Honeycomb-Structured Porous Films from Polypyrrole-Containing Block Copolymers Prepared via RAFT Polymerization as a Scaffold for Cell Growth

Beattie, Danelle; Wong, Kam Cheong; Williams, Charles M.; Poole-Warren, Laura A.; Davis, Thomas P.; Barner‐Kowollik, Christopher; Stenzel, Martina H.

doi:10.1021/bm050858m

Cited by 200 publications

(167 citation statements)

References 47 publications

(99 reference statements)

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“…In our laboratory, we observed the growth of fibroblast L929 cells, using conducting block copolymers. 41 A dense film without any pores did not show any cell attachment. A honeycomb-structured film, in contrast, clearly led to the attachment of cells.…”

Section: Applicationsmentioning

confidence: 89%

Formation of honeycomb‐structured, porous films via breath figures with different polymer architectures

Stenzel

Barner‐Kowollik

Davis

2006

J. Polym. Sci. A Polym. Chem.

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295

272

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Honeycomb-structured, porous films with pore sizes ranging from 200 nm to 7 lm were prepared with breath figures. The regularity of the hexagonal array and the pore size was influenced by the polymer architecture and the casting conditions. A nanoscaled suborder next to the microarray was obtained with amphiphilic block copolymers. These films were shown to be suitable as surfaces for cell growth.

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Section: Applicationsmentioning

confidence: 89%

Formation of honeycomb‐structured, porous films via breath figures with different polymer architectures

Stenzel

Barner‐Kowollik

Davis

2006

J. Polym. Sci. A Polym. Chem.

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295

272

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“…[14] A more general review on the formation and applications of honeycomb polymers by the breath figure approach has also been published. [253] Recent reports include honeycomb structures formed by assembly of polypyrrole-containing block copolymers [254] and comb polymers formed by grafting polystyrene from cellulose. [255] The former have been suggested as scaffolds for cell growth.…”

Section: Supramolecular Structuresmentioning

confidence: 99%

Living Radical Polymerization by the RAFT Process—A First Update

Moad¹,

Rizzardo²,

Thang³

2006

Aust. J. Chem.

859

787

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This paper provides a first update to the review of living radical polymerization achieved with thiocarbonylthio compounds (ZC(=S)SR) by a mechanism of Reversible Addition-Fragmentation chain Transfer (RAFT) published in June 2005. The time since that publication has witnessed an increased rate of publication on the topic with the appearance of well over 200 papers covering various aspects of RAFT polymerization ranging over reagent synthesis and properties, kinetics, and mechanism of polymerization, novel polymer syntheses, and diverse applications.

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“…In earlier studies, [ 1,3,[12][13][14]32,33 ] honeycomb-patterned porous fi lms have been proven to be excellent candidates as scaffolds for cell culture applications owing to their greatly enlarged surface area and regular pores with narrow size distribution, which are favorable for cell attachment and spreading. However, only hydrophilic surface is suitable for cell adhesion and growth as most of the cells cannot attach on hydrophobic surface.…”

mentioning

confidence: 99%

CO₂‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion

Yin

Bulteau

Feng

et al. 2016

Adv Materials Inter

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of developing different polymers to fabricate honeycomb fi lms with different surface wettability. The reversible control of wettability enables fi lms to be recycled and reused, as a result, the production cost will be largely reduced. Moreover, adjustable wettability of interfacial materials has versatile potentials in many applications, such as controlled drug delivery, cells capture and release, and oil/water separation, in which wettability acts as a switch. [ 15 ] Therefore, development of honeycomb fi lms with tunable and reversible surface wettability is of great importance for both fundamental research and practical applications.Wettability is largely dependent on surface structure and chemical composition of the materials. [ 13,16,17 ] Generally, honeycomb fi lm surface exhibits hydrophobic characteristics derived from the hydrophobic polymer and the presence of micron-sized holes which is similar to the "lotus-effect" of plant leaves. [ 13,18 ] Considering the special morphology of honeycomb fi lms, introduction of stimuli-responsive groups on fi lm surface makes it an appropriate way to realize the adjustment of surface wettability since the reversible physical properties change can be easily achieved upon exposure to external stimulation. Hence, two approaches have been developed to introduce sensitive groups on honeycomb fi lm surface. One is based on the strategy of posttreatment on an as-prepared fi lm. [ 1,5,13 ] That is, to prepare a normal honeycomb fi lm fi rst and then stimuli-responsive moieties are introduced by further surface modifi cation. For example, Stenzel and co-workers prepared the fi rst example of thermoresponsive honeycomb structured porous polymer fi lm by grafting poly( N -isopropylacrylamide) (PNIPAAm) onto a honeycomb fi lm via reversible additionfragmentation transfer polymerization. [ 13 ] The modifi ed fi lm surface changes from hydrophobic to hydrophilic when temperature declines from 45 to 25 °C. However, postmodifi cation on honeycomb fi lm is, in fact, rather complicated, usually including several steps. In contrast, the strategy that directly employs stimuli-responsive polymer to fabricate honeycomb fi lm with smart surface is more preferred due to its simplicity and effi ciency. [ 16,17,19,20 ] In this case, the hydrophilic sensitive groups concentrate on the inner surfaces of the pores or further form nanophase structures inside the walls of the honeycomb fi lms, thereby conferring the fi lms tunable surfaces wettability. [ 16,19 ] For instance, Hu and co-workers reported the fi rst pH-responsive honeycomb fi lm by polystyrene-b -polyacrylic acid (PS-b -PAA) self-assembly. [ 17 ] The water contact angle (CA) of the original fi lm with 1.5 µm pore diameter is 96°, while it increases to 120° after the treatment with an acid aqueous solution (pH 4.0), it sharply decreases to 10° after the treatment of a base aqueous solution (pH 10.0), ascribing to the protonation of carboxylic acid groups that leads to an increase of hydrophilicity. Later, Billon and co-workers [ 19...

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Honeycomb-Structured Porous Films from Polypyrrole-Containing Block Copolymers Prepared via RAFT Polymerization as a Scaffold for Cell Growth

Cited by 200 publications

References 47 publications

Formation of honeycomb‐structured, porous films via breath figures with different polymer architectures

Formation of honeycomb‐structured, porous films via breath figures with different polymer architectures

Living Radical Polymerization by the RAFT Process—A First Update

CO₂‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion

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Honeycomb-Structured Porous Films from Polypyrrole-Containing Block Copolymers Prepared via RAFT Polymerization as a Scaffold for Cell Growth

Cited by 200 publications

References 47 publications

Formation of honeycomb‐structured, porous films via breath figures with different polymer architectures

Formation of honeycomb‐structured, porous films via breath figures with different polymer architectures

Living Radical Polymerization by the RAFT Process—A First Update

CO2‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion

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CO₂‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion