Hollow microspheres as a drug carrier: An overview of fabrication and<i>in vivo</i>characterization techniques

Kurrey, Avinash; Suresh, Preeti K.; Singh, Manju Rawat

doi:10.4103/2229-5186.129327

Cited by 6 publications

(1 citation statement)

References 45 publications

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“…Based on the results of the mechanical properties, all the gels appeared to offer suitable mechanical properties for mucosal application, being in accordance with the results obtained by other researchers. 28,29 As can be seen from Table 3, the presence of NYS affected the mechanical properties of the formulations.…”

Section: Mechanical Properties Of Gel Formulationsmentioning

confidence: 94%

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Rençber¹,

Cheaburu-Yılmaz²,

Köse³

et al. 2019

Cellulose Chem. Technol.

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Interpolymeric complexes (IPCs) have the advantage of combined properties of their constituent polymers. They are easy to prepare under mild conditions and do not require high processing costs. The interpolymeric complexes of alginate, chitosan and Nystatin, as antifungal drug systems, represent an alternative for mucosal illness treatment. The composition of the two polymers is a key parameter in obtaining the desired properties for pharmaceutical formulations. IPCs of sodium alginate (SA) and chitosan (CS) were prepared via solution mixing method with various compositions, followed by coacervation in 2-propanol. The outcome obtained from rheological measurements was that the complex SA/CS 60/40 (v/v %) fulfilled the requirements of a semi-solid formulation, e.g. pseudoplasticity. Nystatin showed very good compatibility with the polymeric system. The drug loaded gels showed better rheological, textural and mechanical properties (e.g. pseudoelasticity, spreadability, surface adhesion etc.). The final gel formulations showed no cytotoxic effects in the cell culture assay.

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Section: Mechanical Properties Of Gel Formulationsmentioning

confidence: 94%

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Rençber¹,

Cheaburu-Yılmaz²,

Köse³

et al. 2019

Cellulose Chem. Technol.

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Controlling drug delivery from polymer microspheres by exploiting the complex interrelationship of excipient and drug crystallization

Shpigel

Taguri

Lewitus

2018

J of Applied Polymer Sci

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Semicrystalline polymers are often used as macromolecular excipients in active pharmaceutical ingredient (API)‐delivery systems. In such systems, the morphological structure and crystalline characteristics of the excipient have a direct impact upon the drug‐delivery rate. In this study, polycaprolactone (PCL)‐based microspheres prepared via melt‐printing were loaded with 10, 30, and 50% ibuprofen (IBU). In vitro release studies showed that, for a constant amount of IBU, the API was released fastest from the 30%‐loaded microspheres, followed by the 50%‐ and 10%‐loaded microspheres. The discrepancy in these release rates was investigated using scanning electron microscopy, differential scanning calorimetry, X‐ray diffraction, and thermodynamic analyses, revealing the complex morphological and crystalline interrelationships of PCL and IBU. Although it is generally accepted that the degree of crystallinity of the excipient is the main factor controlling the release of the API, we found that the crystallite size of the small‐molecule API is of primary importance. Moreover, these factors, which are controllable via the parameters used in melt‐based preparation, can be exploited to tune drug‐release rates. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47227.

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Fabrication of hydrogel mini-capsules as carrier systems

Roberti,

Petrucci,

Bianciardi

et al. 2023

Open Res Europe

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Conventional drug administration often results in systemic action, thus needing high dosages and leading to potentially pronounced side effects. Targeted delivery, employing carriers like nanoparticles, aims to release drugs at a target site, but only a small fraction of nanoparticles actually reaches it. Microrobots have been proposed to overcome this issue since they can be guided to hard-to-reach sites and locally deliver payloads. To enhance their functionality, we propose microrobots made as deformable capsules with hydrogel shells and aqueous cores, having the potential added advantages of biocompatibility, permeability, and stimulus-responsiveness. In this study, we present a cost-effective method for fabricating core-shell structures without the use of organic solvents or surfactants. The process begins with the dripping of a mixture of hydrogels, agarose and alginate, into a solution to gelate the drops into beads. After they are loaded with calcium ions at different concentrations, they are immersed in an alginate solution to form the shell. Finally, the beads are heated to let the agarose melt and diffuse out, leaving a liquid core. By varying the concentration of calcium ions, we obtain shells of different thickness. To estimate it, we have developed a method using the colour intensity from microscope images. This allowed us to observe that lowering the calcium ions concentration below a threshold does not lead to the formation of continuous shells. For higher concentrations, although the core may remain partially gelled, continuous shells successfully form. Therefore, our fabrication process could find applications in drug delivery, encapsulation systems, and microrobotics.

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Hollow microspheres as a drug carrier: An overview of fabrication andin vivocharacterization techniques

Cited by 6 publications

References 45 publications

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Controlling drug delivery from polymer microspheres by exploiting the complex interrelationship of excipient and drug crystallization

Fabrication of hydrogel mini-capsules as carrier systems

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