Homeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c mice

Siqueira, Camila Monteiro; Motta, Priscila Dias; Cardoso, Thayná Neves; Coelho, Cidéli de Paula; Popi, Ana Flávia; Couceiro, J. N. S. S.; Bonamin, Leoni Villano; Holandino, Carla

doi:10.1016/j.homp.2016.04.002

Cited by 11 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The interaction between macrophages and B1 cells in chronic inflammation is already described (RUSSO; MARIANO, 2010), as well as the modulation of this interaction by thymulin 5CH (BONAMIN et al, 2013). Besides the modulation of protozoan and bacterial infections, thymulin 5CH also increased B2 lymphocyte population in the spleen of mice inoculated with soluble viral antigens (SIQUEIRA et al, 2016) and improved the quality of life of broiler chickens with viral arthritis (SATO et al, 2012).…”

Section: Discussionmentioning

confidence: 72%

“…The first studies on the use of very low doses of thymulin as immunomodulator factor in the literature date from the 1980s (BASTIDE et al, 1985;1987;DAURAT et al, 1988). More recently, the immunomodulatory effects of high dilutions of thymulin were described in viral, bacterial and protozoan experimental infections in vivo (SATO et al, 2012;BONAMIN et al, 2013;RODRIGUES de SANTANA et al, 2014;SIQUEIRA et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Thymulin purified peptide might be obtained from calf thymus acid lysate and acts on T, B and natural killer (NK) cells modulating their proliferation, differentiation and activity (BACH 1979;REGGIANI et al, 2009;. Previous studies showed that high-diluted thymulin prepared according to the homeopathic pharmacopeia (ANVISA 2011) exerts immune-modulatory effects in different experimental situations, mainly in low potencies, whose concentration is near to the physiological level (BASTIDE et al, 1985;1987;DAURAT et al, 1988;BONAMIN et al, 2013;RODRIGUES DE SANTANA et al, 2014;BONAMIN, BELLAVITE, 2015;POITEVIN, 2015;SIQUEIRA et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High-diluted thymulin on Ehrlich tumor growth in mice and the importance of tumor microenvironment

Amaral¹,

Cardoso²,

Carvalho³

et al. 2021

Int J High Dilution Res

Self Cite

View full text Add to dashboard Cite

Introduction: The aim of the present study was to describe different biological aspects of Ehrlich tumor in mice, such as body weight evolution, tumor growth rate, histological organization and systemic immune response after treatment with high-diluted thymulin (10-9 M, named 5CH). Methods: Tumor assessment was focused on macro- and microscopic aspects; parameters included occurrence of necrosis, embolism and tumor development, in addition to quantitative analysis of apoptosis (caspase-3), cell proliferation (Ki-67) and angiogenesis (vascular endothelial growth factor - VEGF) by means of specific immunohistochemistry markers. Spleen cell populations were evaluated by flow cytometry analysis. Results: Mice treated with thymulin 5CH exhibited changes in the tumor microenvironment, such as reduced micro-embolism incidence and cytokeratin expression, with increased caspase-3 expression in the tumor cells. These findings indicate some apoptotic activity by the tumor cells induced by the treatment, even though no reduction of the macroscopic tumor mass occurred. No changes in the systemic immune response were detected, as the balance among spleen cell populations remained unchanged. Conclusions: The results indicate that treatment of mice bearing Ehrlich tumor with thymulin 5CH induces some specific changes in the tumor environment. However, it did not influence systemic immunity parameters. Adjuvant use of thymulin 5CH in oncological clinical practice is still a matter of discussion.

show abstract

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High-diluted thymulin on Ehrlich tumor growth in mice and the importance of tumor microenvironment

Amaral¹,

Cardoso²,

Carvalho³

et al. 2021

Int J High Dilution Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…The immunomodulatory function of Homoeopathic medicines is also proven by the decrease inCD11b and TER-119 markers [29] . Flow cytometry and morphometry revealed significant changes in T and B cell balance after influenza antigen challenge in BALB/c mice, showing that homeopathic treatment induces subtle changes in acquired immune anti-viral response regulation [30] . Influenzinum RC induced morphological alterations in Madin-Darby canine kidney (MDCK) cells indicating a significant increase in this cytokine [31] .…”

Section: Homoeopathic Immunological Evidence In Inflammatory Disordersmentioning

confidence: 96%

Homoeopathy and immunomodulation: A narrative review article

Nahar¹

2021

Int. J. Homoeopathic Sci.

View full text Add to dashboard Cite

show abstract

“…Dentre os vários trabalhos, encontram-se alguns clássicos como os publicados por Belon e colaboradores 3 , que evidenciam que a relação "chavefechadura" não pode ser comprovada nos experimentos homeopáticos, em contraposição aos modelos alopáticos tradicionais. Entretanto, utilizando células do sistema imune, como macrófagos, se verifica que estas soluções diluídas e dinamizadas são capazes de estimular a liberação de citocinas 4 , apresentando uma atividade imunomoduladora facilmente comprovada também em sistemas complexos[5][6][7] . Outros efeitos sutis têm sido registrados, como a ativação de reações apoptóticas por medicamentos homeopáticos, as quais justificam a atividade antitumoral destas substâncias8 .…”

unclassified

Medicamentos homeopáticos e o paradigma da evidência científica

Holandino

2018

J Manag Prim Health Care

Self Cite

View full text Add to dashboard Cite

ResumoMedicamentos homeopáticos são toda forma farmacêutica de dispensação ministrada segundo o princípio da semelhança e/ou identidade, com finalidade curativa e/ou preventiva. O princípio hipocrático da semelhança foi experimentado por Hahnemann, que assim o definiu em 1796: "Toda substância que administrada em doses ponderais, até mesmo tóxica para o homem de boa saúde, desencadeia distúrbios precisos, torna-se, depois de diluída e agitada, capaz de induzir o desaparecimento desses mesmos distúrbios em indivíduos doentes". Este é considerado até os dias de hoje o grande paradigma homeopático e, no presente estudo, o discutimos com base na literatura acadêmico-científica. Os trabalhos realizados com diferentes modelos evidenciam que as altas diluições homeopáticas são soluções que possuem atividade farmacológica e que, portanto, não podem ser consideradas placebos. O cenário atual é bastante promissor, uma vez que a qualidade metodológica, assim como a compreensão acerca dos alvos celulares e moleculares disparados pelo estímulo homeopático, têm conferido status científico a esta terapêutica baseada em evidências. O avanço na compreensão dos mecanismos de ação depende de alguns desafios que precisam ser superados, tais como: aumento do número de pesquisadores interessados na compreensão dos sistemas dinamizados; ampliação dos modelos experimentais capazes de registrar alterações físicas, químicas e biológicas disparadas pelos medicamentos homeopáticos; e reprodutibilidade dos resultados experimentais. Estes e outros aspectos devem ser estimulados no ambiente acadêmico e profissional, a fim de romper as barreiras e os paradigmas que se contrapõem ao avanço desta AbstractHomeopathic medicines are every pharmaceutical form of dispensing delivered according to the

show abstract

Homeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c mice

Abstract: The results show that both homeopathic treatments induced subtle changes in acquired immune anti-viral response regulation. A deeper understanding of the mechanism could elucidate their possible use in influenza epidemiological situations.

Cited by 11 publications

References 18 publications

High-diluted thymulin on Ehrlich tumor growth in mice and the importance of tumor microenvironment

High-diluted thymulin on Ehrlich tumor growth in mice and the importance of tumor microenvironment

Homoeopathy and immunomodulation: A narrative review article

Medicamentos homeopáticos e o paradigma da evidência científica

Contact Info

Product

Resources

About