Holographic acoustic tweezers

We determine crystal-like materials that can be fabricated by using a standing acoustic wave to arrange small particles in a non-viscous liquid resin, which is cured afterwards to keep the particles in the desired locations. For identical spherical particles with the same physical properties and small compared to the wavelength, the locations where the particles are trapped correspond to the minima of an acoustic radiation potential which describes the net forces that a particle is subject to. We show that the global minima of spatially periodic acoustic radiation potentials can be predicted by the eigenspace of a small real symmetric matrix corresponding to its smallest eigenvalue. We relate symmetries of this eigenspace to particle arrangements composed of points, lines or planes. Since waves are used to generate the particle arrangements, the arrangement’s periodicity is limited to certain Bravais lattice classes that we enumerate in two and three dimensions.

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“…Hence exp[i[K T ; −K T ]x] [v; ±v] is also a λ-eigenvector of Q(0). By (10) this implies that ψ(x; u) = λ.…”

Section: 4mentioning

confidence: 93%

Periodic particle arrangements using standing acoustic waves

Vasquez

Mauck

2019

Proc. R. Soc. A.

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“…The analogous dipole-order acoustic radiation force experienced by a small particle in a harmonic sound field arXiv:1910.03670v2 [cond-mat.soft] 11 Nov 2019 may be expressed in terms of the pressure, p(r, t), as [14] F(r) = 1 2 α a p∇p * + β a k −2 (∇p · ∇)∇p * , (4) where the coefficients α a and β a play the role of dipole and quadrupole polarizabilities, respectively. Expressing F(r) in terms of multipole polarizabilities clarifies the analogy with photokinetics.…”

Section: B Sound: Acoustic Radiation Forcesmentioning

confidence: 99%

“…Structured sound waves exert forces and torques that can be harnessed to transport, sort and organize insonated objects [1][2][3][4]. Applications include non-contact processing of sensitive [5,6] and hazardous [7] materials, flow focusing for materials analysis and medical diagnostics [8], and automated remote manipulation for research [9].…”

Section: Introductionmentioning

confidence: 99%

Acoustokinetics: Crafting force landscapes from sound waves

Abdelaziz

Grier

2020

Phys. Rev. Research

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Factoring the pressure field of a harmonic sound wave into its amplitude and phase profiles provides the foundation for an analytical framework for studying acoustic forces that not only provides novel insights into the forces exerted by specified sound waves, but also addresses the inverse problem of designing sound waves to implement desired force landscapes. We illustrate the benefits of this acoustokinetic framework through case studies of purely nonconservative force fields, standing waves, pseudo-standing waves, and tractor beams.

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“…However, few methods exist to dynamically configure the location of cells in 3-D space. In contrast, ARF in the form of engineered standing and traveling waves has been used to create complex 2-D and 3-D arrangements [23][24][25] .…”

Section: Heterologous Expression Of Gvs Enables Selective Acoustic Mamentioning

confidence: 99%

Genetically encoded nanostructures enable acoustic manipulation of engineered cells

Baresch

Cook

et al. 2019

Preprint

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The ability to mechanically manipulate and control the spatial arrangement of biological materials is a critical capability in biomedicine and synthetic biology. Ultrasound has the ability to manipulate objects with high spatial and temporal precision via acoustic radiation force, but has not been used to directly control biomolecules or genetically defined cells. Here, we show that gas vesicles (GVs), a unique class of genetically encoded gas-filled protein nanostructures, can be directly manipulated and patterned by ultrasound and enable acoustic control of genetically engineered GV-expressing cells. Due to their differential density and compressibility relative to water, GVs experience sufficient acoustic radiation force to allow these biomolecules to be moved with acoustic standing waves, as demonstrated within microfluidic devices. Engineered variants of GVs differing in their mechanical properties enable multiplexed actuation and act as sensors of acoustic pressure. Furthermore, when expressed inside genetically engineered bacterial cells, GVs enable these cells to be selectively manipulated with sound waves, allowing patterning, focal trapping and translation with acoustic fields. This work establishes the first genetically encoded nanomaterial compatible with acoustic manipulation, enabling molecular and cellular control in a broad range of contexts.

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Holographic acoustic tweezers

Cited by 403 publications

References 53 publications

Periodic particle arrangements using standing acoustic waves

Periodic particle arrangements using standing acoustic waves

Acoustokinetics: Crafting force landscapes from sound waves

Genetically encoded nanostructures enable acoustic manipulation of engineered cells

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