“…Flavanol dimers Flavanol dimers linked through a methylene bridge and related unsymmetrical diaromatic methylene have been recently described as natural substances from Glycosmis montana, Agrimonia pilosa or produced by fermentation of cacao liquor (Boyer & Ducrot, 2005) Oligomeric flavanols Flavanols are biologically active molecules that have a wide range of effects and are known as very strong antioxidants that can scavenge various forms of free radicals (Fernandes et al, 2012) Polymers(tannins) Tannins are universally present in plants and represent the fourth most abundant group of secondary metabolites after cellulose, hemicellulose and lignins (Sharma, 2019) Phenolic carboxylic acids Ferulic Acid Ferulic acid (FA) is a type of aromatic acid compound that mainly exists in the cell walls of grass, plants, nuts, etc. During wine making and beer brewing, these phenolic acids can be released from the grape and malt into the juice and wort respectively (Xu et al, 2020) Other polyphenols Prenylflavanoids Prenylflavanoids are present in human fluids (plasma and urine) mainly as glucuronidated and sulphated metabolites (Quifer-Rada et al, 2017) Multifidol glucosides co-, ad-, n-and co-iso-multifidol glucosides, which are phloroglucinol derivatives with prenyl side chains, have been found in hops (Stevens et al, 1998;Chadwick et al, 2004;Stevens et al, 2002;Taylor et al, 2003) Resveratrol Resveratrol is a phytoalexin produced by a variety of plants in response to stress, injury or fungal infection (Jerkovic & Collin, 2007) (Afonso et al, 2021). The αacids isomerized to iso-αacids under high temperature conditions.…”