1972
DOI: 10.1007/978-1-4684-7547-0_6
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Hormonal Control of Lipolysis in Adipose Tissue

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Cited by 15 publications
(3 citation statements)
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“…Activated Gs-coupled hormone receptors are known to stimulate intracellular cAMP accumulation, leading to the activation of a cAMP-dependent protein kinase, PKA. Hormone-sensitive lipase (HSL) and perilipin are phosphorylated by PKA, resulting in catalysis in the breakdown of triglycerides and diglycerides , . Experiments have revealed that, in vitro , activated ERK1/2 causes HSL phosphorylation at Ser600 , producing a hydrolytic activity similar to that observed when HSL is phosphorylated by PKA .…”
Section: Discussionmentioning
confidence: 99%
“…Activated Gs-coupled hormone receptors are known to stimulate intracellular cAMP accumulation, leading to the activation of a cAMP-dependent protein kinase, PKA. Hormone-sensitive lipase (HSL) and perilipin are phosphorylated by PKA, resulting in catalysis in the breakdown of triglycerides and diglycerides , . Experiments have revealed that, in vitro , activated ERK1/2 causes HSL phosphorylation at Ser600 , producing a hydrolytic activity similar to that observed when HSL is phosphorylated by PKA .…”
Section: Discussionmentioning
confidence: 99%
“…The above-mentioned gene duplications entail the exploitation of pre-existing physiologic traits that would permit the rise of endothermy/homeothermy to meet the environmental stresses of the water-land transition along antecedent pathways from which constructive physiological linkages could arise [25]. In the scenario cited above, the advantage of amplified catecholamine activity to alleviate the constraint of air-breathing would have secondarily caused the lipolytic secretion of fatty acids from peripheral fat cells [51]. In consequence, increasing metabolism and body temperature would be expected [52,53].…”
Section: Evolution Of Endothermy/homeothermy As Evidence For the Effementioning
confidence: 99%
“…The now active PKA can then phosphorylate and stimulate the hormone sensitive lipase (HSL) enzyme. Subsequently, HSL hydrolyses the ester bonds in tri-and diglycerides in the perilipins of the adipocytes in the white adipose tissue to free fatty acids, which are then secreted into the blood [318][319][320][321][322].…”
Section: Atp + Acetate + Co-enzymea $ Amp + Pyrophosphate + Acetyl-coamentioning
confidence: 99%