Homeostatic regulation and Pavlovian conditioning in tolerance to amphetamine-induced anorexia.

Cx, Poulos; Wilkinson, David A.; Cappell, Howard

doi:10.1037/h0077838

Cited by 97 publications

(72 citation statements)

References 17 publications

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“…Although Pavlovian models of drug tolerance (Kesner & Baker, 1981;Poulos & Hinson, 1984;Poulos et al, 1981;Siegel, 1979Siegel, , 1983) specifically predict the elicitation of compensatory CRs by drug-associated cues, the observation of such responses would not provide unequivocal support for the model, even if such observations were consistently reported. This is clear particularly for biphasic responses such as locomotor activity.…”

Section: Discussionmentioning

confidence: 77%

Environmental control of morphine tolerance in the hamster

Schnur

Martinez

1989

Animal Learning & Behavior

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Tolerance to morphine-induced hypoactivity in hamsters was investigated under conditions designed to test a Pavlovian conditioning model of morphine tolerance. One group of animals received i.p. injections of morphine (50 mg/kg) in the test environment and saline in the home cage; a second group received saline in the test environment and morphine in the home cage; a third group received saline in both environments. A subsequent morphine challenge in the test environment gave evidence of both associative and nonassociative tolerance. Associative tolerance was detectable 1 week later during a second morphine challenge. Compensatory hyperactivity, however, was not observed during a saline challenge in the presence of morphine-associated cues. Following the acquisition of tolerance, nonreinforced exposure to morphine-associated cues produced an attenuation of morphine tolerance (i.e., extinction of tolerance). The results are interpreted as providing partial support for the Pavlovian model and are discussed in terms of alternative associative models of tolerance.

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Section: Discussionmentioning

confidence: 77%

Environmental control of morphine tolerance in the hamster

Schnur

Martinez

1989

Animal Learning & Behavior

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“…However, there is also previous research examining conditioning with amphetamine and haloperidol as an US that resulted in opponent or compensatory responses. Thus, for instance, Poulos, Wilkinson, and Cappell [45] conducted a series of experiments examining tolerance to amphetamine-induced anorexia that revealed the occurrence of a compensatory CR that counteracted the drug effect when it was administered in the same context associated with the drug administration. Similarly, tolerance to haloperidol-induced catalepsy in rats was observed only when the animals were exposed to the context previously associated with the drug [46].…”

Section: Discussionmentioning

confidence: 99%

Prepulse inhibition modulation by contextual conditioning of dopaminergic activity

Mena¹,

Casa²

2013

Behavioural Brain Research

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“…Carlton and Wolgin, 1971;Poulos, Wilkinson and Cappell, 1981; Goudie, 1982, 1983;Streather and Hinson, 1985;Wolgin and Salisbury, 1985;Wolgin, Thompson and Oslan, 1987). Carlton and Wolgin (1971) found that animals given amphetamine chronically developed tolerance to anorexia only if milk was available shortly after each amphetamine injection.…”

Section: Introductionmentioning

confidence: 97%

“…Poulos, Wilkinson and Cappell (1981) suggested that since interaction with a food stimulus (milk) is necessary for tolerance to develop to amphetamine anorexia the loss of tolerance should also require interaction with a food stimulus. This hypothesis was supported in an experiment (Poulos, Wilkinson and Cappell, 1981) in which rats first acquired tolerance to amphetamine anorexia through the contingent procedure. Tolerance was lost by animals who subsequently received saline injections followed by access to milk but was retained by animals who received saline injections but no access to milk.…”

Section: Introductionmentioning

confidence: 98%

Procedures affecting maintenance and loss of tolerance to amphetamine-induced anorexia and cross-tolerance to haloperidol-induced catalepsy

Streather

Hinson

1991

J Psychopharmacol

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Procedures affecting the maintenance and loss of tolerance to amphetamine anorexia were investigated. Following a period in which rats acquired tolerance to amphetamine-induced anorexia via the contingent- tolerance procedure, a variety of manipulations were investigated to determine which effected a loss of tolerance. The procedures included: continued milk availability or its absence, saline injections or no injections and a switch to non-contingent amphetamine injections. These procedures were each investigated while animals continued to be food-deprived or were maintained at their ad libitum weights. The animals maintained at 100% ad lib. lost tolerance whereas tolerance was maintained by the 85% groups, regardless of what other manipulations were given. Subsequently all animals were tested for catalepsy induced by 1.25 mg/kg haloperidol. Animals that had maintained tolerance to amphetamine anorexia (85% groups) were significantly less cataleptic than the animals that had lost tolerance to amphetamine anorexia (100% groups). The finding that tolerance to amphetamine anorexia is lost in animals that have ad lib. access to food indicates that a homeostatic imbalance caused by food-deprivation is perhaps the most important factor in the maintenance of tolerance to amphetamine anorexia.

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Homeostatic regulation and Pavlovian conditioning in tolerance to amphetamine-induced anorexia.

Cited by 97 publications

References 17 publications

Environmental control of morphine tolerance in the hamster

Environmental control of morphine tolerance in the hamster

Prepulse inhibition modulation by contextual conditioning of dopaminergic activity

Procedures affecting maintenance and loss of tolerance to amphetamine-induced anorexia and cross-tolerance to haloperidol-induced catalepsy

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