Hormonal programming of rat social play behavior: Standardized techniques will aid synthesis and translation to human health

Blake, Bevin E.; McCoy, Krista A.

doi:10.1016/j.neubiorev.2015.04.021

Cited by 18 publications

(11 citation statements)

References 104 publications

(172 reference statements)

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“…This ability to participate in social play is a principal indicator of healthy development (Trezza et al, 2010). Social behaviors are relevant to normal cognitive and social development and have been utilized as behavioral biomarkers for altered development in both rodent models and humans (Blake and McCoy, 2015). Our results suggest that changes in the expression of social play in the offspring is possibly due to the result of developmental retardation and neurological changes produced by the gestational cafeteria diet.…”

Section: Discussionmentioning

confidence: 99%

Cafeteria diet during the gestation period programs developmental and behavioral courses in the offspring

Ribeiro

Batista

Veronesi

et al. 2018

Intl J of Devlp Neuroscience

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The objective of this study was to investigate the effect of exposure to maternal consumption of a hyperenergetic, highly palatable diet, known as the cafeteria diet, during the gestation period on the development and behavior of offspring. For this, we used pregnant female mice that were fed a normal or a cafeteria diet during the gestation period. The evaluation of maternal behavior in lactating dams was performed from the second to the eighth day postpartum (PND 2-8). Weight gain, feed intake, and energy intake were recorded during the gestation period. In the offspring, reflex parameters and physical development were evaluated during the lactation period and when they reached adolescence. Behavioral performance was evaluated in light-dark, open-field, and play behavior tests. In addition, biochemical parameters of the dams and the adolescent offspring were evaluated. The cafeteria diet during gestation altered maternal behavior and the onset of physical and neurodevelopmental landmarks and had an impact on emotional and play behavior in adolescent offspring. In conclusion, our results demonstrate that exposure to maternal consumption of a cafeteria diet during the gestation period can program developmental and behavioral courses in the offspring.

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Section: Discussionmentioning

confidence: 99%

Cafeteria diet during the gestation period programs developmental and behavioral courses in the offspring

Ribeiro

Batista

Veronesi

et al. 2018

Intl J of Devlp Neuroscience

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“…In the 1970s and 1980s, neuroscience was nowhere near as coherent a discipline as it is today and not quite ready to embrace a behavior that, at least on the surface, seemed frivolous, disorganized, and especially hard to quantify. But with the development of easily identifiable and stable behavioral measures that could be used to quantify play in the rat reliably (Blake & McCoy, 2015), more laboratories slowly began to harness the available tools of neuroscience to vigorously study play in rats, and significant progress has been made on identifying the neural circuits responsible for play.…”

Section: Introduction To the Special Issuementioning

confidence: 99%

Saving Tammoland: a microhistory of children’s action to save a wasteground playground, 1965–1968

Keating

2017

International Journal of Play

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“…This ability to participate in social play is a principal indicator of healthy development (Trezza et al, 2010). Social behaviors are relevant to normal cognitive and social development and have been utilized as behavioral biomarkers for altered development in both rodent models and humans (Blake and McCoy, 2015). In fact, deficits in play behavior after neonatal infection and brain injury have already been described as a model of autism (Pletnikov et al, 1999; Lancaster et al, 2007; Kirsten et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats

Carvalho¹,

Ferri

Sousa

et al. 2016

Intl J of Devlp Neuroscience

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Several studies have investigated the effects of artificial litter size adjustment on offspring development. Social play behavior is important for neurobehavioral development and is impaired in several developmental psychiatric disorders. This study therefore investigated the effect of litter size on play behavior in adolescent rats. On postnatal day (PND) 2, litters were adjusted to a small litter (SL) size of 3 pups per dam or normal litter (NL) size of 12 pups per dam. Maternal behaviors scored daily during the first week of lactation (PND2-8) revealed that arched nursing and pup licking behaviors were increased in dams with SLs versus those with NLs. SL offspring exhibited accelerated weight gain and advanced development of physical landmarks and reflexes, possibly due to overnutrition. Social isolation lasting 3.5h prior to social play behavioral testing produced a higher frequency and duration of pouncing, pinning, sniffing, and grooming in both male and female offspring. However, male SL offspring exhibited a lower frequency of pouncing and pinning when compared with male NL offspring, while no litter size-dependent differences were observed in social behaviors unrelated to play (sniffing and grooming). These findings identify a possible sexually dimorphic influence of litter size in the development of social behavior. Given that social behaviors such as play behavior are vital for normal cognitive and social development, these findings have important implications for developmental and neuropsychiatric research.

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Hormonal programming of rat social play behavior: Standardized techniques will aid synthesis and translation to human health

Cited by 18 publications

References 104 publications

Cafeteria diet during the gestation period programs developmental and behavioral courses in the offspring

Cafeteria diet during the gestation period programs developmental and behavioral courses in the offspring

Saving Tammoland: a microhistory of children’s action to save a wasteground playground, 1965–1968

Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats

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