Homeopathic Treatment of Insomnia and Symptom Clusters Related to Cerebral Chemotoxicity in Oncology

Bagot, Jean-Lionel; Marechaud, Natalia; Deana, Nicolas; Wendling, Julie

doi:10.1055/s-0038-1666807

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…A potential common mechanism underlying pain, disturbed sleep, and fatigue may be a set of “sickness behaviors” triggered by inflammation and include cognitive dysfunction and affective symptoms that share a common cytokine-based neuroimmune mechanism [ 22 , 23 ]. A study stated that the symptom cluster of insomnia patients with cancer can consist of insomnia, fatigue, anxiety, pain, depressed mood, and cognitive disorders, and the common biological mechanism may be related to brain inflammation by proinflammatory cytokine production, and proposed a homeopathic protocol for Belladonna 15c, Phosphorus 15c, Cerebral cortex 4c, and Nerves 4c to prevent chemotherapy-induced brain symptoms [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…The symptoms in the symptom cluster are characterized by compactness, simultaneity, and stability [ 7 ] and may have a common biological mechanism [ 8 ]. Research on cancer symptom cluster has made progress in symptom cluster identification and subgroup analysis [ 9 , 10 ], stability analysis of symptom cluster [ 11 ], discussion on biological mechanism of symptom cluster, and clinical intervention of symptom cluster [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Symptom burden survey and symptom clusters in patients with cervical cancer: a cross-sectional survey

Zhou

Wang

Xie

et al. 2023

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Purpose The purpose of this study is to determine the incidence and severity of symptoms of patients with cervical cancer within 6 months after radiotherapy and chemotherapy, form a symptom burden report, evaluate the distribution characteristics of symptoms, identify symptom clusters, and provide a basis for clinical doctors and nurses to improve the symptom management of patients with cervical cancer after radiotherapy and chemotherapy. Methods The patients with cervical cancer within 6 months after radiotherapy and chemotherapy were recruited to investigate their symptom burden. Exploratory factor analysis was used to identify symptom clusters. Results A total of 250 patients participated in the study. The study found that the most common symptom among the 40 symptoms was fatigue, and the most serious symptom was nocturia. Based on the occurrence rate and severity of symptoms, nine symptom clusters were identified, including psycho–emotion-related symptom cluster, pain–disturbed sleep-related symptom cluster, menopausal symptom cluster, tinnitus–dizziness-related symptom cluster, urinary-related symptom cluster, dry mouth–bitter taste-related symptom cluster, intestinal-related symptom cluster, memory loss–numbness-related symptom cluster, and emaciation-related symptom cluster. The three most serious symptom clusters are pain–disturbed sleep-related symptom cluster, urinary-related symptom cluster, and memory loss–numbness-related symptom cluster. Conclusion The symptoms of patients with cervical cancer within 6 months after radiotherapy and chemotherapy are complex, and nine symptom clusters can be identified according to the incidence and severity of symptoms. We can find the potential biological mechanism of each symptom cluster through the discussion of previous mechanism research and clinical research. The number of symptom clusters and the number of symptoms within the symptom cluster are closely related to the symptom evaluation scale selected for the study. Therefore, the symptom cluster study urgently needs a targeted symptom evaluation scale that can comprehensively reflect the patient’s condition.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Symptom burden survey and symptom clusters in patients with cervical cancer: a cross-sectional survey

Zhou

Wang

Xie

et al. 2023

Support Care Cancer

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“…Therefore, it is important to protect the central nervous system from the oxidative stress caused by the release in the brain of pro-inflammatory cytokines such as the IL-1, the IL-6 or TNF-alpha. Homeopathic antiinflammatory drugs for the brain, such as belladonna, aconitum napellus or phosphorus, will be used for this [2].…”

Section: How To Use It In Practice?mentioning

confidence: 99%

Indications of Okoubaka aubrevillei in oncological supportive care

Bagot¹

2020

Allgemeine Homöopathische Zeitung

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ZusammenfassungDer Ende des letzten Jahrhunderts entdeckte Okoubaka-aubrevillei-Stamm ist in homöopathischen Kreisen immer noch unzureichend bekannt. Ursprünglich bei der Behandlung von Lebensmittelvergiftungen angezeigt, ist seine Verwendung in der begleitenden onkologischen Behandlung neu. Die Synthese verschiedener existierender Prüfungen ermöglichte es uns, eine Materia medica für Okoubaka zusammenzustellen, in der es ähnliche Symptome zu Nux vomica und Arsenicum album zeigt. Die Ätiologie „nach einer Vergiftung“ und die Nähe zum Verdauungssystem haben uns in den letzten 10 Jahren veranlasst, es zur Verhinderung von chemotherapeutischen Nebenwirkungen zu verwenden. Wir haben es kurz vor und während jeder Chemotherapie bei ca. 1000 Patienten eingesetzt. Unsere klinische Erfahrung bestätigt die onkologische Indikation zur Vorbeugung der gastroenterologischen Toxizität einer Chemotherapie, wie Übelkeit oder Durchfall. Die Veröffentlichung klinischer Fälle oder sogar klinischer Studien sollte es ermöglichen, die Verwendung in der Onkologie zu spezifizieren.

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The characteristics and related factors of insomnia among postoperative patients with gastric cancer: a cross-sectional survey

Zhu

et al. 2021

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Purpose This study aims to explore the characteristics and related factors of insomnia of patients after operation for gastric cancer. Methods A cross-sectional survey was carried out and finally 115 patients with insomnia after operation for gastric cancer were included. The general information, gastric cancer-related information, sleep quality, and other symptoms were investigated. Results ① The Pittsburgh sleep quality index score of most insomnia patients after gastric cancer surgery was 11-15 points, and the sleep quality rating was “poor”. ② The sleep quality of patients with insomnia after surgery for gastric cancer is related to the number of chemotherapy cycles, fatigue, and depression. ③ The probability of reduced sleep quality with the number of chemotherapy cycles >6 is 3.640 times that of ≤6. The probability of reduced sleep quality during moderate to severe fatigue was 4.390 times that of patients with no or mild fatigue. Conclusion Attention to related factors may be associated with improvement of sleep quality in patients with gastric cancer after surgery.

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Homeopathic Treatment of Insomnia and Symptom Clusters Related to Cerebral Chemotoxicity in Oncology

Cited by 6 publications

References 40 publications

Symptom burden survey and symptom clusters in patients with cervical cancer: a cross-sectional survey

Symptom burden survey and symptom clusters in patients with cervical cancer: a cross-sectional survey

Indications of Okoubaka aubrevillei in oncological supportive care

The characteristics and related factors of insomnia among postoperative patients with gastric cancer: a cross-sectional survey

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