Hormonal Profiles and Prevalence of Polycystic Ovary Syndrome in Women with Acne

Timpatanapong, P; Rojanasakul, A

doi:10.1111/j.1346-8138.1997.tb02778.x

Cited by 80 publications

(69 citation statements)

References 19 publications

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“…20 Timpatanapong P et al studied hormonal profiles and prevalence of polycystic ovary syndrome in women with acne in1997 and documented frequent association of acne in women with PCOS. 21 83.75% of patients in this study had acne which is similar to the results obtained by Timpatanapong P et al 21 85% patients in the present test group had lost weight at the end of 6 months while only 55% in the control group had lost weight in 6 months. Weight loss of more than 5% was considered significant.…”

Section: Discussionsupporting

confidence: 88%

PCOS in adolescence: effect of metformin on menstrual irregularities

Sontakke

2017

Int J Reprod Contracept Obstet Gynecol

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Background: PCOS is an endocrine disorder affecting women across lifespan, initially a disease of the females in the child bearing age group, nowadays maximum adolescent females also present with PCOS. Adolescence PCOS is a heterogenous endocrine disorder diagnosed in 5% to 10% of adolescent girls and is one of the major causes of adolescent hyperandrogenism and menstrual irregularity. Thus, this study was carried out to study the effect of Metformin on adolescent patients with PCOS on Weight reduction and Regularization of Menstrual cycle. Secondary objective is to study the occurrences of various manifestations in patients with PCOS.Methods: Patients aged 10-20 years diagnosed PCOS attending the outpatient department of OBGY over a period of two years were included in the study. Out of 100 patients, 20 patients were excluded because of other causes of anovulation viz thyroid abnormalities, prolactin level abnormalities and patients who did not turn up for follow up. Study was done on 80 patients of PCOS. Patients were divided into two groups A and B. Group A (n=40) received 500 mgs Metformin and Group B (n=40) received placebo. Results were analysed using statistical package of social sciences (SPSS) 21.0. Statistical significance was set at p ≤0.05.Results: In the present study Irregular cycle was the commonest occurring menstrual irregularity. Menstrual Cycle was regularised in 95% of the study group while only 35% of the control group. 85% patients in the present test group had lost weight at the end of 6 months while only 55% in the control group had lost weight in 6 months. Thus A 6-month course of metformin improves menstrual cyclicity in women with the PCOS.Conclusions: In patients with PCOS, the addition of insulin sensitizers viz metformin along with diet and lifestyle modifications has resulted in significant weight loss and improvement in cyclicity of menstrual cycle. Thus, Insulin-sensitizing agents provide a rational approach to the treatment of the metabolic and endocrine abnormalities in PCOS women

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Section: Discussionsupporting

confidence: 88%

PCOS in adolescence: effect of metformin on menstrual irregularities

Sontakke

2017

Int J Reprod Contracept Obstet Gynecol

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“…BMI had weak positive correlation with serum prolactin, serum cholesterol, fasting blood sugar, fasting insulin and insulin resistance ( . However, in two other studies mean age was found 25.6±3.9 and 27±5 years respectively [12][13] . In this series 16 cases were of above 30 years which is comparable to the findings of Sangabathula et al 14 .…”

Section: Resultsmentioning

confidence: 99%

Clinical, Biochemical and Hormonal Profile of Polycystic Ovary Syndrome

Nahar

Mahfuza

Begum

et al. 2018

J. Natl Inst. Neurosci Bangladesh

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Background:The polycystic ovary syndrome is a heterogenous condition, the pathophysiology of which is multifactorial. It is considered as a systemic and metabolic disorder like hyperglycemia and insulin resistance with increased risk of type II diabetes mellitus and cardiovascular diseases. Objective: The purpose of the present study was to analyze the clinical, biochemical and hormonal profile of patients PCOS and to find out correlations among them. Methodology: This cross-sectional observational study was done including 100 diagnosed cases of PCOS attending the GOPD, BSMMU Hospital. This study was done to analyze the clinical, biochemical and hormonal characteristics of PCOS patients and to observe the correlations among them. Result: The mean age of study populations was 22.7± 6.9 years and more than half of them were overweight or obese. Menstrual abnormality like oligomenorrhoea and secondary amenorrhoea was found in 95% cases and 5% were eumenorrhic. Prevalence of hirsutism and subfertility was 69% and 50% respectively. More than half (52%) of cases had LH/FSH ratio >2 which is taken to be significant. About one-third (30%) of cases had total testosterone level above the reference range with a mean value of serum testosterone 71.4±27.9 ng/dL. Conclusion: Significant positive correlation was found among increased BMI, increased LH/FSH ratio, serum testosterone and serum TSH level. Further studies are needed to corroborate our findings and to find out the clinical, biochemical and endocrinological characteristics of our women of PCOS. [Journal of National Institute of Neurosciences Bangladesh, 2017;3(2): 94-98]

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“…The role of androgens in the pathogenesis of acne vulgaris is well known; elevated androgen levels in women with acne have been confirmed in many studies (5)(6)(7)(8)(9)(10)(11)(12)(13). Androgens elevate sebum production and follicular ceratosis, which plays a major role in the etiology of acne (14).…”

Section: Introductionmentioning

confidence: 92%

Exploratory Biochemical Data Analysis: a Comparison of Two Sample Means and Diagnostic Displays

Meloun

Hill²,

Cibula³

2001

Clinical Chemistry and Laboratory Medicine

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The occurrence of acne in women with hyperandrogenemia is well known; a question remains, however, as to whether a further positive relationship can be detected between the intensity of acne and the levels of testosterone, androgen precursors and sex hormone binding globulin (SHBG). A procedure of interactive data analysis extracting relevant information from original data was applied. Exploratory data analysis (EDA) identifies basic statistical features and patterns of data using a variety of diagnostic displays. The need for this step is particularly acute in biochemical and clinical data, the distribution of which is mostly nonGaussian and often corrupted by the outliers. The omission of EDA can lead to incorrect results and false conclusions. In the EDA (i) several graphical tools for summarizing data are applied, (ii) the peculiarities of a sample distribution are investigated, (iii) a construction of distribution is carried out, (iv) a graphical comparison of the sample distribution with selected theoretical distributions is employed. The proposed procedure is illustrated by typical case study in the evaluation of differences between mean values of serum levels of testosterone, androgen precursors and SHBG in a group of patients with mild and severe forms of acne. A knowledge of the interval estimate of the mean value in both groups enables their comparison at the chosen probability level. As will be apparent from the evaluation of inter-group SHBG differences, an incorrect approach to the determination of group mean values could result in a complete misinterpretation of the data. The results indicate that androgens are not significantly related to the intensity of acne, and that SHBG is higher in patients with more severe forms of acne.

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Hormonal Profiles and Prevalence of Polycystic Ovary Syndrome in Women with Acne

Cited by 80 publications

References 19 publications

PCOS in adolescence: effect of metformin on menstrual irregularities

PCOS in adolescence: effect of metformin on menstrual irregularities

Clinical, Biochemical and Hormonal Profile of Polycystic Ovary Syndrome

Exploratory Biochemical Data Analysis: a Comparison of Two Sample Means and Diagnostic Displays

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