Hollow chitosan–silica nanospheres as pH-sensitive targeted delivery carriers in breast cancer therapy

Deng, Ziwei; Zhen, Zipeng; Hu, Xiaoxi; Wu, S. L.; Xu, Zushun; Chu, Paul K.

doi:10.1016/j.biomaterials.2011.03.050

Cited by 248 publications

(138 citation statements)

References 48 publications

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“…However, work is still needed on the sensitivity of these drug carriers to the applied stimuli. Some major drawbacks in the field may include the off-tumortargeting caused by non-specific stimuli such as overexpression of target enzymes in non-cancer cells (Spallarossa et al, 2006;Cheng et al, 2009) inaccurate utilization of stimuli such as uncontrolled depth of magnetic field and heating (Sawant et al, 2006;Zhu et al, 2009;Deng et al, 2011) and slow response to applied stimulus (Zhu et al, 2008;Wong et al, 2011).…”

Section: Remained Challengesmentioning

confidence: 99%

Classification of stimuli–responsive polymers as anticancer drug delivery systems

et al. 2014

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Although several anticancer drugs have been introduced as chemotherapeutic agents, the effective treatment of cancer remains a challenge. Major limitations in the application of anticancer drugs include their nonspecificity, wide biodistribution, short half-life, low concentration in tumor tissue and systemic toxicity. Drug delivery to the tumor site has become feasible in recent years, and recent advances in the development of new drug delivery systems for controlled drug release in tumor tissues with reduced side effects show great promise. In this field, the use of biodegradable polymers as drug carriers has attracted the most attention. However, drug release is still difficult to control even when a polymeric drug carrier is used. The design of pharmaceutical polymers that respond to external stimuli (known as stimuli-responsive polymers) such as temperature, pH, electric or magnetic field, enzymes, ultrasound waves, etc. appears to be a successful approach. In these systems, drug release is triggered by different stimuli. The purpose of this review is to summarize different types of polymeric drug carriers and stimuli, in addition to the combination use of stimuli in order to achieve a better controlled drug release, and it discusses their potential strengths and applications. A survey of the recent literature on various stimuli-responsive drug delivery systems is also provided and perspectives on possible future developments in controlled drug release at tumor site have been discussed.

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Section: Remained Challengesmentioning

confidence: 99%

Classification of stimuli–responsive polymers as anticancer drug delivery systems

et al. 2014

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“…Probably, the siRNA was not being fully protected against degradation by nucleases. As reported in others works [37,38], the Chitosan is considered to be a good candidate for a gene delivery carrier with its excellent biocompatibility, biodegradability, low toxicity, and high cationic potential. However, this material shows low transfection efficiency, and it may have been affected by some factors, including chitosan molecular weight, salt form, degree of deacetylation, the pH of the culture medium, and so forth.…”

Section: In Vitro Cellular Uptake Assaysmentioning

confidence: 99%

Biodegradable Polymers Grafted onto Multifunctional Mesoporous Silica Nanoparticles for Gene Delivery

et al. 2018

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Biodegradable polymer possesses significant potential for applications in different fields, since flexibility gives rise to materials with great physical and mechanical property diversity. The poly-caprolactone (PCL) and chitosan derivatives (CS) have the ability to form scaffolds, which adhere to the surface of mesoporous silica nanoparticles (MSNs) and its porous networks. The novel characteristics of the developed PCL/MSNs and CS/MSNs, such as very low in vivo degradation rate, ordered pore network, uniform and tunable size and shape of the particles, high pore volume and surface area, non-toxicity, and biocompatibility, among others, are responsible for its favorable gene delivery device and makes this conjugation a very good biomaterial for this application. In the present study, we investigated the synthesis of silica nanoparticles MCM-41 covalently grafted with PCL and CS and their use as a potential small interfering RNA (siRNA) carrier. The physical-chemical and morphological characterizations, as well as the applicability of functionalized MSNs as platforms for gene delivery, were assessed. Our results confirmed that MSNs that were successfully functionalized with PCL and CS kept their typical morphology and pore arrangement. Furthermore, their surface modification was successfully held. In vitro biocompatibility and cytotoxicity assays suggest the ability of MSNs to support passive uptake and indicated the potential of this material as a gene delivery system for cervical cancer cells (HeLa).

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“…Various physical/chemical stimuli, such as photo, pH, temperature and enzymes, have been used as actuators for uncapping the gatekeepers and releasing entrapped guest molecules (Xue et al, 2011). As the acidic tumor microenvironment is most common in solid tumors, the pH targeting approach is regarded as a more general strategy than many other targeting approaches (Meng et al, 2010;Deng et al, 2011;Wen et al, 2012;Xi et al, 2012). Methotrexate is an anticancer drug which is widely used for the treatment of breast cancer and epidermoid cancer of the head and lung cancer (Kang et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and pH-controllable methotrexate release from biocompatible polymer/silica nanocomposite for anticancer drug delivery

Rasouli¹,

Davaran²,

Rasouli³

et al. 2013

Drug Delivery

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The objective of this study was to develop pH-responsive silica nanoparticles by imidazolebased ionic liquid for controlled release of methotrexate. In this article, we synthesized pHresponsive cationic silica nanoparticles by graft copolymerization of vinyl functionalized silica nanoparticles and methacrylic acid (MAA) monomer. Imidazole-based ionic liquid (Im-IL) was verified by 1 HNMR and Fourier-transform infrared (FTIR) spectroscopy. The synthesized functionalized silica particles were characterized and confirmed by various technologies including the scanning electron microscopy (SEM), the infrared spectroscopy (IR) and the thermogravimetric analysis (TGA). SEM results reveal the uniformity in size/shape of silica particles. This nanosystem is modified for targeted delivery of an anticancer agent methotrexate. The nanocomposite-MTX complex was formed at physiological pH (7.4) due to the electrostatic interactions between anionic carboxylic group of MTX molecules and cationic rings in carrier, while, the release of which can be achieved through the cleavage of the nanocomposite-MTX complex by protonation of carboxyl groups in the MTX segment that are sensitive to variations in external pH at weak acidic conditions. FT-IR spectroscopy showed the presence of light interactions between the silicate silanols and the drug. MCF7 cells were incubated with the MTX-free nanocomposite and MTX-loaded nanocomposite at various concentrations for 24, 48 and 72 h, and the data showed that the nanocomposites themselves did not affect the growth of MCF7 cells. Antitumor activity of the MTX-loaded nanocomposites against the cells was kept over the whole experiment process. The results showed that the MTX could be released from the fibers without losing cytotoxicity.

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Hollow chitosan–silica nanospheres as pH-sensitive targeted delivery carriers in breast cancer therapy

Cited by 248 publications

References 48 publications

Classification of stimuli–responsive polymers as anticancer drug delivery systems

Classification of stimuli–responsive polymers as anticancer drug delivery systems

Biodegradable Polymers Grafted onto Multifunctional Mesoporous Silica Nanoparticles for Gene Delivery

Synthesis, characterization and pH-controllable methotrexate release from biocompatible polymer/silica nanocomposite for anticancer drug delivery

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