Hormonal and local regulation of uterine activity during parturition: part I — The oxytocin system

Peptide Signaling in Human Placenta and Membranes: Autocrine, Paracrine, and Endocrine Mechanisms*

“…Control of contractility. The major regulators of uterine contractility are OT and PGs (22,368,369). The initiation of term and preterm labor has been related to an increased myometrial responsiveness to OT near or at the time of parturition: synthetic OT is at least 8-fold more effective in inducing uterine contractions in pregnant women at term than in early gestation (23,370): this effect can be reduced using OT antagonists (368).…”

“…The major regulators of uterine contractility are OT and PGs (22,368,369). The initiation of term and preterm labor has been related to an increased myometrial responsiveness to OT near or at the time of parturition: synthetic OT is at least 8-fold more effective in inducing uterine contractions in pregnant women at term than in early gestation (23,370): this effect can be reduced using OT antagonists (368). The increase in the sensitivity of the uterus to OT with advancing gestation and in termpregnant women is mediated by a specific increase in the density of OT receptor and increased uterine sensitivity to OT (368).…”

Μηχανισμοί Συσταλτικής Ανταποκρισιμότητας Του Μυομητρίου Στη Δράση Της Προγεστερόνης Και Της Ενδοθηλίνης

“…Στα ινοµυώµατα µόνο ο υποτύπος ΕΤΑ εντοπίζεται (Breuiller-Fouche et al 1997 (Maggi et al 1994, Heluy et al 1995.…”

“…Σε µήτρα εµµηνοπαυσιακών γυναικών δεν παρατηρήθηκαν σηµαντικές διαφορές στις συγκεντρώσεις ΕΤΑ-ΕΤΒ σε σύγκριση µε αυτές που παρατηρούνται στο τέλος της κύησης και τον τοκετό (Maggi et al 1994). 1992, Cameron et al 1993, Ohbuchi et al 1995.…”

“…Στο µυοµήτριο προεµµηνοπαυσιακών και εµµηνοπαυσιακών γυναικών παρατηρήθηκε ελάχιστη ανοσολογική αντίδραση (Maggi et al 1994, Ohbuchi et al 1995.…”