Hormonal and Metabolic Responses to a Single Bout of Resistance Exercise in Prader-Willi Syndrome

Rubin, Daniela A.; Clark, Susan J.; Haqq, Andrea M.; Castner, Diobel M.; Ng, Jason; Judelson, Daniel A.

doi:10.1159/000454805

Cited by 5 publications

(14 citation statements)

References 27 publications

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“…The findings on hormonal responses to exercise are inconsistent across studies; however, differences between study protocols performed and the limited sample sizes could have contributed to these discrepancies . The two studies that analysed the hormonal response to exercise were conducted in children and adolescents .…”

Section: Resultsmentioning

confidence: 99%

“…A total of 483 studies were identified, of which 447 did not meet the inclusion criteria. Twenty-two studies, 10,15,16,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] whose details are summarized in Tables 2 and 3 Mullins (1987)…”

Section: Participants' Characteristicsmentioning

confidence: 99%

“…Ten studies 10,15,16,[22][23][24][25] reported the acute effects (either physiological response or physical performance) of exercise in patients with PWS using the following types of exercise tests: cycle ergometer, 16,22,23 lower-body strength, 10,24,33 treadmill along with upper-body strength and flexibility, 15 only treadmill, 25,34 or the Bruininks-Oseretsky test to analyse motor proficiency. 35 Eight out of ten studies were carried out in children and/or adolescents, 16,[22][23][24][25] with the remainder of studies conducted in adults. 10,15 Five studies analysed cardiorespiratory responses.…”

Section: Acute Response To Exercisementioning

confidence: 99%

“…35 The findings on hormonal responses to exercise are inconsistent across studies; however, differences between study protocols performed and the limited sample sizes could have contributed to these discrepancies. 23,24 The two studies that analysed the hormonal response to exercise were conducted in children and adolescents. 23,24 One study found no change in GH and a lower increase in epinephrine and norepinephrine concentrations after endurance exercise in children with PWS compared to lean and obese controls, but similar levels of insulin, glucose, lactate, free fatty acids and glycerol.…”

Section: Ta B L E 3 (Continued)mentioning

confidence: 99%

“…23,24 The two studies that analysed the hormonal response to exercise were conducted in children and adolescents. 23,24 One study found no change in GH and a lower increase in epinephrine and norepinephrine concentrations after endurance exercise in children with PWS compared to lean and obese controls, but similar levels of insulin, glucose, lactate, free fatty acids and glycerol. 23 In contrast, similar catecholamine, glucagon and insulin responses but higher glycerol and ketone levels were observed after resistance exercise involving the lower body in children with PWS compared to lean or obese age-matched controls.…”

Section: Ta B L E 3 (Continued)mentioning

confidence: 99%

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Physical exercise and Prader‐Willi syndrome: A systematic review

Morales

Valenzuela²,

Pareja‐Galeano

et al. 2019

Clinical Endocrinology

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Summary Objective The aim of this systematic review was to summarize evidence on the acute responses of individuals with Prader‐Willi syndrome (PWS) to physical exercise, and on the effectiveness of long‐term exercise interventions to improve the clinical manifestations of this syndrome. Design/methods Relevant articles were identified in the electronic databases PubMed, Medline, CINAHL and SPORTDiscus (from inception to December 2018). Twenty‐two studies including a total of 356 patients with PWS met all inclusion criteria and were included in the review. Results Patients with PWS present with a decreased physical performance and impaired cardiorespiratory (maximal oxygen consumption, heart rate recovery after exercise) and hormonal (growth hormone release) responses to exercise. Most long‐term exercise interventions have proven to decrease body mass while improving physical performance. Some benefits have also been reported in biochemical (glucose homeostasis, lipid profile) and biomechanical (gait pattern) variables, although there is controversy regarding the effects on body composition. No exercise‐related adverse events have been reported in patients with PWS. Conclusion Physical exercise seems to be safe and effective for improving several phenotypes in PWS, notably physical fitness. However, further research is needed to confirm these results and especially to corroborate whether exercise per se or combined with dietary intervention is an effective coadjuvant treatment for reducing body mass in these patients.

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Section: Resultsmentioning

confidence: 99%

Section: Participants' Characteristicsmentioning

confidence: 99%

Section: Acute Response To Exercisementioning

confidence: 99%

Section: Ta B L E 3 (Continued)mentioning

confidence: 99%

Section: Ta B L E 3 (Continued)mentioning

confidence: 99%

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Physical exercise and Prader‐Willi syndrome: A systematic review

Morales

Valenzuela²,

Pareja‐Galeano

et al. 2019

Clinical Endocrinology

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Metabolic responses to walking in children with Prader‐Willi syndrome on growth hormone replacement therapy

Hyde

Chavoya

Silveira

et al. 2018

American J of Med Genetics Pt A

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Myokine levels after resistance exercise in young adults with Prader–Willi syndrome (PWS)

Hirsch

Gross‐Tsur

Sabag

et al. 2019

American J of Med Genetics Pt A

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Individuals with PWS require marked caloric restriction and daily exercise to prevent morbid obesity. Lower energy expenditure, hypotonia, decreased muscle mass, and cognitive impairment make exercise challenging for this population. Exercise guidelines include resistance training as an important component. Myokine responses to resistance exercise may mediate beneficial metabolic effects. We aimed to determine if young PWS adults can perform a resistance exercise program and to measure myokine responses in PWS versus age-and BMI-matched controls. Each group included 11 participants (7M/4F). Ages and BMI for PWS and controls were 30.7 ± 4.6 versus 30.1 ± 4.3 years and 28.3 ± 4.3 versus 28.2 ± 4.2 kg/m 2 , respectively.Glucose, creatine kinase (CK), lactate, and myokines were measured before, after, 30, and 60 min after completing eight resistance exercises. Myokines were assayed using a multiplex myokine panel (Merck Millipore). CK was lower in PWS versus controls (62 ± 16 vs.322 ± 100 U/L, p < .04). Peak lactate was 3.7 ± 0.7 in PWS versus 7.3 ± 0.7 mmol/Lin controls (p < .001). The increase in interleukin-6 was similar in PWS and controls (41 ± 16% and 35 ± 10%, respectively). Pre-and post-exercise levels of the six myokines assayed showed no consistent differences between the PWS and control participants. PWS young adults are capable of performing resistance/strength-building exercise. The lower CK and peak lactate levels in PWS may reflect decreased muscle mass in this population. Further studies are needed to determine optimal exercise regimens and assess the role of myokines incontributing to the metabolic phenotype of PWS. K E Y W O R D Sbrain-derived neurotropic factor (BDNF), exercise, interleukin-6 (IL-6), lactate, obesity

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Hormonal and Metabolic Responses to a Single Bout of Resistance Exercise in Prader-Willi Syndrome

Cited by 5 publications

References 27 publications

Physical exercise and Prader‐Willi syndrome: A systematic review

Physical exercise and Prader‐Willi syndrome: A systematic review

Metabolic responses to walking in children with Prader‐Willi syndrome on growth hormone replacement therapy

Myokine levels after resistance exercise in young adults with Prader–Willi syndrome (PWS)

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