Homocysteine, estrogen and cognitive decline

Shah, Sonal; Bell, Robin Jean; Davis, Susan Ruth

doi:10.1080/13697130600641282

Cited by 15 publications

(4 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Methionine is a sulfur-containing essential amino acid that converts to homocysteine after donating the methyl group in cellular methylations (48). In vitro assays suggested that estrogen may regulate homocysteine levels through conjugation processes (49,50). Although the systemic interactions between methionine/homocysteine and estrogen (its receptors) are complex and unclear (51), based on clinical investigations comparing pregnant, premenopausal and postmenopausal women with estrogen replacement therapy (ERT) with age-matched men and postmenopausal women without ERT, the 3 rd National Health and Nutrition Examination Survey has recognized the inverse relationship between serum estrogen and homocysteine (52).…”

Section: Discussionmentioning

confidence: 99%

Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis

Sukul,

Fischer,

Broderius

et al. 2024

Preprint

View full text Add to dashboard Cite

Menopause driven decline in estrogen exposes women to risk of osteoporosis. Detection of early onset and silent progression are keys to prevent fractures and associated burdens. In a discovery cohort of 120 postmenopausal women (aged: 49 – 90 years), we combined repeated quantitative pulse-echo ultrasonography of bone, assessment of grip strength and serum bone markers with mass-spectrometric analysis of exhaled metabolites to find breath volatile markers and quantitative cutoff levels for osteoporosis. Obtained markers and cutoffs were validated in an independent cohort of 49 age-matched women with 6 months apart seasonal follow-ups. Within the discovery cohort median concentrations (ppbV) of exhaled end-tidal dimethyl sulfide (DMS), allyl-methyl sulfide, butanethiol and butyric acid increased significantly (p≤0.005) by 45.24%, 42.83%, 38.29% and 33.66% in subjects (n=27) with bone density at high-risk of osteoporosis and fracture, when compared to subjects (n=62) with normal bone mineral density (BMD). Increased age and decreased grip strength were concomitant. All these changes were reproduced within the independent validation cohort including seasonal follow-ups. Exhaled metabolite expressions remained age independent in either cohort. Serum bone markers showed random expressions without any reproducibility. DMS exhalations even differed between patients with recent (<1 year), old and without fractures. Metabolite exhalations and BMDs were down-regulated during winter mirroring the regional climate change. ROC analysis in the discovery cohort yielded high classification accuracy (AUC=0.86) of DMS with a cutoff at 15.88 ppbV for osteoporosis, which predicted subjects at high-risk within the independent validation cohort with high (>91%) sensitivity and specificity during both follow-ups. Non-invasive analysis of exhaled DMS allowed more reliable classification of osteoporosis risk than conventional serum bone markers. We identified associations of exhaled organosulfur and short-chain fatty acid markers to bone metabolism in postmenopausal osteoporosis via a gut-bone axis.

show abstract

Section: Discussionmentioning

confidence: 99%

Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis

Sukul,

Fischer,

Broderius

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…One study has shown a modest decrease in homocysteine levels with raloxifene therapy. 35 In this study, we chose to consider words A and words B results together. Words A are simple words and words B are abstract words.…”

Section: Discussionmentioning

confidence: 99%

Raloxifene improves verbal memory in late postmenopausal women

Jacobsen¹,

Samson²,

Emmelot-Vonk³

et al. 2010

Menopause

View full text Add to dashboard Cite

show abstract

“…113,114 También puede ser un evento clave en el riesgo de demencia en el climaterio y la menopausia. 115 Hiperhomocistinemia y tejidos conectivos: autoinmunidad y osteoporosis…”

Section: Hiperhomocistinemia Y Neurodesórdenesunclassified

Biología, patobiología y bioclínica de la homocisteína eh la especie humana

García¹

2010

Repert. Med. Cir.

View full text Add to dashboard Cite

La homocistinuria fue descrita en 19a2 en niños con dificultades de aprendizaje y en 19a9 McCully informó la evidencia en autopsias de trombosis arterial eztensa y aterosclerosis en niños con elevadas concentraciones de homocisteína plasmática y homocistinuria. La homocisteína, un aminoácido de azufre, es un metabolito intermedio de la metionina, y sobre la base de estos hallazgos bioquímicos, ellos propusieron que la homocisteína plasmática elevada puede causar lesión neural y enfermedad vascular aterosclerótica. Hoy se considera un factor de riesgo independiente para esta última. La hiperhomocistinemia leve es bastante prevalente en la población general. Puede deberse a defectos genéticos en las enzimas que participan en el metabolismo de la homocisteína, carencias nutricionales de vitaminas y cofactores, ciertos medicamentos, ingesta rica en metionina o enfermedad renal. La alta concentración puede reducirse con folato, y es así que la suplementación vitamínica ha sido propuesta en individuos con hiperhomocistinemia con el fin de reducir su riesgo de enfermedad cardiovascular. En este artículo hacemos una revisión de la biología, la patobiología y la bioclínica del metabolismo de la homocisteína.

show abstract

Homocysteine, estrogen and cognitive decline

Cited by 15 publications

References 78 publications

Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis

Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis

Raloxifene improves verbal memory in late postmenopausal women

Biología, patobiología y bioclínica de la homocisteína eh la especie humana

Contact Info

Product

Resources

About