Hordenine: A Novel Quorum Sensing Inhibitor and Antibiofilm Agent against <i>Pseudomonas aeruginosa</i>

Zhou, Jinwei; Luo, Huai-Zhi; Jiang, Huan; Jian, Ting-Kun; Chen, Ziqian; Jia, Ai‐Qun

doi:10.1021/acs.jafc.7b05035

Cited by 164 publications

(125 citation statements)

References 38 publications

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“…Furthermore, hordenine effectively reduced virulence factors and QS-related gene expression of P. aeruginosa PAO1 [41,42]. It is indicated that the anti-QS potential of hordenine act as a competitive inhibitor for signaling molecules and a novel QS-based agent to defend against foodborne pathogens [41]. Nanoparticles (NPs) like AuNPs was also developed to conjugate with hordenine and hordenine-AuNPs exhibited enhanced anti-biofilm properties on P. aeruginosa PAO1 [43], suggesting nanoparticles-delivered natural compounds could be effectively use in biofilm-based microbial infection.…”

Section: Hordeninementioning

confidence: 96%

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Developing natural products as potential anti-biofilm agents

et al. 2019

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Biofilm is a natural form of bacterial growth ubiquitously in environmental niches. The biofilm formation results in increased resistance to negative environmental influences including resistance to antibiotics and antimicrobial agents. Quorum sensing (QS) is cell-to-cell communication mechanism, which plays an important role in biofilm development and balances the environment when the bacteria density becomes high. Due to the prominent points of biofilms implicated in infectious disease and the spread of multi-drug resistance, it is urgent to discover new antibacterial agents that can regulate biofilm formation and development. Accumulated evidences demonstrated that natural products from plants had antimicrobial and chemo-preventive properties in modulation of biofilm formation in the last two decades. This review will summarize recent studies on the discovery of natural anti-biofilm agents from plants with clear-cut mechanisms or identified molecular addresses, as well as some herbs with unknown mechanisms or unidentified bioactive ingredients. We also focus on the progression of techniques on the extraction and identification of natural anti-biofilm substances. Besides, anti-biofilm therapeutics undergoing clinical trials are discussed. These newly discovered natural anti-biofilm agents are promising candidates which could provide novel strategies for biofilm-associated infections.

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Section: Hordeninementioning

confidence: 96%

Section: Hordeninementioning

confidence: 99%

Developing natural products as potential anti-biofilm agents

et al. 2019

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“…In particular, the production of extracellular virulence factors was partially or completely suppressed in P. aeruginosa cultures grown in the presence of 1 or 10 mM (approximately 2.5 mg/mL) 68 without affecting the growth of the planktonic cultures . Hordenine ( 70 ), a dietary phenolic natural product from sprouting barley, has traditionally been used as a vasoconstrictor and an indirect‐acting adrenergic agent and has also been investigated as a novel QS inhibitor against the formation of pyocyanin at a concentration of 0.5 μM . Zhang and Coenye demonstrated that plant‐derived coumarin ( 71 ) inhibits QS in the P. aeruginosa QSIS2 biosensor strain, reduces protease and pyocyanin production in the range of 1‐3 mM, and suppresses biofilm formation in microtiter plates in different P. aeruginosa strains .…”

Section: Pigments Of Representative Colored Pathogens and Their Inhibmentioning

confidence: 99%

“…151 Hordenine (70), a dietary phenolic natural product from sprouting barley, has traditionally been used as a vasoconstrictor and an indirect-acting adrenergic agent and has also been investigated as a novel QS inhibitor against the formation of pyocyanin at a concentration of 0.5 μM. 152 Zhang and Coenye demonstrated that plant-derived coumarin (71) inhibits QS in the P. aeruginosa QSIS2 biosensor strain, reduces protease and pyocyanin production in the range of 1-3 mM, and suppresses biofilm formation in microtiter plates in different P. aeruginosa strains. 153 In addition to natural products, drug repurposing also plays a critical role in the discovery of antivirulence agents.…”

Section: Pyocyanin Inhibitors From a Natural Product Library And Drmentioning

confidence: 99%

Targeting virulence factors as an antimicrobial approach: Pigment inhibitors

et al. 2019

Medicinal Research Reviews

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The fascinating and dangerous colored pathogens contain unique chemically pigmented molecules, which give varied and efficient assistance as virulence factors to the crucial reproduction and growth of microbes. Therefore, multiple novel strategies and inhibitors have been developed in recent years that target virulence factor pigments. However, despite the importance and significance of this topic, it has not yet been comprehensively reviewed. Moreover, research groups around the world have made successful progress against antibacterial infections by targeting pigment production, including our serial works on the discovery of CrtN inhibitors against staphyloxanthin production in Staphylococcus aureus. On the basis of the previous achievements and recent progress of our group in this field, this article will be the first comprehensive review of pigment inhibitors against colored pathogens, especially S. aureus infections, and this article includes design strategies, representative case studies, advantages, limitations, and perspectives to guide future research.

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“…Antivirulence therapy is an alternative approach to control bacterial infections, targeting the virulence process rather than the viability of pathogens. This leads to less severe infections at a level that can be cleared by the host's immune system (Loo et al, 2016;Silva, Zimmer, Macedo, & Trentin, 2016;Zhou et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Composition, Antivirulence Activity, and Active Property Distribution of the Fruit of Terminalia chebula Retz

Han

et al. 2019

Journal of Food Science

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The fruit of Terminalia chebula Retz., or Tibet Olive, is widely used as a food supplement in China. It possesses some natural antimicrobial properties; however, its chemical composition and antivirulence effects have not been identified. In this work, 29 compounds were identified from the peel of T. chebula fruit by ultra‐high‐performance liquid chromatography‐tandem quadrupole time‐of‐flight mass spectrometry. Both the extract of T. chebula and its phenolic acid, corilagin, showed antivirulent activity against Staphylococcus aureus. Specifically, they inhibited biofilm formation. The half maximal inhibitory concentration was 0.13 and 3.18 µg/mL for the extract and corilagin, respectively, whereas for α‐hemolysin secretion, the respective concentrations were 30 and 10 µg/mL. Its mechanism of action may be due to reducing the transcription of genes related to quorum sensing. These genes included staphylococcal accessory regulator A, intercellular adhesion accessory gene regulator A, and RNAIII. These findings provide evidence that this food supplement could be an effective antivirulent with corilagin as its active ingredient. Practical Application Corilagin from the fruit of Terminalia chebula Retz. may be used as an antibacterial for its antivirulent activity against Staphylococcus aureus

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Hordenine: A Novel Quorum Sensing Inhibitor and Antibiofilm Agent against Pseudomonas aeruginosa

Cited by 164 publications

References 38 publications

Developing natural products as potential anti-biofilm agents

Developing natural products as potential anti-biofilm agents

Targeting virulence factors as an antimicrobial approach: Pigment inhibitors

Composition, Antivirulence Activity, and Active Property Distribution of the Fruit of Terminalia chebula Retz

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