Homocysteine and psoriasis

Lin, Xiran; Meng, Xianmin; Song, Zhiqi

doi:10.1042/bsr20190867

Cited by 48 publications

(39 citation statements)

References 141 publications

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“…For example, in psoriatic skin, miR-203 is reported to regulate excessive proliferation and differentiation of keratinocytes through inhibition of the suppressor of cytokine signaling 3 and regulation of cytokine signaling [17]. More importantly, psoriatic arthritis is a major comorbidity of psoriasis, and the reported proportion of psoriatic arthritis among psoriatic patients ranges from 7 to 26% [18]. Previous studies have shown that miR-221-3p is closely associated with psoriatic arthritis [19].…”

Section: Introductionmentioning

confidence: 99%

MiR-221-3p as a Potential Biomarker for Patients with Psoriasis and Its Role in Inflammatory Responses in Keratinocytes

Meng

Qiu²,

Zhang

2021

Skin Pharmacol Physiol

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Introduction: This study investigated serum miR-221-3p levels in psoriatic patients and the characterization of serum miR-221-3p in keratinocyte inflammatory responses was further assessed. Methods: qRT-PCR was used to detect the expression level of miR-221-3p in the serum of 46 patients with psoriasis and 42 healthy controls. The receiver operating characteristic curve evaluated the diagnostic ability of miR-221-3p in psoriasis. The effect of miR-221-3p on HaCaT cell proliferation was detected by using a cell counting Kit-8 and Transwell. ELISA was used to detect serum and keratinocyte pro-inflammatory factors. Results: miR-221-3p was significantly increased in the serum of patients with psoriasis. The area under the curve was 0.861, the sensitivity was 80.4%, and the specificity was 85.7%. Serum miR-221-3p was positively correlated with the expression levels of tumor necrosis factor-α, interleukin (IL)-17A, and IL-22. Cell experiments showed that reducing the expression of miR-221-3p could significantly inhibit cell proliferation. Additionally, miR-221-3p downregulation also inhibited the release of some inflammatory factors in the HaCaT cells. Discussion/Conclusion: MiR-221-3p is a latent biomarker of psoriasis patients. Lower expression of miR-221-3p inhibits the cell proliferation and inflammatory responses of HaCaT cells, which offers a possible target for the therapeutic interventions of psoriasis.

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Section: Introductionmentioning

confidence: 99%

MiR-221-3p as a Potential Biomarker for Patients with Psoriasis and Its Role in Inflammatory Responses in Keratinocytes

Meng

Qiu²,

Zhang

2021

Skin Pharmacol Physiol

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“…Psoriasis is a skin disease associated with a multifactorial profile, as immunological status, environment, and genetic patterns [61][62][63][64][65][66][67]. Nutrition holds a key role as different aliments interact for the development of psoriasis depicted in several studies implicating gut microbiota as well [66][67][68][69][70][71]. The Mediterranean diet (MD) seems to have a positive healthful impact in the development of psoriasis [72,73].…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

Mediterranean Diet as a Tool to Combat Inflammation and Chronic Diseases. An Overview

et al. 2020

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Since ancient times, the quality of nourishment is a milestone for the maintenance of health and as it is stated ‘prevention is better than cure’, amongst the so-called ‘healthy’ diets Mediterranean diet (MD) claims the lion’s share. It stands in good stead because of a variety of valuable macro- and micronutrients. So, adherence to a MD is associated with the reduction of inflammation and non-communicable (NCD) OR chronic diseases. Numerous studies try to scrutinize the role of MD components as regards reducing inflammation, lowering rate, and mortality for disorders and illnesses, and preventing NCD. MD regime of the inhabitants of the Mediterranean basin includes a variety of ethnic nutritional habits and regulates an array of effects and epigenetic changes that affect human wellbeing. The research is still ongoing and endeavors to elucidate every aspect of this issue. This review focuses on the impact of MD on inflammation highlights positive results regarding NCD and indicates the need for more high-quality experiments and trials in order to overcome any discrepancies.

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“…Methotrexate (MTX) is a folate antagonist that inhibits the activity of dihydrofolate reductase activity and is one of the most widely used synthetic drugs in PsA treatment. Unfortunately, its effects on the cardiovascular are diametrically opposed, and, eventually, its prolonged administration may increase serum homocysteine level ( 83 ) and cardiovascular risk in patients with previous hyperhomocysteinemia ( 84 ). Fortunately, increasing homocysteine levels by MTZ can be prevented with folic acid administration ( 83 ) while keeping the anti-inflammatory properties that reduce cardiovascular risk.…”

Section: Relationships and Change In Therapeuticsmentioning

confidence: 99%

Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis

et al. 2021

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Psoriatic arthritis is a chronic inflammatory disease with skin and joint pathology as the dominant characteristics. Scientific evidence supports its systemic nature and relevant relationship with obesity, metabolic syndrome, and associated conditions. Metabolic syndrome and obesity share common signaling pathways with joint inflammation, reinforcing the idea that adipose tissue is a major contributor to disease development and severity. The adipose tissue is not a mere energy store but also an endocrine organ participating in the immune response. In the search for the best therapeutic strategy for a patient, we should appraise the adipose tissue as an endocrine and immune organ responsible for mild chronic inflammation. Today, our challenge is not only to achieve disease remission but to control the associated comorbidities as well. In light of the high prevalence of obesity in psoriatic arthritis patients and the importance of the adipose tissue in the development of chronic inflammation, we aimed to identify the most relevant articles in this regard published in English until June 2020 using the PubMed database. Search terms included psoriatic arthritis, in combination with metabolic syndrome, obesity, adipokines, cardiovascular disease, and treatment. This review summarizes the current evidence regarding the role of adipose tissue as an adipokine-secreting endocrine organ, discussing its influence on disease development and severity, and ultimately in meeting successful disease management.

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Homocysteine and psoriasis

Cited by 48 publications

References 141 publications

MiR-221-3p as a Potential Biomarker for Patients with Psoriasis and Its Role in Inflammatory Responses in Keratinocytes

MiR-221-3p as a Potential Biomarker for Patients with Psoriasis and Its Role in Inflammatory Responses in Keratinocytes

Mediterranean Diet as a Tool to Combat Inflammation and Chronic Diseases. An Overview

Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis

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