Hormonal Control of Gastrointestinal Motility

Dinoso, Vicente P.; Murthy, Shubha

doi:10.1159/000171095

Cited by 5 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These alcohol-asso ciated effects are either due to a direct local alcohol action or mediated by neural stimuli and/or gastrointestinal hormones. Gastroin testinal hormones involved in the regulation of intestinal motility and cellular regenera tion include gastrin, enteroglucagon (EG), pancreatic glucagon (PG) and possibly pep tide YY (PYY) [4][5][6][7][8][9][10][11][12], Since there are no data yet available on the effect of acute or chronic alcohol ingestion on these gastroin testinal hormones, we used a standardized alcohol rat model [ 13] to study plasma con centrations and to quantify mucosal endo crine cell numbers. …”

mentioning

confidence: 99%

Effects of Acute and Chronic Ethanol Administration on the Gastrointestinal Hormones Gastrin, Enteroglucagon, Pancreatic Glucagon and Peptide YY in the Rat

Simanowski¹,

Hubalek²,

Ghatei³

et al. 1989

Digestion

View full text Add to dashboard Cite

The effect of acute and chronic ethanol administration on the gastrointestinal hormones gastrin, enteroglucagon (EG), pancreatic glucagon (PG) and peptide YY (PYY) was studied in the rat alcohol model. Plasma levels of gastrin and PYY were not significantly changed under chronic and/or acute alcohol, while PG was stimulated by acute intraperitoneal ethanol injections in control animals as well as in chronically ethanol-fed rats (8 ± 1 vs. 28 ± 6 pmol/l, p ≤ 0.05, and 7 ± 1 vs. 21 ± 4 pmol/l, p ≤ 0.05). EG levels were significantly raised after chronic ethanol feeding (45 ± 5 vs. 73 ± 8 pmol/l, p ≤ 0.01) and even further elevated if an acute dose of alcohol was given to chronically ethanol-fed rats (73 ± 8 vs. 168 ± 29 pmol/l, p ≤ 0.05). The immunohistologically evaluated numbers of the respective hormone-producing cells were not significantly changed by alcohol feeding. The ethanol-dependent elevations of EG and PG may contribute, at least in part, to the intestinal hyperregeneration, motility disturbances and altered glucose metabolism observed after alcohol consumption.

show abstract

mentioning

confidence: 99%

Effects of Acute and Chronic Ethanol Administration on the Gastrointestinal Hormones Gastrin, Enteroglucagon, Pancreatic Glucagon and Peptide YY in the Rat

Simanowski¹,

Hubalek²,

Ghatei³

et al. 1989

Digestion

View full text Add to dashboard Cite

show abstract

Der gastrektomierte Patient

Faß¹

1998

Pouch

View full text Add to dashboard Cite

Effect of bombesin and substance P on the smooth muscle of the chicken crop

Denac

Scharrer

1988

Vet Res Commun

View full text Add to dashboard Cite

The effect of bombesin and of substance P was investigated in smooth muscle strips of the chicken crop. Bombesin in picomolar concentration (0.1 x 10(-12) - 5 X 10(-12) mol/l) caused a concentration-related contraction of the muscle strips. Substance P in nanomolar concentration (0.1 x 10(-9) - 10 x 10(-9) mol/l) was effective in the same manner. Tetrodotoxin (2 x 10(-7) mol/l) did not influence the contraction responses to either bombesin or substance P. The excitatory effect of bombesin and of substance P did not follow activation of cholinergic receptors since their effect on the crop smooth muscle was not antagonized by atropine (10(-4) mol/l) or by hexamethonium (10(-4) mol/l). Strips stored for 24 hours in the Tyrode's solution at 4 degrees C without a supply of oxygen maintained their full sensitivity to bombesin and to substance P. These results are consistent with a direct action of bombesin and substance P on the crop smooth muscle.

show abstract

Hormonal Control of Gastrointestinal Motility

Cited by 5 publications

References 14 publications

Effects of Acute and Chronic Ethanol Administration on the Gastrointestinal Hormones Gastrin, Enteroglucagon, Pancreatic Glucagon and Peptide YY in the Rat

Effects of Acute and Chronic Ethanol Administration on the Gastrointestinal Hormones Gastrin, Enteroglucagon, Pancreatic Glucagon and Peptide YY in the Rat

Der gastrektomierte Patient

Effect of bombesin and substance P on the smooth muscle of the chicken crop

Contact Info

Product

Resources

About