Hormonal contraceptives and breast cancer: Clinical data

Zolfaroli, Irene; Tarı́n, Juan J.; Cano, Antonio

doi:10.1016/j.ejogrb.2018.03.058

Cited by 17 publications

(12 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Obviously, the effects of the hormonal changes on a woman’s body during reproductive age can increase the risk of breast cancer, and the effects of synthetic hormones are no exception. Several studies have found a reverse effect of contraceptives on breast tissue [33–35]. The combined estrogen in hormonal contraception has been identified in earlier studies as a major cause for breast cancer [33, 34].…”

Section: Discussionmentioning

confidence: 99%

Determinants of breast cancer in Saudi women from Makkah region: a case-control study (breast cancer risk factors among Saudi women)

et al. 2019

View full text Add to dashboard Cite

BackgroundThere are various factors that play a major role in influencing the overall health conditions of women diagnosed with breast cancer. The population of women in Makkah region are diverse, therefore it is significant to highlight the possible determinants of breast cancer in this population. This is a case-control study that assessed determinants of breast cancer including socioeconomic factors, health-related characteristics, menstrual histories and breastfeeding among postmenopausal women in Makkah region in Saudi Arabia.MethodsA total of 432 female participants (214 cases and 218 controls) were recruited for this study. A validated questionnaire was completed by trained dietitians at King Abdullah Medical City Hospital in the Makkah region of Saudi Arabia.ResultsResults displayed that determinants of breast cancer were associated significantly (P < 0.05) with unemployment, large family size, lack of knowledge and awareness about breast cancer, obesity, sedentary lifestyle, smoking, starting menarche at an early age, as well as hormonal and non-hormonal contraceptive use. There was no effect of diabetes, hypertension, hyperlipidemia, and duration of breastfeeding on the incidence of breast cancer.ConclusionIn summary, the results of this study accentuate the possible effect of socioeconomic factors, health-related characteristics and menstrual history on the incidence of breast cancer in postmenopausal women in the Makkah region. Education programs should be applied to increase breast cancer awareness and possibly decrease its incidence.

show abstract

Section: Discussionmentioning

confidence: 99%

Determinants of breast cancer in Saudi women from Makkah region: a case-control study (breast cancer risk factors among Saudi women)

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Researchers, regarding the association of medroxyprogesterone acetate with breast cancer, have stated that this correlation may be due to the diagnosis of mammary tumors or the growth of existing mammary tumors 66. An increased risk of developing breast cancer diminishes 5–10 years after the discontinuation of hormonal contraceptives 67…”

Section: Risk Factorsmentioning

confidence: 99%

<p>Epidemiological characteristics of and risk factors for breast cancer in the world</p>

Momenimovahed¹,

Salehiniya²

2019

BCTT

685

471

View full text Add to dashboard Cite

Aim Breast cancer is the most common cancer among women and one of the most important causes of death among them. This review aimed to investigate the incidence and mortality rates of breast cancer and to identify the risk factors for breast cancer in the world. Materials and methods A search was performed in PubMed, Web of Science, and Scopus databases without any time restrictions. The search keywords included the following terms: breast cancer, risk factors, incidence, and mortality and a combination of these terms. Studies published in English that referred to various aspects of breast cancer including epidemiology and risk factors were included in the study. Overall, 142 articles published in English were included in the study. Results Based on the published studies, the incidence rate of breast cancer varies greatly with race and ethnicity and is higher in developed countries. Results of this study show that mortality rate of breast cancer is higher in less developed regions. The findings of this study demonstrated that various risk factors including demographic, reproductive, hormonal, hereditary, breast related, and lifestyle contribute to the incidence of breast cancer. Conclusion The results of this study indicated that incidence and mortality rates of breast cancer is rising, so design and implementation of screening programs and the control of risk factors seem essential.

show abstract

“…6 These findings have also been observed for progestogen-only treatments in hormonal contraceptive users. 12 The molecular mechanism underlying the proliferative effect of progestogens seen in breast but not endometrium has remained elusive for several years.…”

Section: Progestogens and The Breastmentioning

confidence: 99%

The RANKL/RANK system in female reproductive organ tumors: A preclinical and clinical overview

Monzó-Miralles¹,

Martín-González²,

Smith-Ballester³

et al. 2021

Adv Clin Exp Med

Self Cite

View full text Add to dashboard Cite

The receptor activator of nuclear factor-κB (RANK) and its ligand RANKL are members of the tumor necrosis factor (TNF) super-family of cytokines with a role in progestogen-associated malignancies in breast. Basic and clinical data support the participation of the cytokine pathway in metastatic disease and as poor prognosis markers. The value of RANK/RANKL as prognostic indicators in endometrial and ovarian tumors, as well as the data suggesting a potential role of RANK/RANKL in hormone dependent tumorigenesis in the endometrium, have been described. The D-CARE study could not confirm benefit in the modulation of RANKL in breast cancer.

show abstract

Hormonal contraceptives and breast cancer: Clinical data

Cited by 17 publications

References 42 publications

Determinants of breast cancer in Saudi women from Makkah region: a case-control study (breast cancer risk factors among Saudi women)

Determinants of breast cancer in Saudi women from Makkah region: a case-control study (breast cancer risk factors among Saudi women)

<p>Epidemiological characteristics of and risk factors for breast cancer in the world</p>

The RANKL/RANK system in female reproductive organ tumors: A preclinical and clinical overview

Contact Info

Product

Resources

About