2012
DOI: 10.3109/02713683.2012.669512
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Homocysteine and Hydroxyproline Levels in Patients with Primary Open-Angle Glaucoma

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Cited by 24 publications
(22 citation statements)
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“…Since Hcy is a sensitive indicator of vitamin B defi ciency, an elevated Hcy level has been suggested as a marker for a pathogenic process (102) . Recent reports on Hcy measured in AH, plasma, and tear fl uid have yielded mixed results with some studies demonstrating an association with normal tension glaucoma, pseudoexfoliative glaucoma, and POAG, whilst others have not (101,103) . Hcy metabolism is complex with both genetic and environmental factors.…”
Section: Homocysteinementioning
confidence: 99%
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“…Since Hcy is a sensitive indicator of vitamin B defi ciency, an elevated Hcy level has been suggested as a marker for a pathogenic process (102) . Recent reports on Hcy measured in AH, plasma, and tear fl uid have yielded mixed results with some studies demonstrating an association with normal tension glaucoma, pseudoexfoliative glaucoma, and POAG, whilst others have not (101,103) . Hcy metabolism is complex with both genetic and environmental factors.…”
Section: Homocysteinementioning
confidence: 99%
“…Although it is not directly incorporated into proteins, hydroxyproline comprises roughly 4 % of all amino acids found in animal tissue, more than seven amino acids which are directly incorporated (104) . Recently, the levels of Hyp were assessed by spectrometry in the AH and plasma of human eyes with POAG (103) . This study demonstrated that Hyp levels were signifi cantly higher in the AH of POAG patients compared to controls, while no signifi cant difference between the levels of Hyp in plasma of POAG and controls was shown (103) .…”
Section: Hydroxyprolinementioning
confidence: 99%
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“…Another common risk factor seems to be hyperhomocysteinemia (HHcy) [107][108][109]. Homocysteine is a nonprotein amino acid and a metabolic precursor of both methionine and cysteine [110].…”
Section: Glaucoma and Alzheimer's Disease From Epidemiological Relatmentioning
confidence: 99%
“…In the retina, RGCs are immunolabeled with high intensity [104,105]. Interestingly, optineurin was found in neurofibrillary tangles and dystrophic neurites in AD, thus suggesting a new hypothesis for neurodegeneration in AD involving chronic optineurin neurotoxicity and mimicking NTG at the molecular level [106].Another common risk factor seems to be hyperhomocysteinemia (HHcy) [107][108][109]. Homocysteine is a nonprotein amino acid and a metabolic precursor of both methionine and cysteine [110].…”
mentioning
confidence: 99%