Honeys as Possible Sources of Cholinesterase Inhibitors

Szwajgier, Dominik; Baranowska‐Wójcik, Ewa; Winiarska-Mieczan, Anna; Gajowniczek-Ałasa, Dorota

doi:10.3390/nu14142969

Cited by 10 publications

(10 citation statements)

References 39 publications

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“…Such positive effects were attributed by the authors to the presence of polyphenols. More recently, Szwajgier et al 37 evidenced the potential benefits of nineteen types of honey, which can represent an important font of cholinesterase inhibitors, playing a role in the Alzheimer disease. Honey also inhibits the growth of pathogens, which presence and diffusion can damage the Central Nervous System.…”

Section: Resultsmentioning

confidence: 99%

In vitro prospective healthy and nutritional benefits of different Citrus monofloral honeys

Fratianni

Amato

d’Acierno

et al. 2023

Sci Rep

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We studied the total polyphenols, flavonoids, vitamin C, the antioxidant and anti-inflammatory activity of six Citrus monofloral honey, and the in vitro inhibitory effect against cholinesterases and tyrosinase. Finally, we assessed their effect against the biofilm of some pathogenic bacteria. Lime honey showed the best antioxidant activity and the highest content of polyphenols and vitamin C. Lemon and tangerine honey contained almost exclusively flavonoids. Lemon honey better preserved the bovine serum albumin against denaturation (IC50 = 48.47 mg). Honeys inhibited acetylcholinesterase, butyrylcholinesterase, and tyrosinase up to 12.04% (tangerine), 19.11% (bergamot), and 94.1% (lemon), respectively. Lime and clementine honey better inhibited the Listeria monocytogenes biofilm. Bergamot honey acted mainly against the Staphylococcus aureus and Acinetobacter baumannii biofilm; bergamot and tangerine honey inhibited the Pseudomonas aeruginosa biofilm particularly. Bergamot, clementine, and tangerine honey acted against Escherichia coli sessile cell metabolism. This Citrus honey exhibited in vitro prospective health benefits and is applicable for future in vivo studies.

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Section: Resultsmentioning

confidence: 99%

In vitro prospective healthy and nutritional benefits of different Citrus monofloral honeys

Fratianni

Amato

d’Acierno

et al. 2023

Sci Rep

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“…Only six in vitro articles were found related to the search topic. Of the six in vitro honey studies, two in vitro articles [ 29 , 30 ] investigated AD and PD, whereas three in vitro articles [ 31 , 32 , 33 ] specifically targeted AD only. One in vitro study [ 34 ] investigated the relationship between honey and neurodegeneration.…”

Section: Resultsmentioning

confidence: 99%

“…The inhibition of BChE has been reported to treat advanced AD [ 45 ]. A recent study assessed nineteen honey varieties’ inhibitory activity on AChE and BChE using Ellman’s colorimetric approach [ 33 ]. Thyme and Goldenrod honey significantly inhibit AChE and BChE with the highest degree of inhibition of 21.17% and 34%, respectively, raising the prospect that honey may be utilized as a future AD treatment.…”

Section: Discussionmentioning

confidence: 99%

The Potential Use of Honey as a Neuroprotective Agent for the Management of Neurodegenerative Diseases

2023

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As the global population ages, there is an increasing research on managing neurodegenerative diseases that mainly affect the elderly. Honey is one of the natural products and functional foods widely studied for its neuroprotective properties. This review investigates honey’s effectiveness as a neuroprotective agent through in vitro, in vivo, and clinical research. The articles were browsed from three databases (PubMed, ScienceDirect, and Scopus) between the years of 2012 and 2022 using the keywords “honey” crossed with “neurodegenerative”. Out of the 16 articles, six in vitro, eight in vivo, one combination study, and one clinical intervention were compiled. Among the various types of honey studied, the Tualang and Thyme honey exhibited the highest antioxidant, anti-inflammatory, and anticholinesterase activity, leading to the prevention and management of multiple neurodegenerative diseases such as Alzheimer’s disease. The neuroprotective properties of honey are primarily attributed to its high polyphenol content, with quercetin and gallic acid being the most prominent. This review compiled considerable evidence of the anti-neurodegenerative properties of honey presented by in vitro and in vivo studies. However, more clinical intervention studies are required to support these findings further.

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“…[60] There are limited studies on the evaluation of the acetylcholinesterase (AChE) and tyrosinase inhibition activities of SH. Szwajgier et al [61] reported the AChE inhibition activity range between 14 % and 16 % and BChE inhibitory activity between 18 % and 20 % in Ukraine SH. The anti-tyrosinase activity of two SHs from different regions of Thailand was found as 46.64 % and 52.12 %.…”

Section: Anticholinesterase Anti-urease Anti-tyrosinase and Antiinfla...mentioning

confidence: 99%

HPLC‐DAD Analysis and Versatile Bioactivities of Turkish Sunflower Honeys Using Chemometric Approaches

Duru

Eroğlu

Tel‐Çayan

et al. 2023

Chemistry & Biodiversity

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Sunflower honey (SH) is bright yellow, fragrant, pollen‐flavoured, slightly herbaceous and has a unique taste. The present research aims to examine the enzyme inhibitory, antioxidant, anti‐inflammatory, antimicrobial and anti‐quorum sensing activities and phenolic compositions of 30 sunflower honeys (SHs) produced from several regions of Turkey with chemometric study. SAH from Samsun exhibited the best antioxidant activity in β‐carotene linoleic acid (IC50: 7.33±0.17 mg/mL) and CUPRAC (A0.50: 4.94±0.13 mg/mL) assays, anti‐urease activity (60.63±0.87 %) and anti‐inflammatory activity against COX‐1 (73.94±1.08 %) and COX‐2 (44.96±0.85 %). SHs exhibited mild antimicrobial activity against the test microorganisms while they showed high quorum sensing inhibition zones measured in the range of 42–52 mm against the CV026 strain. The phenolic composition was determined by high performance liquid chromatography with diode array detection (HPLC‐DAD) system and levulinic, gallic, p‐hydroxybenzoic, vanillic and p‐coumaric acids were identified in all studied SHs. The classification of SHs was performed the using PCA and HCA. This study revealed that phenolic compounds and biological properties are effective in classification of SHs according to their geographical origin. The results suggest that studied SHs could be valued as potential agents with versatile bioactivities in oxidative stress‐related disease, microbial infections, inflammation, melanoma, and peptic ulcer.

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Honeys as Possible Sources of Cholinesterase Inhibitors

Cited by 10 publications

References 39 publications

In vitro prospective healthy and nutritional benefits of different Citrus monofloral honeys

In vitro prospective healthy and nutritional benefits of different Citrus monofloral honeys

The Potential Use of Honey as a Neuroprotective Agent for the Management of Neurodegenerative Diseases

HPLC‐DAD Analysis and Versatile Bioactivities of Turkish Sunflower Honeys Using Chemometric Approaches

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