Hormonal regulation of the expression of la antigens on mammary gland epithelium

Klareskog, Lars; Forsum, Urban; Peterson, Per A.

doi:10.1002/eji.1830101212

Cited by 127 publications

(29 citation statements)

References 25 publications

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“…The deployment of the Tac monoclonal antibody to the IL-2 receptor on activated T cells (Uchiyama et al, 1981) might resolve the issue. The variability of expression of HLA-DR on epithelial cells is consistent with previous immunohistological studies of these antigens on human bronchial, intestinal and mammary epithelia (Natali et al, 1981b), where extrinsic factors such as hormonal changes associated with pregnancy and lactation (Klareskog et al, 1980) and the development of graft versus host disease (Lampert et al, 1981;Mason et al, 1981) are influential. The anomalous expression of HLA-DR antigens on solid human tumours is of comparatively more recent description (Natali et al, 1981a;Gatter et al, 1982;Daar et al, 1982;Daar & Fabre, 1983).…”

Section: Monoclonal Antibodiessupporting

confidence: 88%

Expression of major histocompatibility antigens and leucocyte infiltration in benign and malignant human breast disease

Whitwell¹,

Hughes²,

Moore³

et al. 1984

Br J Cancer

101

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Human malignant neoplasms not infrequently reveal mononuclear cell infiltrates which have features in common with immune-associated inflammatory reactions (Underwood, 1974). Although there is limited evidence for tumourrelated functional activity in the infiltrating leucocyte compartment (see Haskill, 1983), the relationship of the phenomenon at a functional or histological level to biological behaviour remains largely obscure.The majority of solid human neoplasms are characterised by marked cellular heterogeneity and any provisional assignment of in situ function will require the elucidation of the heterogeneity and microanatomical distribution of potential leucocytic effector cells relative to the tumour population. Such an analysis must also extend to the neoplastic *Present address:

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Section: Monoclonal Antibodiessupporting

confidence: 88%

Expression of major histocompatibility antigens and leucocyte infiltration in benign and malignant human breast disease

Whitwell¹,

Hughes²,

Moore³

et al. 1984

Br J Cancer

101

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“…Daar et al, 1984b). The so-called 'aberrant expression' of Class II products on normal epithelial cells is associated with immunological, inflammatory as well as hormonal stimuli (Klareskog et al, 1980;Lampert et al, 1981;Mason et al, 1981;Selby et al, 1983) and similar stimuli could promote their expression on malignant epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Expression of MHC products and leucocyte differentiation antigens in gynaecological neoplasms: An immunohistological analysis of the tumour cells and infiltrating leucocytes

Ferguson¹,

Moore²,

Fox³

1985

Br J Cancer

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“…The extent of any similarity with the expression of these determinants on human bronchial, intestinal and mammary epithelia (Natali et al, 1981) -where extrinsic factors such as hormonal changes associated with pregnancy and lactation (Klareskog et al, 1980) and the development of graft versus host disease (Lampert et al, 1981;Mason et al, 1981) are influential -is presently unknown. DR antigen could conceivably augment tumour-associated T cell immune responses (Thompson et al, 1982;Guerry et al, 1984) and there is currently much interest in the observation that cytotoxic cells of T4 phenotype are restricted by Class II determinants (Reinherz et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Distribution of histocompatibility and leucocyte differentiation antigens in normal human colon and in benign and malignant colonic neoplasms

Csiba¹,

Whitwell²,

Moore³

1984

Br J Cancer

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Summary Monoclonal antibodies (McAbs) directed against the framework determinants of Class I and Class II products of the major histocompatibility complex (MHC) and against leucocyte differentiation antigens were used in an indirect immunoperoxidase technique to study their expression in normal, benign (adenomatous polyps) and malignant disease of the colon. Class I products (detected by the McAb 2AI) were strongly expressed on all cell types in normal and benign tissues but some carcinomas exhibited a heterogenous pattern of epithelial cell staining and 4/15 were completely negative. Class II products (detected by TDR3 1.1) were strongly expressed on cells (mainly B lymphocytes) within the lamina propria. In carcinomas TDR31.1 staining was mainly interstitial, but in 2/15, DR+ epithelial cells were also detected. In normal and benign tissues, leucocytes (reactive with 2D1) found predominantly in the lamina propria, comprised T cells mainly of the helper/inducer (OKT4) subset, DR+ cells in approx. equivalent proportion and a few OKM1+ cells mostly of macrophage morphology. Occasional intraepithelial lymphocytes were of cytotoxic/suppressor (OKT8) phenotype. In malignant neoplasms, there was wide inter and intra-tumour variation in the proportion of leucocytes which were heterogeneous with respect to cell type and confined mainly to the stroma. T cells were consistently predominant, but B cells and macrophages were also present. Two neoplasms showed unequivocal evidence of a shift (relative to peripheral blood) in favour of the OKT8+ subset, but in the majority of tumours OKT4+; and OKT8+ cells were present in roughly similar proportions. Natural killer cells (monitored with Leu7, HNK1) were virtually undetectable in both normal and malignant tissues. There were no apparent correlations between the extent and type of leucocyte infiltration, tumour differentiation or expression of MHC products. Some implications for the extrapolation of in vitro data on leucocyte function to the in vivo situation are discussed.

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Hormonal regulation of the expression of la antigens on mammary gland epithelium

Cited by 127 publications

References 25 publications

Expression of major histocompatibility antigens and leucocyte infiltration in benign and malignant human breast disease

Expression of major histocompatibility antigens and leucocyte infiltration in benign and malignant human breast disease

Expression of MHC products and leucocyte differentiation antigens in gynaecological neoplasms: An immunohistological analysis of the tumour cells and infiltrating leucocytes

Distribution of histocompatibility and leucocyte differentiation antigens in normal human colon and in benign and malignant colonic neoplasms

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