1991
DOI: 10.1016/s0040-4020(01)86479-6
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Holothurinosides: New antitumour non sulphated triterpenoid glycosides from the sea cucumber holothuria forskalii.

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Cited by 70 publications
(55 citation statements)
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“…Finally, reversed-phase HPLC on Zobax SBC-18 afforded compounds 1 and 2. DEPT and that the carbohydrate moieties of these new glycosides were identical to each other and coincident with that of the earlier known holothurinoside A [5]. The relative configurations at all stereogenic C-atoms of the oligosaccharide chain were established by NOESY experiments, as shown in the Figure.…”
supporting
confidence: 61%
“…Finally, reversed-phase HPLC on Zobax SBC-18 afforded compounds 1 and 2. DEPT and that the carbohydrate moieties of these new glycosides were identical to each other and coincident with that of the earlier known holothurinoside A [5]. The relative configurations at all stereogenic C-atoms of the oligosaccharide chain were established by NOESY experiments, as shown in the Figure.…”
supporting
confidence: 61%
“…This saponin corresponds to holothurinoside G described in Van Dyck et al (Van Dyck et al, 2009). When the animal was stressed, it secreted three other known saponins (ions detected at m/z 1125, 1141 and 1433, corresponding to holothurinoside C, desholothurin A and holothurinoside F, respectively) (Rodrigez et al, 1991;Van Dyck et al, 2009) and two new congeners detected at m/z 1301 and 1317 (Fig.6B). MALDI-MS/MS analyses were performed to confirm that the detected ions corresponded to the known saponins and to propose a molecular structure for the two new ones (Fig.7).…”
Section: Identification Of Saponins Released In Seawatermentioning
confidence: 72%
“…In H. forskali, 26 different saponins have been described in the Cuvierian tubules and 12 have been described in the body wall (Rodrigez et al, 1991;Van Dyck et al, 2009). To understand the biological function of this molecular set, we have undertaken an integrated study about their precise localization in the body wall, their respective concentrations in and around the animals, and their effects on potential predatory fish.…”
Section: Discussionmentioning
confidence: 99%
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“…En estas especies se presentan nuevas saponinas y sapogeninas, glucósidos triterpénicos con grupos sulfatos, todos extraídos a partir de los órganos de Cuvier de estos organismos. Estos compuestos presentan propiedades biológicas como antifúngicos, antitumorales, anti-protozoarios, biocidas en general, y un gran espectro de actividad antiviral no solo a nivel de bioensayo sino ya a nivel de formas farmacéuticas tales como: inyectables, supositorios, y tabletas, específicamente inhibidor de reverso transcriptasa VIH (Silchenko et al,2002;Maier et al, 2001;Miyamoto et al, 1990) con perspectivas reales en el tratamiento contra esta pandemia y también frente al tratamiento de HSV (Maier et al, 2001;Avilov et al, 2000aAvilov et al, , 1998bAvilov et al, , 1997cCollin, 1999;Miyamoto et al, 1992aMiyamoto et al, , 1990bAvilov et al, 1998;Rodriguez et al, 1991;Beutler et al, 1993).…”
Section: Cucumaria Frondosaunclassified