Hormetic effect and mechanism of imidazolium-based ionic liquids on the nematode Caenorhabditis elegans

Zhu, Chunjie; Peng, Yong; Tong, Zhong‐Hua; Lu, Li-Ya; Cui, Yinhua; Yu, Han‐Qing

doi:10.1016/j.chemosphere.2016.05.007

Cited by 24 publications

(10 citation statements)

References 39 publications

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“…Previous work showed that at low concentrations (0.01 mg·L −1 ), the ILs [C 8 C 2 (MIM)][Br], [C 10 C 2 (MIM)][Br], and [C 12 C 2 (MIM)][Br] had a hormetic effect on C. elegans [ 38 ]. The LC 50 values against C. elegans were evaluated for 30 imidazolium-based monocationic ILs possessing several anions, side chains, and substitutions at the C2 of the imidazole [ 38 ]. The LC 50 values for ILs with bromide and chloride decreased when lengthening the side chain, which indicates that longer chains enhance toxicity.…”

Section: Resultsmentioning

confidence: 99%

“…The LC 50 values for ILs with bromide and chloride decreased when lengthening the side chain, which indicates that longer chains enhance toxicity. Additionally, the ILs with bromide anions had greater acute toxicity than the ILs with chloride anions [ 38 ]. Furthermore, Wu et al [ 27 ] showed that imidazolium-based monocationic ILs with bromide anions have dose-dependent toxic effects on C. elegans , with longer alkyl chains resulting in higher toxicity.…”

Section: Resultsmentioning

confidence: 99%

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Antimicrobial and Toxicity Evaluation of Imidazolium-Based Dicationic Ionic Liquids with Dicarboxylate Anions

et al. 2021

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Imidazolium-based dicationic ILs (DILs) presenting antimicrobial activity and relatively low toxicity are highly desirable and are envisioned for use in live tissue to prevent bacterial or fungal infections. In this context, we present here DILs with dicarboxylate anions [Cn(MIM)2[Cn(MIM)2][CO2-(CH2)mCO2], in which n = 4, 6, 8, and 10, and m = 0, 1, 2, 3, 4, and 5. The results showed that DILs with an alkyl chain spacer of ten carbons were active against yeasts and the bacterial strains tested. However, most of the DILs were cytotoxic and toxic at 1 mM. By contrast, DILs with alkyl chains possessing less than ten carbons were active against some specific Candidas and bacteria (mainly S. aureus), and they showed moderate cytotoxicity. The best activity against Gram-positive bacteria was observed for [C4(MIM)2][Pim] toward MRSA. For the DILs described herein, their level of toxicity against C. elegans was lower than that of most of the mono- and dicationic IL analogs with other anions. Our results showed that the presence of carboxylate anions reduces the toxicity of DILs compared to DILs containing halide anions, which is particularly significant to the means of designing biologically active compounds in antimicrobial formulations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Toxicity Evaluation of Imidazolium-Based Dicationic Ionic Liquids with Dicarboxylate Anions

et al. 2021

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“…Radak et al [57] observed that physical exercise could evoke the hormetic curve response by the organism. Zhu et al [85] found that some imidazolium-based ionic liquids exhibited hCRCs when took the lifespan of Caenorhabditis elegans as the toxicity endpoint. Many ionic liquids showed hormesis on different organisms, such as anaerobic Clostridium sp.…”

Section: Discussionmentioning

confidence: 99%

The weak magnetic field (WMF) enhances the stimulation of polymyxin B sulfate (POL) on Vibrio qinghaiensis sp.-Q67

