Hookworm control programs and anaemia

Garrow, Stuart C; McCarthy, Justin; Thompson, R. C. A.; Reynoldson, J.A.; Hopkins, R.M.; Musk, Bill

doi:10.5694/j.1326-5377.2001.tb143661.x

Cited by 7 publications

(3 citation statements)

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“…As well as evidence from trials, several operational programmes demonstrate the impact on anaemia of regular treatment, delivered through school health programmes or community-based programmes: in Tanzania, a school-based treatment programme caused a 26% reduction in anaemia and 47% reduction in severe anaemia 15 months post-treatment (Guyatt et al ., 2001); in Western Australia, a six and half year community-based treatment programme resulted in a 38% reduction in anaemia over six and half years (Garrow et al., 2001).…”

Section: Strategies For Controlmentioning

confidence: 99%

Human Hookworm Infection in the 21st Century

Brooker¹,

Bethony²,

Hotez³

2004

Advances in Parasitology

360

329

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The scientific study of human hookworm infection began at the dawn of the twentieth century. In recent years, there have been dramatic improvements in our understanding of many aspects of this globally widespread parasite. This article reviews recent advances in our understanding in the biology, immunology, epidemiology, public health significance and control of hookworm, and to look forward to the study of this important parasite in the 21 st century. Advances in molecular biology has lead to the identification of a variety of new molecules from hookworms, which have importance either in the molecular pathogenesis of hookworm infection or in the host-parasite relationship; some are also promising vaccine targets. At present, relatively little is known about the immune responses to hookworm infection, although it has recently been speculated that hookworm and other helminths may modulate specific immune responses to other pathogens and vaccines. Our epidemiological understanding of hookworm has improved through the development of mathematical models of transmission dynamics, which coupled with decades of field research across mutliple epidemiological settings, have shown that certain population characteristics can now be recognised as common to the epidemiology, population biology and control of hookworm and other helminth species. Recent recognition of the subtle, but significant, impact of hookworm on health and education, together with the simplicity, safety, low cost, and efficacy of chemotherapy has spurred international efforts to control the morbidity due to infection. Large-scale treatment programmes are currently underway, supported by health education and integrated with the provision of improved water and sanitation. There are also efforts underway to develop novel anthelmintic drugs and anti-hookworm vaccines.

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Section: Strategies For Controlmentioning

confidence: 99%

Human Hookworm Infection in the 21st Century

Brooker¹,

Bethony²,

Hotez³

2004

Advances in Parasitology

360

329

View full text Add to dashboard Cite

show abstract

“…In the case of hookworm, mass drug administration (MDA) to primary school children of a single dose of the broad spectrum anthelmintic albendazole on an annual or biannual basis in endemic communities in Northern Australia has proven to be a highly effective public health strategy, resulting in a reduction of the prevalence of both heavy hookworm infection 2 and clinically significant anaemia 4 • Long-term, partially effective anthelmintic treatment may select for drug resistance as was observed in one Kimberley community when pyrantel therapy selected for drug resistance 5 .…”

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confidence: 99%

Control of intestinal helminths in Indigenous communities

McCarthy¹

2009

Microbiol. Aust.

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“…The limited success of attempts to control hookworm in one remote northern Australian Indigenous community of about 350 people has been published in the Journal (with rates of hookworm infection documented in 1992 of up to 93% in children 5–14 years of age) 2 . Recently, our group has published the successful outcome of a 78‐month hookworm infection control program in the same community 5 , 6 . This program's success was due to close liaison with the community, the setting of clear goals, and a commitment to improve environmental infrastructure and local health education, as well as regular targeted, population‐based chemotherapy over a sustained period.…”

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confidence: 99%