In this analysis, the thermal and flow properties of modified hybrid nanofluids (MNFs) have been investigated under the effects of electroosmosis and homogeneous-heterogeneous chemical reactions. Three types of nanoparticles of Cu, CuO, and Al2O3 are utilized to monitor the performance of the MNFs with water as a working liquid. The determination of the heating phenomenon is explored by incorporating the effects of NPs shape, temperature reliant viscosity, Joule heating, heat generation/absorption and viscous dissipation. In this exploration, equal diffusion factors for the auto catalyst and reactants are assumed. The model formulation contains a highly non-linear PDE system, which is converted to ODEs under physical assumptions with lubrication and Debye–Huckel. The solution treatment involves the Homotopy perturbation method for solving the governing differential equations is used. A major outcome discloses that an addition in heterogeneous reaction parameter aids in enhancing the concentration profile. In a result, the temperature curve decreases at increasing volume fraction of the NPs. Modified hybrid NFs have higher heat transfer rate as compared to base H20, or ordinary Al2O3–H20 and hybrid Cu + Al2O3–H20 NFs. Pressure gradient decreases by improving electroosmotic parameter. Further a comparison between analytically (HPM) and numerical results (NDSolve) show that both results are in good agreement.