Homocysteine and serum lipids concentration in male war veterans with posttraumatic stress disorder

Jendričko, Tihana; Vidović, Anđelko; Grubišić-Ilić, Mirjana; Romić, Željko; Kovačić, Zdenko; Kozarić‐Kovačić, Dragica

doi:10.1016/j.pnpbp.2008.11.002

Cited by 43 publications

(28 citation statements)

References 60 publications

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“…Jendricko T et al found that war veterans who were nonsmokers had higher Hcy levels than did smokers [14]. Other studies found a positive correlation between Hcy levels and tobacco use [15] and significantly lower plasma concentrations of pyridoxal phosphate in smokers compared with non-smokers [16]. Smokers with high plasma Hcy are at greatly increased risk of CVD.…”

Section: Discussionmentioning

confidence: 99%

Total homocysteine levels and cardiovascular risk factors in healthy Tunisians

Oudi¹,

Aouni²,

Mazigh³

et al. 2011

East Mediterr Health J

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Hyperhomocysteinaemia is considered as an important independent risk factor for atherosclerosis and thrombotic disease. This study determined the distribution of homocysteine (Hcy) levels in healthy Tunisian subjects and evaluated the relationship between Hcy levels and some cardiovascular risk factors. Randomly selected subjects (592 men and 114 women) were recruited from different regions of Tunisia. The overall mean Hcy level was 12.6 (SD 5.4) µmol/L. Hcy levels in subjects with hyperhomocysteinaemia varied according to geographical region. Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B 12 levels compared with subjects with normohomocysteinaemia. Hcy levels correlated with total cholesterol (r = 0.09), apolipoprotein A (r = 0.012), and B (r = 0.013) levels and total/HDL cholesterol ratio (r = -0.085). Further epidemiological studies are needed to determine the precise role of Hcy in cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Total homocysteine levels and cardiovascular risk factors in healthy Tunisians

Oudi¹,

Aouni²,

Mazigh³

et al. 2011

East Mediterr Health J

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“…It has been known for a long time that prolonged stress plays a major role in increasing the blood levels of triglycerides in animals, as well as in humans (14,21). A human study concerning psychological and mental stress showed that these cause triglycerides to stay in the bloodstream for longer, contributing to cardiovascular health problems (23).…”

Section: Discussionmentioning

confidence: 99%

Influence of 8-Hour Road Transportation on Selected Physiological Parameters in Horses

Niedźwiedź

Zawadzki

Filipowski

et al. 2012

Bulletin of the Veterinary Institute in Pulawy

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The objective of this study was to assess the physiological responses in mature healthy horses prior to an 8 h transport, as well as immediately and 24 h after transportation in a horse truck, under autumn conditions typical for central Poland. The study was conducted on a group of 60 horses of different breed. Horses ranged from 4 to 10 years of age. Venous blood was taken 3 times: Idirectly before loading the horses to the trailer, II -directly after unloading the horses from the trailer, III -after period of 24 h resting. There was no change in the concentrations of urea, cholesterol, creatinine, and magnesium and in the activity of alkaline phosphatase during the three subsequent samplings. Albumin, total protein, alanine aminotransferase, aspartate aminotransferase, total bilirubin, creatine kinase, and triglycerides were mostly influenced by the transport. The obtained results indicate that the transportation of horses alters concentrations of physiological variables of their metabolism.

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“…Moreover, it was found that the levels of TC, TG and LDL-C were elevated but the level of HDL-C was reduced in war veterans with chronic PTSD when compared with healthy control subjects (9)(10)(11). However, in other studies, no significant differences were found in the levels of serum TC, LDL-C and HDL-C between veterans with and without PTSD (12). The mechanisms of these discrepancies have not been elucidated yet.…”

Section: Introductionmentioning

confidence: 92%

“…Analyses of covariance (ANCOVA) with age, gender and BMI as covariates were used to analyze the differences of TC, TG, HDL-C, LDL-C and glucose in subjects with and without PTSD or/and with different genotypes of TrkB rs1187327. Age, gender and BMI were used as covariates because impacts of these variables were observed on serum lipids concentrations (12,32). All statistical analyses were 2-tailed with p ≤ 0.05 as the level of significance.…”

Section: Dna Extraction and Genotypingmentioning

confidence: 99%