In this paper. we study properties such as -boundedness, compactness, belonging to Schatten classes and nuclearity, Riesz spectral theory, Fredholmness, ellipticity and Gohberg's lemma, among others, for pseudo-differential operators over the compact group of -adic integers ℤ , where the author in a recent paper introduced a notion of Hörmander classes and pseudo-differential calculus. We extend the results to compact Vilenkin groups which are essentially the same as ℤ . Also we provide a new definition of Hörmander classes for pseudo-differential operators acting on non-compact Vilenkin groups and a explicit formula for the Fredholm spectrum in terms of the associated symbol.