Hormonal Activity of Testes in Aged Rats with Leydig Cell Hyperplasia Histochemical Investigation of Some Hydroxysteroid Dehydrogenases

Lehmann, Hugo; L, Lützen; Deutsch, H.

doi:10.1016/s0005-8165(75)80143-0

Cited by 3 publications

(4 citation statements)

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“…Western blot analyses revealed age-related changes in CYP11A1, 3-HSD and CYP17 that were consistent with enzymatic activity analyses [188,190,192]. In contrast, no changes in testicular 3-HSD were noted by Lehmann et al [176].…”

Section: Experimental Animalssupporting

confidence: 75%

“…Tsitouras et al, [184] reported that in vivo pretreatment with, but not in vitro exposure to, hCG reverses the testosterone secretory defect of Leydig cells from old rats. Overall, these changes appear not to be a function of gonadotropin receptor activity, or cAMP formation [162,177,182,183,185,186] or a defect in the steroid hormone synthesizing enzymes [176,186] although there are some exceptions to this. For example, Pirke et al, [162] reported significant loss of hCG binding to whole testicular membranes of old rats, while Tsitouras et al, [182] observed only a modest decrease in hCG binding to membrane preparations from the purified Leydig cells.…”

Section: Experimental Animalsmentioning

confidence: 94%

“…In contrast, occurrence of Leydig cell hyperplasia as a consequence of aging has also been reported in stallions [179] and humans [141]. Other studies suggest that Leydig cells undergo atrophic changes in size [168,169,176,180] and organelle content [178] with aging. Bethea and Walker [181] provided evidence showing that aging leads to decreased Leydig cell mass, at least in testis of Fischer rats.…”

Section: Experimental Animalsmentioning

confidence: 99%

“…A number of studies indicate that the number of Leydig cells per testis is either unchanged or increased [162,[176][177][178]. In contrast, occurrence of Leydig cell hyperplasia as a consequence of aging has also been reported in stallions [179] and humans [141].…”

Section: Experimental Animalsmentioning

confidence: 99%

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Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Steroid hormones are lipophilic, low-molecular weight organic compounds all of which are derived from cholesterol. They are primarily synthesized by steroidogenic glands such as gonads (ovary and testis), the adrenal gland and, during pregnancy, by the placental trophoblasts. Limited steroid synthesis also takes place in the brain. Steroid hormones are crucial for the proper functioning of the body. They mediate a wide variety of vital physiological functions, ranging from maintaining normal reproductive function and secondary sexual characteristics, to regulating virtually every metabolic process in the body. Like many age-related endocrine disorders, aging also progressively impacts the tissue-specific synthesis and secretion of steroid hormones. The goal of this review is to summarize the effects of aging on steroid hormone synthesis and secretion by the adrenal gland and gonads of both human and experimental animal models, to describe the potential involvement of excessive oxidative stress in mediating age-related alterations in steroidogenesis, and to discuss the possible underlying mechanisms involved.

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Section: Experimental Animalssupporting

confidence: 75%

Section: Experimental Animalsmentioning

confidence: 94%

Section: Experimental Animalsmentioning

confidence: 99%

Section: Experimental Animalsmentioning

confidence: 99%

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Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Neoplastic Diseases

Altman¹,

Goodman²

1979

The Laboratory Rat

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Testosterone Secretion in the Rat in Response to Chorionic Gonadotrophin: Alterations with Age

Danner

Roth

1978

Endocrinology

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It has been reported by others that both prevailing blood concentrations of testosterone and Leydig cell response to gonadotrophin (up to 1 h after injection) are reduced in the aged male rat. Although resting levels of plasma testosterone in our aged (24-26 months old) Sprague-Dawley rat are also depressed compared with young (3-4 months) or mature (12 months) animals of the same strain, subcutaneous injection with human chorionic gonadotrophin for 3 days restores secretory function, producing testosterone levels indistinguishable from those of similarly stimulated younger rats. In short term experiments, old rats did show a diminished testesterone secretory response to human chorionic gonadotrophin 1 h after a single intravenous injection, consistent with previous reports, but restoration of normal stimulated levels was observed by 2 h, and persisted up to 24 h. These findings differ from the demonstrated intrinsic testicular hyporesponsiveness to gonadotrophin of aged men, and probably represented a state of chronic understimulation of the aged rat Leydig cells, due to low prevailing levels of LH.

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Hormonal Activity of Testes in Aged Rats with Leydig Cell Hyperplasia Histochemical Investigation of Some Hydroxysteroid Dehydrogenases

Cited by 3 publications

References 6 publications

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Neoplastic Diseases

Testosterone Secretion in the Rat in Response to Chorionic Gonadotrophin: Alterations with Age

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