Hormonal Evaluation in Females Having Melasma

Abstract

BACKGROUND:Melasma is a commonly acquired hyperpigmentation which present as irregular, light to dark brown macules on sun exposed skin due to various etiological factors including hormonal imbalance. AIM: To assist the level of various hormones and study the clinical and hormonal correlation in patients of melasma. METHODS: 50 female patients of melasma between age group 18-50 with equal number of age matched females with no signs of melasma, hirsutism and any other endocrinal abnormality, were enrolled. They were examined by woods' lamp to see the type of melasma whether epidermal, dermal or mixed. 10 ml of venous blood sample was drawn after overnight fasting on 3 rd -5 th day of the menstrual cycle in mid follicular phase for the assessment of LH, FSH, Prolactin, Estradiol and Progesterone by chemiluminescence method. RESULT: Out of 50 patients, 8 patients had deranged level of LH, 7 patients had deranged level of FSH, 14 patients had deranged prolactein, 18 patients had deranged estradiol and 6 patients had deranged level of progesterone. 70% patients were married and belong to age group of 31-40 years. 18 % patients has onset of melasma during pregnancy while 52% patients after the delivery. CONCLUSIONS: LH, estradiol and progesterone are found to be contributory factors in development of melasma.

The Effects of Acupuncture Combined with Auricular Acupressure in the Treatment of Chloasma

“…Along with other etiologic factors such as sun exposure and pregnancy drugs, hormones such as estradiol and progesterone have been found to be the major contributing factors in the development of chloasma [ 46 ]. The occurrence of chloasma with estrogen- and progesterone-containing oral contraceptive pills has been reported [ 36 ].…”

Follicular‐Stimulating Hormone, Luteinizing Hormone, and Prolactin Serum Level in Patients with Oral Lichen Planus in Comparison to Healthy Population

“…OLP is more prevalent in premenopausal women which is associated with gonadotropin estrogen and progesterone fluctuations [31]. FSH and LH increment in menopausal status is due to feedback cycle of estrogen and progesterone reduction [32,33]. These hormonal changes may participate in etiopathogenesis of OLP.…”