquired genetic causes. In contrast, reactive (secondary) eosinophilia is associated with a cytokine stimulus in a specific disease, while idiopathic eosinophilia is a diagnosis by exclusion. Rational treatment is disease-directed in secondary cases and has paved the way for targeted treatment against the driver in primary eosinophilia, whereas idiopathic cases are treated as needed by principles in eosinophilia originating from clonal drivers. The vast majority of patients are diagnosed with secondary eosinophilia and are managed by the relevant specialty—e.g., rheumatology, allergy, dermatology, gastroenterology, pulmonary medicine, hematology, or infectious disease. The overlap in symptoms and the risk of irreversible organ involvement in eosinophilia, irrespective of the cause, warrants that patients without a diagnostic clarification or who do not respond to adequate treatment should be referred to a multidisciplinary function anchored in a hematology department for evaluation. This review presents the pathophysiology, manifestations, differential diagnosis, diagnostic workup, and management of (adult) patients with eosinophilia. The purpose is to place eosinophilia in a clinical context, and therefore justify and inspire the establishment of a multidisciplinary team of experts from diagnostic and clinical specialties at the regional level to support the second opinion. The target patient population requires highly specialized laboratory analysis and therapy and occasionally has severe eosinophil-induced organ dysfunction. An added value of a centralized, clinical function is to serve as a platform for education and research to further improve the management of patients with eosinophilia. Primary and idiopathic eosinophilia are key topics in the review, which also address current research and discusses outstanding issues in the field.

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Section: Review Of the Eosinophil Granulocyte In Health And Diseasementioning

confidence: 99%

The multidisciplinary approach to eosinophilia

et al. 2023

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“…Tsuyama et al more recently reported unique cases of Hodgkinoid histiocytosis with CHL-like morphologic features and CD30 and PD-L1 expression in Hodgkinoid histiocytes. 44 This diagnostic term, “Hodgkinoid”, was created by Tsuyama et al in order to avoid confusion with CHL, which is now defined as GC-derived B-cell neoplasm in the 2022 WHO classification. An international consensus should be achieved for these issues.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic approach for classic Hodgkin lymphoma in small samples with an emphasis on PD-L1 expression and EBV harboring in tumor cells: a brief review from morphology to biology

Takahara

Sakakibara

Tsuyuki

et al. 2023

J Clin Exp Hematopathol

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Classic Hodgkin lymphoma (CHL) was first described in 1832 by Thomas Hodgkin, and is characterized by a small number of Hodgkin and Reed–Sternberg cells in a rich inflammatory background. However, even in this modern era, due to the histological and biological overlap with CHL and other B-cell malignancies, including mediastinal grey zone lymphoma and other lymphomas accompanied by “Hodgkinoid cells”, their discrimination is challenging and sometimes impossible. The complexity and ambiguity of the boundaries of CHL and its related diseases make the definition of CHL unresolved. Our group has studied the significance of PD-L1 expression and infection of Epstein-Barr virus (EBV) in the diagnosis of CHL, emphasizing their pathological role, clinical significance, and high reproducibility even in daily clinical practice. In this review, we summarize the diagnostic strategy of CHL and its histological lookalikes based on neoplastic PD-L1 expression and infection of EBV, and attempt a reappraisal of the definition of CHL.

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Classic Hodgkin lymphoma: An illustrative review of select diagnostic limitations and immunomorphological challenges

El Hussein,

O'Malley

2024

Human Pathology

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Hodgkinoid histiocytosis: an atypical nodal CD30 and S100‐positive histiocytosis with eosinophilia

Cited by 3 publications

References 19 publications

The multidisciplinary approach to eosinophilia

The multidisciplinary approach to eosinophilia

Diagnostic approach for classic Hodgkin lymphoma in small samples with an emphasis on PD-L1 expression and EBV harboring in tumor cells: a brief review from morphology to biology

Classic Hodgkin lymphoma: An illustrative review of select diagnostic limitations and immunomorphological challenges

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