Wang

et al. 2020

Environ Sci Eur

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Background: The weak magnetic field (WMF) can enhance the ability to remove target pollutants in wastewater, which drives us to consider whether WMF could give rise to the hormesis or not. In our previous study, it was found that polymyxin B sulfate (POL) can induce weak hormesis on Vibrio qinghaiensis sp.-Q67 (Q67). To this end, we set up four different WMF treatments during Q67 culture and POL exposure process, having no WMF in all cases (NW), adding WMF all the time (AW), exerting WMF only during the bacterial culture (BW), and exerting WMF only in POL exposure period (EW). Results: It was shown that the concentration-response curves (CRCs) of POL in four WMF treatments at the exposure times of 6, 9, and 12 h are non-monotonic hormetic curves where the maximum stimulative effects (E min) of POL in BW and EW are obviously larger than those in AW and NW. The maximum E min is 26.8% occurring in EW and 20.7% in BW at 6 h, while the max E min is 14.6% in NW at 9 h, it means that stimulations of POL in BW and EW are earlier and stronger than those in NW. These findings first indicated that WMF can enhance the hormesis of POL. Conclusions: This study showed that WMF as a key factor may influence the maximum stimulation effect of hormesis. The characteristic of biphasic (hormetic effect) challenges the traditional classical threshold model that is close to chemical risk assessment. But the mechanism of hormesis even now is inconclusive. WMF as a novelty and neglected factor has the potential to support the further development of hormesis mechanism.

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“…Components of extracellular polymeric substances (EPS), including extracellular proteins (PN), polysaccharides (PS), and humic-like substances (HS) were quantified, and functional groups in EPS were examined by Fourier transform infrared (FTIR) spectrum (Nicolet 6700, Thermo, USA). The level of harmful substance produced during V(V) reduction, that is, intracellular reactive oxygen species (ROS) was measured according to previous method . The cell membrane integrity was assayed by measuring the LDH release .…”

Section: Methodsmentioning

confidence: 99%

“…The level of harmful substance produced during V(V) reduction, that is, intracellular reactive oxygen species (ROS) was measured according to previous method. 28 The cell membrane integrity was assayed by measuring the LDH release. 29 The content of energy substance, that is, ■ RESULTS AND DISCUSSION V(V) Bio-Reduction Performance.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Novel Pathway for Vanadium(V) Bio-Detoxification by Gram-Positive Lactococcus raffinolactis

Zhang

Fei

et al. 2021

Environ. Sci. Technol.

129

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Whereas prospects of bioremediation for a vanadium(V) [V(V)]-contaminated environment are widely recognized, reported functional species are extremely limited, with the vast majority of Gram-negative bacteria in Proteobacteria. Herein, the effectiveness of V(V) reduction is proved for the first time by Lactococcus raffinolactis, a Gram-positive bacterium in Firmicutes. The V(V) removal efficiency was 86.5 ± 2.17% during 10-d operation, with an average removal rate of 4.32 ± 0.28 mg/L·d in a citrate-fed system correspondingly. V(V) was bio-reduced to insoluble vanadium(IV) and distributed both inside and outside the cells. Nitrite reductase encoded by gene nirS mainly catalyzed intracellular V(V) reduction, revealing a previously unrecognized pathway. Oxidative stress induced by reactive oxygen species from dissimilatory V(V) reduction was alleviated through strengthened superoxide dismutase and catalase activities. Extracellular polymeric substances with chemically reactive hydroxyl (−OH) and carboxyl (−COO–) groups also contributed to V(V) binding and reduction as well as ROS scavenging. This study can improve the understanding of Gram-positive bacteria for V(V) bio-detoxification and offer microbial resources for bioremediation of a V(V)-polluted environment.

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Hormetic effect and mechanism of imidazolium-based ionic liquids on the nematode Caenorhabditis elegans

Cited by 24 publications

References 39 publications

Antimicrobial and Toxicity Evaluation of Imidazolium-Based Dicationic Ionic Liquids with Dicarboxylate Anions

Antimicrobial and Toxicity Evaluation of Imidazolium-Based Dicationic Ionic Liquids with Dicarboxylate Anions

The weak magnetic field (WMF) enhances the stimulation of polymyxin B sulfate (POL) on Vibrio qinghaiensis sp.-Q67

Novel Pathway for Vanadium(V) Bio-Detoxification by Gram-Positive Lactococcus raffinolactis

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