This study investigates the effect of six parameters in the repeatability of drilled holes in laser percussion drilling process by means of statistical techniques. Peak power, pulse width, pulse frequency, number of pulses, gas pressure and focal plane position were considered as independent process parameters. Experiments were designed with the aim of reducing the number of required experiments. The response surface method was used to develop the models for required responses. The significant factors in the process were selected based on the analysis of the variance (ANOVA). The experiments were conducted in mild steel sheet with a thickness of 2 mm. Each experiment was repeated 35 times in order to investigate the repeatability of the process. The equivalent entrance diameter, percentage of standard deviation of entrance diameter (%STD Eq Dia), circularity (ratio of minimum to maximum Feret's diameter) and its standard deviation (STD circularity) were selected as process characteristics. The %STD Eq Dia and STD circularity, respectively, show the repeatability of equivalent diameter and circularity in the process.The results show that the process of drilling smaller hole diameters is more repeatable than drilling larger holes. Pulse width, gas pressure, focal plane position, peak power and number of pulses, respectively, have significant effect on the repeatability of hole diameter and circularity. Pulse frequency has no significant effect on the repeatability of the process.