Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine

Abstract

Chemical construction of molecularly organic-inorganic hybrid hollow mesoporous organosilica nanoparticles (HMONs) with silsesquioxane framework is expected to substantially improve their therapeutic performance and enhance the biological effects beneficial for biomedicine. In this work, we report on a simple, controllable, and versatile chemical homology principle to synthesize multiple-hybridized HMONs with varied functional organic groups homogeneously incorporated into the framework (up to quintuple hybridizations). As a paradigm, the hybridization of physiologically active thioether groups with triple distinctive disulfide bonds can endow HMONs with unique intrinsic reducing/acidic- and external high intensity focused ultrasound (HIFU)-responsive drug-releasing performances, improved biological effects (e.g., lowered hemolytic effect and improved histocompatibility), and enhanced ultrasonography behavior. The doxorubicin-loaded HMONs with concurrent thioether and phenylene hybridization exhibit drastically enhanced therapeutic efficiency against cancer growth and metastasis, as demonstrated both in vitro and in vivo.

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

“…However, pure PB nanoparticles cannot deliver drug for cancer chemotherapy because of their small micropores and limited loading capacity. Periodic mesoporous organosilicas (PMOs) synthesized via surfactant‐directed sol–gel process has been used for drug delivery because of their uniform and large mesopore size, high surface area, organic groups incorporated frameworks, and excellent biodegradation and biocompatibility 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43. Based on the unique features, we presumed that an imaging‐guided combination therapy strategy can be developed by intergating the advantages of PMO and PB.…”

Mesoporous carbon biomaterials

“…Biocompatible inorganic mesoporous materials have attracted great attention in biomedicine over the past decades [24][25][26][27][28]. The well-defined mesoporous structures with large surface area, high pore volume, and tunable pore sizes provide large reservoirs for guest molecules and show sustained drug-release profiles [29][30][31].…”

Colloidal Mesoporous Silica Nanoparticles

“…159 Shi et al reported the preparation of hollow colloidal MSNs (or organosiloxane) by using more than two kinds of bridged silsesquioxanes simultaneously. 162 Recently, well-dispersed colloidal mesoporous benzene-bridged organosiloxane nanoparticles were prepared by Yang et al through biphasic synthesis. 168 As shown above, the compositional variation has been expanded and further developments will be expected.…”