Homocysteine and serotonin: Association with postpartum depression

Aishwarya, Sirikonda; Rajendiren, Soundravally; Kattimani, Shivanand; Dhiman, Pooja; Haritha, S.; Ananthanarayanan, PH

doi:10.1016/j.ajp.2013.05.007

Cited by 27 publications

(22 citation statements)

References 21 publications

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“…The symptoms of PPD include reduced interest, poor concentration, sleep deprivation, altered eating pattern, sadness, hopelessness, anxiety, and irritability [ 1 , 2 , 3 , 7 ]. Thus, PPD constitutes an adverse consequence for mothers, children, and families [ 2 , 3 , 7 , 8 , 9 ]. For mothers, PPD is associated with adverse health outcomes (e.g., mental impairment, chronicity of the depression, appetite disorder, decline in sleep quality, and even suicide), and adverse behavioural outcomes (e.g., less responsive caregiving, reduced breastfeeding, less safety concern for their children, rejection of their children, abusive behaviour, and infanticide) [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Duration of Folic Acid Supplementation during Pregnancy and Risk of Postpartum Depression

et al. 2017

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Postpartum depression (PPD), as a common complication of childbearing, could have adverse consequences on mothers, children, and families. This cohort study aimed to assess the association between duration of folic acid (FA) supplementation during pregnancy and the onset of PPD in Chinese women. A total of 1592 participants were recruited, and data collected between July 2015 and March 2017 in Tianjin, China. Participants’ baseline data were collected regarding socio-demographic and lifestyle characteristics, obstetric history, and FA supplementation during pregnancy. The Chinese version of the self-rating depression scale was used to assess depressive symptoms at 6–12 weeks postpartum, and the prevalence of PPD in participants was 29.4%. Pregnant women who took FA supplements for >6 months had a lower prevalence of PPD, compared to those who took FA for ≤6 months. After using the 1:1 ratio propensity score matching, 601 FA-users ≤ 6 months and 601 FA-users > 6 months were included in the further analyses; this also yielded similar results (P < 0.05). Logistic regression analysis showed that FA intake for >6 months was an independent determinant of PPD (odds ratio = 0.76; 95% confidence interval: 0.59–0.98; P < 0.05). Thus, prolonged FA supplementation during pregnancy was associated with a decreased risk of PPD in Chinese women.

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Section: Introductionmentioning

confidence: 99%

Association between Duration of Folic Acid Supplementation during Pregnancy and Risk of Postpartum Depression

et al. 2017

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“…A study has shown a relationship between different serotonin transporter gene alleles and serotonin receptors with mood disorders and depression. [ 37 ] Serotonin is a monoamine neurotransmitter that is synthesized during an enzymatic route from amino acid tryptophan. [ 38 ] The amount of serotonin directly depends on the individual diet.…”

Section: Resultsmentioning

confidence: 99%

“…[ 64 ] In a study, the positive relation between the level of vitamin B2 absorption at week 21 of pregnancy and postpartum depression has been reported. [ 37 ] The results of an ecological study from 23 countries found that increased seafood consumption is associated with reduced risk of postpartum depression.…”

Section: Resultsmentioning

confidence: 99%

Postpartum depression risk factors: A narrative review

Ghaedrahmati

Kazemi

Kheirabadi

et al. 2017

J Edu Health Promot

149

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“…Researchers have shown a relation between depression and hypochondriasis [7,8]; but there is a lack of studies on the prevalence and related factors of hypochondriasis during the pregnancy and postpartum. For now, the precise etiology of PDD and hypochondriasis is unknown; but it is generally believed that biological, genetic, hormonal, and psychological factors are related with them [9][10][11][12][13][14][15][16]. Nutrients like folic acid, vitamin B12, calcium, zinc, selenium, iron, non-saturated greasy acids are considered as signi cant factors [11,14,17].…”

Section: Introductionmentioning

confidence: 99%

“…For now, the precise etiology of PDD and hypochondriasis is unknown; but it is generally believed that biological, genetic, hormonal, and psychological factors are related with them [9][10][11][12][13][14][15][16]. Nutrients like folic acid, vitamin B12, calcium, zinc, selenium, iron, non-saturated greasy acids are considered as signi cant factors [11,14,17]. Nutrition has been proven to play effective role in preventing mental health disorders; the roles include engaging in synthesis and balancing neurotransmitters and catecholamines, activity of enzymes, cellular and oxidative process, function of receptors ,preserving neural tissue and neural functions which are of great signi cance in mental health [18,19].…”

Section: Introductionmentioning

confidence: 99%

Association between dietary intake in each trimester during pregnancy and postpartum depression and hypochondriasis

Kutenaee

Taghavi

Asemi

et al. 2020

Preprint

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Background: The aim of the present study was to assess pregnant mothers' nutritional supply in each trimester and psychological status in postpartum with an emphasis on post pregnancy depression disorder and hypochondriasis.Methods: This was a three-year prospective cohort study that 1319 pregnant women referred to rural health centers in Bandar Abbas, Iran were enrolled. The data were collected using a checklist including socioeconomic and fertility characterize, food frequency questionnaire (FFQ) for measurement of dietary intake, Edinburgh Postnatal Depression Scale (EPDS) to diagnose postpartum depression (PPD), Evans hypochondriasis questionnaire was used to diagnose hypochondriasis.Results: The finding showed that prevalence of PPD and hypochondriasis were 91(6.8%) and 553(42%), respectively. The results showed that intake of iron, selenium, iodine, folate, vitamin C, B12, EPA in all trimesters and intake of vitamin c in second trimester was significantly associated with PPD (P<0.05); as intake of those micronutrients was significantly lower in women with PPD rather than women without that. Moreover, our finding showed that intake of iron, iodine, folate, selenium, EPA in all trimesters was significantly associated with hypochondriasis (P<0.05); as intake of those micronutrients was significantly lower in women with hypochondriasis rather than women without that.Conclusions: Considering the pregnancy and lactation are major nutritional stressors to body and our finding in relation between poor nutrition intake of iron, iodine, folate, selenium, EPA, vitamin C and mood disorders (PPD and hypochondriasis), greeter attention to nutritional factors in psychological status during postpartum is warranted.

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Homocysteine and serotonin: Association with postpartum depression

Cited by 27 publications

References 21 publications

Association between Duration of Folic Acid Supplementation during Pregnancy and Risk of Postpartum Depression

Association between Duration of Folic Acid Supplementation during Pregnancy and Risk of Postpartum Depression

Postpartum depression risk factors: A narrative review

Association between dietary intake in each trimester during pregnancy and postpartum depression and hypochondriasis

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