Homocysteine in women's health

Løbo, Rogerio A.

doi:10.1097/01.gme.0000072222.06570.94

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…16 Sex steroids appear to influence Hcy metabolism. 17 Hcy levels are lower in women than in men of comparable age, 18 and in premenopausal compared to postmenopausal women. 17 Although Hcy levels increase significantly after menopause, 19 age cannot be excluded as a confounding factor.…”

Section: Introductionmentioning

confidence: 79%

“…17 Hcy levels are lower in women than in men of comparable age, 18 and in premenopausal compared to postmenopausal women. 17 Although Hcy levels increase significantly after menopause, 19 age cannot be excluded as a confounding factor. 20 High Hcy levels among postmenopausal women may be associated with an estrogen-depletion mediated effect or with an age-related evolution of Hcy metabolism.…”

Section: Introductionmentioning

confidence: 79%

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Endogenous sex steroids and circulating homocysteine in healthy Greek postmenopausal women

Christodoulakos¹,

Lambrinoudaki²,

Rizos³

et al. 2006

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Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 79%

Endogenous sex steroids and circulating homocysteine in healthy Greek postmenopausal women

Christodoulakos¹,

Lambrinoudaki²,

Rizos³

et al. 2006

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“…1 Although women have been included in meta-analyses of randomized trials, 3,6 the relative risks (RRs) for women have not been separately estimated. Given the paucity of data on women and the known influences of estrogen on homocysteine levels, 7,8 adequately powered randomized trials of homocysteine lowering in women are still needed. 9 The present study, the Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS), tested whether a combination of folic acid, vitamin B 6 , and vitamin B 12 would reduce total cardiovascular events among women at high risk for the development of CVD over 7.3 years of follow-up.…”

mentioning

confidence: 99%

Effect of Folic Acid and B Vitamins on Risk of Cardiovascular Events and Total Mortality Among Women at High Risk for Cardiovascular Disease

Chen¹,

Cook²,

Gaziano³

et al. 2008

JAMA

454

342

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OMOCYSTEINE LEVELS HAVEbeen directly associated with cardiovascular risk in observational studies 1 ; and daily supplementation with folic acid, vitamin B 6 , vitamin B 12 , or a combination have been shown to reduce homocysteine levels to varying degrees in intervention studies. 2 Based on these data, several randomized trials were designed to test the hypothesis that supplementation with folic acid or B vitamins or both would prevent cardiovascular disease (CVD). However, published trials on patients with preexisting vascular disease have not demonstrated a benefit of folic acid or B vitamins on CVD risk. 3 Participants in observational studies were followed up for longer durations then participants in randomized trials 1 ; therefore, it is plausible that homocysteine lowering may have had a greater effect if participants were treated and observed for longer periods of time. Metaanalyses of randomized trials sug-For editorial comment see p 2086.

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“…Additionally, homocysteine concentration was associated with sex. [ 13 , 14 ] Females had lower homocysteine levels than males. [ 15 – 18 ] But females were more susceptible to the damaging effect of homocysteine in vascular diseases, such as the risk of ischemic stroke and poor prognosis (death and major disability) of acute ischemic stroke, than males.…”

Section: Introductionmentioning

confidence: 99%

Relationship between homocysteine levels and post-stroke cognitive impairment in female and male population: from a prospective multicenter study

Weng

Pan

et al. 2021

Journal of Translational Internal Medicine

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Background and Objectives: To investigate the relationship between homocysteine levels and post-stroke cognitive impairment (PSCI) in Chinese female and male populations with minor acute ischemic stroke or transient ischemic attack. Materials and methods: A total of 1070 participants with clinically confirmed acute minor ischemic stroke or transient ischemic attack and baseline homocysteine information from a nationwide multicenter prospective registry study in China were included in this study. Of these, 919 patients had cognitive assessments at 3-month follow-ups and 584 participants had cognitive assessments at 12-month follow-ups. The incidence of PSCI was defined as a Montreal Cognitive Assessment score ≤22. The differences in homocysteine levels and the incidence of PSCI were compared between female and male populations. Relationships between homocysteine levels and the incidence of PSCI in female and male populations were analyzed using multiple logistic regression, respectively. Results: Females had lower baseline homocysteine levels than males. Compared to males, females had lower education levels, lower rates of smoking and alcohol intake, and higher rates of diabetes and hypertension. No relationship was observed between elevated homocysteine level and 3-month PSCI incidence in either females or males. After adjusting the confounders, elevated baseline homocysteine significantly increased the 12-month PSCI risk (odds ratio 3.28, 95% confidence interval 1.47–7.34, P = 0.004) in females, but not in males (odds ratio 0.86, 95% confidence interval 0.49–1.49, P = 0.586). Conclusion: Elevated homocysteine levels increased the 12-month PSCI risk in females, but not in males with minor acute ischemic stroke or transient ischemic attack.

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Homocysteine in women's health

Cited by 8 publications

References 24 publications

Endogenous sex steroids and circulating homocysteine in healthy Greek postmenopausal women

Endogenous sex steroids and circulating homocysteine in healthy Greek postmenopausal women

Effect of Folic Acid and B Vitamins on Risk of Cardiovascular Events and Total Mortality Among Women at High Risk for Cardiovascular Disease

Relationship between homocysteine levels and post-stroke cognitive impairment in female and male population: from a prospective multicenter study

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