Homocysteine: A recent potential risk factor for type 2 diabetes mellitus patients in Diyala Province

Abdulhameed, Luay Qasim; Sultan, Ammar Ahmed; Almahdawi, Zaid M. M.

doi:10.1063/5.0112670

Cited by 4 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disturbance glycemic indices could indicate susceptibility to diabetes duo to HHcy which was going in line with [39,40]. HHcy could be induced in diabetic patient with elevation in glucose , lipid profile with decrease in HDL-c and insulin [41].Several observational studies have discovered HHcy as a risk factor for T2DM and related complications [42,43,44].As for the underlying mechanisms, it can be speculated that HHcy might cause oxidative stress, and the increased reactive oxygen species act as functional signaling molecules to activate various stress-sensitive signaling pathways, eventually lead to insulin resistance causing hyperglycemia. [45,46].The generation of ROS by Hcy in the redox-cycling reaction leads to a decrease in the viability of insulin-secreting cells, which in turn results in diminished glucokinase phosphorylation, weakened insulin-secreting response and cell death [47], which are essential components of the pathogenesis of T2DM [48,49].…”

Section: Discussionmentioning

confidence: 70%

Effects of Betaine and Kaempferol On some criteria related to glucose homeostasis in Methionine Over Load Rats -part 2

Ali

2023

wjps

View full text Add to dashboard Cite

This study was designed to evaluate the role of Kaempferol(KPF) and Betaine (BET) in attenuating deleterious effects of methionine overload on some parameters related to diabetes in rats. Thirty (30) adult rats were randomly selected and divided equally into five experimental groups and treated for 45 days as the follows: G1:Rats in this group served as control, Rats in all other groups (G2,G3,G4 and G5 were received 100mg/kg B.W of D-L methionine in drinking water, and received orally as follows: Rats in group G3 were given 150 mg/kg b.w. of KPF, rats in group G4were given 250 mg/kg b.w. BET, rats in group G5 were given 150 mg/kg b.w. of KPF , 250 mg/kg b.w. BET. Fasting blood sample were collected by cardiac puncture technique at the end of the experiments and serum were collected for estimation glycemic indices,. C-peptide and B12 concentration. The results of the experiment that showed given D-L methionine for 45 days(G2group) caused disturbance in glycemic indices as detected by elevation in serum glucose and decrease in serum insulin hormone concentration) and decrease in serum C-peptide and B12 concentration. While oral intubation of KPF and BET or their combination caused correction of all recorded parameters.

show abstract

Section: Discussionmentioning

confidence: 70%

Effects of Betaine and Kaempferol On some criteria related to glucose homeostasis in Methionine Over Load Rats -part 2

Ali

2023

wjps

View full text Add to dashboard Cite

show abstract

“…For instance, an increased circulating plasma C-reactive protein (CRP) [ 5 , 6 ] is noted in patients with T2DM, which may further increase the risk of CVD. Moreover, T2DM are more likely to develop hyperhomocysteinemia primarily due to folate and vitamin B 12 deficiency [ 7 , 8 ]. It is noteworthy to indicate that patients with T2DM who rely on metformin to control hyperglycemia often develop hyperhomocysteinemia, which further makes them susceptible to CVDs [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Folic acid supplementation on inflammation and homocysteine in type 2 diabetes mellitus: systematic review and meta-analysis of randomized controlled trials

Mokgalaboni,

Mashaba,

Phoswa

et al. 2024

Nutr. Diabetes

View full text Add to dashboard Cite

Background The beneficial effects of folate have been observed under different conditions, but the available evidence on inflammation and reduction of cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM) is limited. The study aimed to explore the effects of folate on inflammation and homocysteine amongst individuals with T2DM. Methods PubMed, Scopus, and Cochrane Library were used to search for evidence. A random-effect model meta-analysis through Review Manager (version 5.4) and metaHun was performed. Results were reported as standardized mean differences (SMD) and 95% confidence intervals graphically using forest and funnel plots. Results Data from 9 trials with 426 patients living with T2DM were analyzed. Folic acid supplementation significantly revealed a large effect size on homocysteine levels compared to placebo, SMD = −1.53, 95%CI (−2.14,−0.93), p < 0.05. Additionally, we observed a medium marginal effect size on C-reactive protein (SMD = −0.68, 95%CI (−1.34, −0.01), p = 0.05). However, no significant effect on tumor necrosis factor-α (SMD = −0.86, 95%CI (−2.65, 0.93), p = 0.34), and interleukin-6 (SMD = −0.04, 95%CI (−1.08, 1.01), p = 0.95) was observed. Conclusion Evidence analyzed in this study suggests that folic acid supplementation in T2DM reduces homocysteine and may mitigate CVDs. However, its effect on inflammation is inconclusive.

show abstract

Homocysteine: A Modern Biomarker for Diabetes and Cardiovascular Disease

Abdulhameed,

Sultan,

Kadim

et al. 2024

Int J Basic Sci Med

View full text Add to dashboard Cite

Homocysteine: A recent potential risk factor for type 2 diabetes mellitus patients in Diyala Province

Cited by 4 publications

References 27 publications

Effects of Betaine and Kaempferol On some criteria related to glucose homeostasis in Methionine Over Load Rats -part 2

Effects of Betaine and Kaempferol On some criteria related to glucose homeostasis in Methionine Over Load Rats -part 2

Folic acid supplementation on inflammation and homocysteine in type 2 diabetes mellitus: systematic review and meta-analysis of randomized controlled trials

Homocysteine: A Modern Biomarker for Diabetes and Cardiovascular Disease

Contact Info

Product

Resources

About