Hormonal imbalance and disturbances in carbohydrate metabolism associated with chronic feeding of high sucrose low magnesium diet in weanling male wistar rats

Abstract

This study was designed to determine chronic effect of high sucrose low magnesium (HSLM) diet in weanling rats on plasma thyroid profile, catecholamines and activities of key hepatic glycolytic, and gluconeogenic enzymes. Compared to control diet fed group, significantly elevated levels of plasma triiodothyronine, tetraiodothyronine, catecholamines (epinephrine, norepinephrine, and dopamine) and activity of hepatic glycolytic (hexokinase and glucokinase), and gluconeogenic (glucose-6-phosphatase) enzymes were observed in high sucrose and low magnesium fed groups. However, HSLM diet had an additive effect on all these three parameters. The study thus, assumes significance as it shows that hormonal imbalance and disorders in carbohydrate metabolism at an early stage of development can be due to dietary modification or due to deficiency of key element magnesium.

Aberrant expression of miRNA profiles in high-fat and high-sucrose fed rats

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Identification of molecular markers related to human alveolar bone cells and pathway analysis in diabetic patients

“…Diabetes is known to cause disorders in the glucose metabolism, impacting a series of metabolic processes, and eventually leading to multiple metabolic disorders (Garg et al, 2014;Lopez et al, 2014). The pentose phosphate pathway is a major pathway for glucose metabolism.…”

Western diet induces endogen oxidative deoxyribonucleic acid damage and infl ammation in Wistar rats

“…The control group only received standard feed and tap water. The rats in the remaining three groups were given one of the following diets: a high-fat diet in which the total energy (kcal35%) was supplied by suet [23], a high-sucrose diet in which 69% of carbohydrate-derived energy content was provided by sucrose [24], and the Western diet, which was the combination of the high-fat and high-sucrose diets. For acclimatization, the animals were fed with high-fat or high-sucrose feed mixed with standard feed for three days.…”