Horizontal Intracorneal Swirling Water Migration Indicative of Corneal Endothelial Function

Kobayashi, Takeshi; Nakao, Saori; Hara, Yuko; Suzuki, Takashi; Hayashi, Yasuhito; Zheng, Xiaodong; Shiraishi, Atsushi; Ohashi, Yuichi

doi:10.1167/iovs.14-14762

Cited by 5 publications

(9 citation statements)

References 16 publications

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“…The significance of peripheral corneal edema has been rarely discussed except for the Brown-McLean syndrome, which is reported to be a clinical condition with peripheral corneal edema developing years after cataract extraction [17][18][19]. We showed experimentally, for the first time the presence of an intracorneal swirling water migration (flow) seen as water flow from the center to the periphery in the horizontal plane of the rabbit cornea (Inoue-Ohashi phenomenon), indicating that this transverse water flow in the cornea strongly contributes to the development of corneal edema [20].…”

Section: Introductionmentioning

confidence: 76%

“…We recently reported for the first time the presence of horizontal water flow in the normal cornea based on rabbit experiments using fluorescein dye as a tracer, as the water flow at a horizontal plane of the cornea [20]. In normal corneas, the water flow moves from the central pooling point to the periphery, expanding the range of the fluorescence, and finally covers the entire cornea.…”

Section: Discussionmentioning

confidence: 99%

“…The experimental methods to estimate the horizontal intracorneal swirling flow in the corneal endothelial dysfunction model using ouabain, a sodium-potassium pump inhibitor, are described in our previous paper [20]. Briefly, ouabain (100 lM) was injected into the anterior chamber.…”

Section: Methods For Rabbit Experimentsmentioning

confidence: 99%

“…The drug was shown previously to suppress the endothelial cellular pump function and horizontal water flow in a dose-dependent manner [20]. We also investigated the extent of the intracorneal water flow and corneal thickness in the peripheral cornea when there was total corneal endothelial dysfunction.…”

Section: Experimental Analysis For Corona Sign Developmentmentioning

confidence: 99%

“…We investigated this experimentally in rabbit corneas by observing horizontal intracorneal swirling flow, the driving force of which depends on the corneal endothelial cellular pump function [20].…”

Section: Experimental Analysis For Corona Sign Developmentmentioning

confidence: 99%

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Corona sign: manifestation of peripheral corneal epithelial edema as a possible marker of the progression of corneal endothelial dysfunction

et al. 2016

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Section: Introductionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Methods For Rabbit Experimentsmentioning

confidence: 99%

Section: Experimental Analysis For Corona Sign Developmentmentioning

confidence: 99%

Section: Experimental Analysis For Corona Sign Developmentmentioning

confidence: 99%

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Corona sign: manifestation of peripheral corneal epithelial edema as a possible marker of the progression of corneal endothelial dysfunction

et al. 2016

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Ocular involvement of oak processionary caterpillar hairs: Clinical outcome up to one year

Leclaire,

Vietmeier,

Treder

et al. 2024

Graefes Arch Clin Exp Ophthalmol

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Purpose To evaluate a consecutive series of patients that presented with ocular findings after contact with the oak processionary caterpillar (OPC) during an epidemic reproduction of the OPC in Germany in 2019 and to assess the 1-year outcome of those eyes with persisting OPC hairs in the cornea. Methods Retrospective analysis of 11 eyes (11 patients) that presented in June/July 2019 with acute ocular symptoms after outdoor activity or caterpillar nest removal. Evaluation of patients charts and slit-lamp images up to one year. Assessment of the incidence of patients with OPC-associated ocular complaints in the subsequent years (2020–2023). Results All patients had conjunctival injection, foreign body sensation, pain, itching and/or burning sensation. In 9/11 eyes, multiple caterpillar hairs could be detected in the superficial and deeper cornea. Hair removal was attempted in 8/9 eyes; in one eye hair removal was impossible due to its deep stromal location (lost-to-follow-up). Entire hair removal was successful in 2/9 eyes, hence, six eyes with persisting hairs within the cornea were followed. Stromal haze developed adjacent to the hairs in all eyes and individual hairs disappeared (n = 4) and/or showed migration within the cornea (n = 3). Until 2023, the number of patients with OPC-associated ocular complaints decreased continuously. Conclusions Ophthalmologists should be aware of the possibility of caterpillar hairs in patients with acute eye symptoms after outdoor acitivities, especially in early summer; the incidence may fluctuate, though. Hair removal is recommended to avoid possible intraocular migration, still residing hairs did not cause any serious long-term complications in our cohort. Key Messages What is known Within the late spring and early summer season, mass reproduction of the oak processionary carterpillar (OPC) can lead to an increased number of patients with OPC-related eye complaints (pain, itching and burning sensation) caused by OPC hairs within a very short period of time. Within that season, people should be (more) actively sensitized to avoid trees with OPC hairs, take precautions and avoid eye rubing when having complaints What is new Complete surgical removal of the hairs can be difficult and is often unsuccessful due to their tiny size and often stromal location most possibly resulting from eye rubbing In the longer-term, residing hairs have shown to develop haze adjacent to the hair, migrate within the cornea or disappear/resolve. Since this may go along with an inflammatory reaction, long-term follow-up and topical steroids may be useful

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Associations Between Regional Environment and Cornea-Related Morphology of the Eye in Young Adults: A Large-Scale Multicenter Cross-Sectional Study

Zhao

Yang

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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Purpose To investigate environmental factors associated with corneal morphologic changes. Methods A cross-sectional study was conducted, which enrolled adults of the Han ethnicity aged 18 to 44 years from 20 cities. The cornea-related morphology was measured using an ocular anterior segment analysis system. The geographic indexes of each city and meteorological indexes of daily city-level data from the past 40 years (1980–2019) were obtained. Correlation analyses at the city level and multilevel model analyses at the eye level were performed. Results In total, 114,067 eyes were used for analysis. In the correlation analyses at the city level, the corneal thickness was positively correlated with the mean values of precipitation (highest r [correlation coefficient]: >0.700), temperature, and relative humidity (RH), as well as the amount of annual variation in precipitation ( r : 0.548 to 0.721), and negatively correlated with the mean daily difference in the temperature (DIF T), duration of sunshine, and variance in RH ( r : −0.694 to 0.495). In contrast, the anterior chamber (AC) volume was negatively correlated with the mean values of precipitation, temperature, RH, and the amount of annual variation in precipitation ( r : −0.672 to −0.448), and positively associated with the mean DIF T ( r = 0.570) and variance in temperature ( r = 0.507). In total 19,988 eyes were analyzed at the eye level. After adjusting for age, precipitation was the major explanatory factor among the environmental factors for the variability in corneal thickness and AC volume. Conclusions Individuals who were raised in warm and wet environments had thicker corneas and smaller AC volumes than those from cold and dry ambient environments. Our findings demonstrate the role of local environmental factors in corneal-related morphology.

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Horizontal Intracorneal Swirling Water Migration Indicative of Corneal Endothelial Function

Cited by 5 publications

References 16 publications

Corona sign: manifestation of peripheral corneal epithelial edema as a possible marker of the progression of corneal endothelial dysfunction

Corona sign: manifestation of peripheral corneal epithelial edema as a possible marker of the progression of corneal endothelial dysfunction

Ocular involvement of oak processionary caterpillar hairs: Clinical outcome up to one year

Associations Between Regional Environment and Cornea-Related Morphology of the Eye in Young Adults: A Large-Scale Multicenter Cross-Sectional Study

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