Homeopathic remedy made from Toxoplasma gondii reduces the number of bradyzoites in mice infected by the protozoan

Braga-Silva, Caroline Felicio; Drozino, Ricardo Nascimento; Moreira, Neide Martins; Góis, Marcelo Biondaro; Sant’Ana, Débora de Mello Gonçales; Falavigna-Guilherme, Ana Lúcia; Araújo, Silvana Márques de

doi:10.1016/j.eujim.2015.05.002

Cited by 6 publications

(1 citation statement)

References 29 publications

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“…The feces were treated with liquid nitrogen and stored at − 80 °C. The mice were sacrificed at 42 dpi, the brains were homogenized, and the cysts were counted three times as described previously 58 .…”

Section: Methodsmentioning

confidence: 99%

Study on the effect of koumiss on the intestinal microbiota of mice infected with Toxoplasma gondii

Yan

Han

Jin

et al. 2022

Sci Rep

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Toxoplasma gondii is a worldwide food-borne parasite that can infect almost all warm-blooded animals, including humans. To date, there are no effective drugs to prevent or eradicate T. gondii infection. Recent studies have shown that probiotics could influence the relationship between the microbiota and parasites in the host. Koumiss has been used to treat many diseases based on its probiotic diversity. Therefore, we explored the effect of koumiss on T. gondii infection via its effect on the host intestinal microbiota. BALB/c mice were infected with T. gondii and treated with PBS, koumiss and mares’ milk. Brain cysts were counted, and long-term changes in the microbiota and the effect of koumiss on gut microbiota were investigated with high-throughput sequencing technology. The results suggested that koumiss treatment significantly decreased the cyst counts in the brain (P < 0.05). Moreover, T. gondii infection changed the microbiota composition, and koumiss treatment increased the relative abundance of Lachnospiraceae and Akkermansia muciniphila, which were associated with preventing T. gondii infection. Moreover, koumiss could inhibit or ameliorate T. gondii infection by increasing the abundance of certain bacteria that control unique metabolic pathways. The study not only established a close interaction among the host, intracellular pathogens and intestinal microbiota but also provided a novel focus for drug development to prevent and eradicate T. gondii infection.

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Section: Methodsmentioning

confidence: 99%