Honey and quercetin reduce ochratoxin A-induced DNA damage in the liver and the kidney through the modulation of intestinal microflora

Oršolić, Nada; Jembrek, Maja Jazvinšćak; Terzić, Svjetlana

doi:10.1080/09540105.2017.1313819

Cited by 26 publications

(36 citation statements)

References 61 publications

(137 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Q is a member of the flavonoids family and it is well known that Q has wide bioactivity, including hypolipidemic and antioxidant properties. Previous studies have reported that Q showed a protective effect against the toxic effect of mycotoxins such as aflatoxin [ 156 , 157 ], OTA [ 158 , 159 , 160 ], T2 [ 161 ], zearalenone [ 162 , 163 ], and alternariol [ 164 ]. Round-shaped nanoparticles consisting of quercetin showed a protective effect on OTA-treated rats (3 mg/kg diet).…”

Section: Nano Approaches For Mycotoxin Risk Eliminationmentioning

confidence: 99%

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

et al. 2018

View full text Add to dashboard Cite

Mycotoxins are toxic secondary metabolites produced by certain filamentous fungi. The occurrence of mycotoxins in food and feed causes negative health impacts on both humans and animals. Clay binders, yeast cell walls, or antioxidant additives are the most widely used products for mycotoxin elimination to reduce their impact. Although conventional methods are constantly improving, current research trends are looking for innovative solutions. Nanotechnology approaches seem to be a promising, effective, and low-cost way to minimize the health effects of mycotoxins. This review aims to shed light on the critical knowledge gap in mycotoxin elimination by nanotechnology. There are three main strategies: mold inhibition, mycotoxin adsorption, and reducing the toxic effect via nanoparticles. One of the most promising methods is the use of carbon-based nanomaterials. Graphene has been shown to have a huge surface and high binding capacity for mycotoxins. Attention has also been drawn to polymeric nanoparticles; they could substitute adsorbents or enclose any substance, which would improve the health status of the organism. In light of these findings, this review gives new insights into possible future research that might overcome challenges associated with nanotechnology utilization for mycotoxin elimination from agricultural products.

show abstract

Section: Nano Approaches For Mycotoxin Risk Eliminationmentioning

confidence: 99%

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

et al. 2018

View full text Add to dashboard Cite

show abstract

“…We observed that exposure to low OTA doses induced substantial changes in the diversity and composition of gut microbiota. The unique study in mice used culture-dependent methods to investigate the effect of OTA on the growth of colonic probiotic bacteria [ 36 ]. This approach has great limitations since the majority of intestinal bacteria are widely considered to be unculturable and have never been isolated in the laboratory.…”

Section: Discussionmentioning

confidence: 99%

“…Although the mouse is the most commonly used organism in basic and experimental research, only one study has investigated the effect of OTA on the growth of colonic probiotic bacteria in mice [ 36 ]. However, culture-dependent methods have limitations since the majority of intestinal bacteria are widely considered to be unculturable and have never been isolated in the laboratory.…”

Section: Introductionmentioning

confidence: 99%

Oral Sub-Chronic Ochratoxin a Exposure Induces Gut Microbiota Alterations in Mice

Izco

Vettorazzi

Toro

et al. 2021

Toxins

View full text Add to dashboard Cite

Gut microbiota plays crucial roles in maintaining host health. External factors, such as diet, medicines, and environmental toxins, influence the composition of gut microbiota. Ochratoxin A (OTA) is one of the most prevalent and relevant mycotoxins and is a highly abundant food and animal feed contaminant. In the present study, we aimed to investigate OTA gut microbiome toxicity in mice sub-chronically exposed to low doses of OTA (0.21, 0.5, and 1.5 mg/kg body weight) by daily oral gavage for 28 days. Fecal microbiota from control and OTA-treated mice was analyzed using 16S ribosomal RNA (rRNA) gene sequencing followed by metagenomics. OTA exposure caused marked changes in gut microbial community structure, including the decrease in the diversity of fecal microbiota and the relative abundance of Firmicutes, as well as the increase in the relative abundance of Bacteroidetes at the phylum level. At the family level, six bacterial families (unclassified Bacteroidales, Porphyromonadaceae, unclassified Cyanobacteria, Streptococcaceae, Enterobacteriaceae, Ruminococcaceae) were significantly altered by OTA exposure. Interestingly, OTA-induced changes were observed in the lower-dose OTA groups, while high-dose OTA group microbiota was similar to control group. Our results demonstrated that sub-chronic exposure at low doses of OTA alters the structure and diversity of the gut microbial community.

show abstract

“…Previously, Ganash, Mujallid, Al‐Robai, and Bazzaz () found that deleterious pathological effects of doxorubicin in mice (including effects on liver function) are ameliorated by co‐treatment with honey (5 ml kg −1 day −1 ). Oršolić, Jembrek, and Terzić () found that DNA damage in the liver and kidney induced by ochratoxin treatment (100 μg kg −1 day −1 ) in mice is reduced if the treatment is immediately preceded by administration of honey (2 g kg −1 day −1 ). In addition, Haron and Mohamed () observed that restraint stress in pregnant rats has adverse effects on testicular and epididymal weights and sperm parameters in male offspring, but these effects are reduced by administration of honey during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Triclosan treatment to pregnant albino rats affects offspring numbers and the liver of both the pregnant rats and their offspring, and these effects are ameliorated by co‐treatment with bee honey

Hanafy

Abo-Ouf

Mohamed

et al. 2020

The Anatomical Record

View full text Add to dashboard Cite

We have assessed the effects of the broad‐spectrum bactericide triclosan on the liver of pregnant albino rats and their offspring, and evaluated the protective potential of bee honey, which has radical‐scavenging properties. The study involved treatment of 72 pregnant rats followed by examination of the pregnant rats and their offspring. The pregnant rats were divided equally into six groups (I–VI), each of which was subdivided equally into two Subgroups (A and B). Rats in the A subgroups were gavaged with a daily dose of 1.26 ml distilled water (IA), 1 ml corn oil (IIA), 1.68 ml aqueous solution of Clover Blossom honey (IIIA), 0.3 mg triclosan (IVA), 13 mg triclosan (VA), or 1.68 ml aqueous solution of honey with 13 mg triclosan (VIA), throughout pregnancy. Rats in the B subgroups received the same treatments throughout pregnancy and for 14 days after delivery. At the end of the experiments, the offspring's numbers were recorded and blood samples were taken from the pregnant rats for analysis. The livers of the studied groups were subjected for; histological study, morphometric analysis, and biochemical estimation of markers of oxidative stress. The results showed that the acceptable daily intake of triclosan did not induce significant pathological changes in the liver while high dose of triclosan induced pathological changes in the livers and reduced the numbers of offspring. Co‐administration of honey with triclosan ameliorated most pathological change. Therefore, decrease the exposure of the pregnant women to triclosan is encouraged or co‐supplementation with bee honey if exposure could not be avoided.

show abstract

Honey and quercetin reduce ochratoxin A-induced DNA damage in the liver and the kidney through the modulation of intestinal microflora

Cited by 26 publications

References 61 publications

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

Oral Sub-Chronic Ochratoxin a Exposure Induces Gut Microbiota Alterations in Mice

Triclosan treatment to pregnant albino rats affects offspring numbers and the liver of both the pregnant rats and their offspring, and these effects are ameliorated by co‐treatment with bee honey

Contact Info

Product

Resources

About