Hollow microspheres based on – Folic acid modified – Hydroxypropyl Cellulose and synthetic multi-responsive bio-copolymer for targeted cancer therapy: Controlled release of daunorubicin, in vitro and in vivo studies

PLGA nanofibers improves the antitumoral effect of daunorubicin

“…This behavior could be a consequence of the DNR hydrogen interaction with the PLGA matrix, as observed and discussed in the DNR-PLGA nanofiber TG, DSC and XRD. This would indicate that DNR may be entrapped physically in the polymer matrix, as observed elsewhere [46]. From a pharmaceutical perspective, a release in the form of an initial burst is required to promote a local antitumor effect in which the initial dose kills a majority of cancerous cells, whereas the subsequent controlled release prevents tumor cell growth and proliferation [47].…”

“…From a pharmaceutical perspective, a release in the form of an initial burst is required to promote a local antitumor effect in which the initial dose kills a majority of cancerous cells, whereas the subsequent controlled release prevents tumor cell growth and proliferation [47]. Moreover, due to the fact that extracellular compartments of solid tumors are more acidic than normal tissues, DNR release is favored by high rate of polymer hydrolysis [46]. This novel system appears to be a promising clinical strategy in which PLGA-DNR nanofibers can be used as a local device for targeted DNR delivery to a tumor, as required.…”

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

“…Few other characteristics of HPMC such as sol-gel transformation properties have also been studied to improve the solubility characteristics and bioavailability of poorly water soluble drugs [22]. Further, development of HPMC-based new matrices for controlled release of drugs has also been studied by various researchers [23,24]. Deng et al [25] recently reported the development of new collagen-HPMC blend material which shows improved physical and chemical properties [13].…”

Novel multi-responsive polymer materials: When ionic liquids step in

“…In many cases, a wide rang of multiple stimuli-responsive materials has been designed for drug delivery systems, where the basic structures and residual substances are mostly required for biocompatibility or biodegradability [2,5,[12][13][14]. Many other applications such as the detection, optical data storage, and sensing applications require the electrochemically active material to a certain extent while maintaining their original shape.…”

“…Their potential applications in various fields including drug delivery [2,5,12,13], imaging [14], sensors [15,16], functional coats [17], catalysis [18] have been inspiring researchers to discover novel MRPMs processing routes in two main directions: exploring novel responsive polymers and investigating the effects of various interactions at the molecular level under different circumstances [19][20][21][22][23].…”