Hormone dependent uterine epithelial-stromal communication for pregnancy support

Wang, Xiaoqiu; Wu, San‐Pin; DeMayo, Francesco J.

doi:10.1016/j.placenta.2017.07.003

Cited by 55 publications

(35 citation statements)

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“…Another factor that modified the dendritic spine number is hormones (for review see Frankfurt & Luine, ). During pregnancy, estrogen and progesterone in high levels are present (for review see Berkane et al, ; Frankfurt & Luine, ; Wang, Wu, & DeMayo, ) In addition, these two hormones also exhibited a neuroprotective effect on the PFC and hippocampus (for review see Frankfurt & Luine, ). Accordingly, the hippocampus has high levels of estrogen receptors, which may have a critical role in the estrous cycle and pregnancy (for review see Frankfurt & Luine, ).…”

Section: Discussionmentioning

confidence: 99%

Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

Flores-Vivaldo

Camacho-Ábrego

Picazo

et al. 2019

Synapse

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Pregnancy is a complex process, involving a number of hormones and trophic factors, many of which are formed in the placenta. Several of these trophic factors have an effect at the neuronal level, such as BDNF. Consequently, recent reports have shown that exposure to these hormones (estrogen and progesterone) and trophic factors such as BDNF exert a neuroprotective effect. Here, we study the effect of the number of pregnancies on dendritic morphology of aged female rats (18 months of age). Rats of the 18‐month‐old Sprague Dawley strain with zero, one, two, and three gestations were evaluated for locomotor activity, and Golgi–Cox stain was performed to evaluate the dendritic morphology parameters, the number of dendritic spines, total dendritic length, and branching order number. Adult nulliparous rats (3 months of age) were used as another control group. Adult nulliparous and aging rats with two pregnancies showed an increase in locomotor activity. Adult nulliparous showed an increase in the dendritic spine number compared to old nulliparous rats in both layers of the PFC, the DG, and NAcc. Old rats with two and three pregnancies also showed an increase in the number of dendritic spines compared to old nulliparous rats in layers 3 and 5 of the PFC and in the CA1. Aging animals with one pregnancy also showed an increase in dendritic length compared to old nulliparous rats in the CA1. Our results clearly suggest that two and three pregnancies increase the dendritic spines number in the PFC and CA1 of aged female rats.

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Section: Discussionmentioning

confidence: 99%

Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

Flores-Vivaldo

Camacho-Ábrego

Picazo

et al. 2019

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“…In silico analysis of caprine, ovine and bovine FOXL2 promoter sequences confirmed the presence of a PRE motif that suggests regulation of FOXL2 gene expression by P4 [68,69]. The association of P4 with PGR affects the expression of numerous transcription factors, including FOXO1, HOXA10 or HAND2 [38], which are involved in cell differentiation and secretory protein production in the uterus [70]. The interaction between P4 and FOXL2 expression was further evidenced using a COS7 cell line overexpressing PGR protein where P4 supplementation activated the FOXL2 promoter.…”

Section: Discussionmentioning

confidence: 78%

“…The biological actions of E2 and P4 are mainly mediated by their nuclear receptors, Estrogen Receptor (ESR1-2, formerly named ERα-β, transcribed from two distinct genes) and Progesterone nuclear Receptor (PGRA-B, two isoforms from the same gene; [15,35]), respectively. Upon binding with E2 or P4, the receptors translocate to the nucleus and modulate expression of E2 or P4 target genes [15,[35][36][37][38]. In the last decade, studies have identified direct target genes of ESR and PGR in humans, rodents and cattle [39].…”

Section: Introductionmentioning

confidence: 99%

“…In the last decade, studies have identified direct target genes of ESR and PGR in humans, rodents and cattle [39]. These genes are involved in the repression of the E2 signalling pathway (NR2F2/COUP-TFII; [38]), proliferation of endometrial cells (i.e., IGF1 and EGR1; [35,38]), uterine receptivity (FOXO1, [40]) and decidualisation (NR2F2/COUP-TFII, WNT4, HOXA10; [38]). This non-exhaustive list of steroids targeting genes in the endometrium includes transcription factors that represent regulation nodes of endometrial receptivity and physiology.…”

Section: Introductionmentioning

confidence: 99%

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FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants

Eozénou

Lesage-Padilla

Mauffré

et al. 2020

IJMS

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Forkhead Box L2 (FOXL2) is a member of the FOXL class of transcription factors, which are essential for ovarian differentiation and function. In the endometrium, FOXL2 is also thought to be important in cattle; however, it is not clear how its expression is regulated. The maternal recognition of pregnancy signal in cattle, interferon-Tau, does not regulate FOXL2 expression. Therefore, in the present study, we examined whether the ovarian steroid hormones that orchestrate implantation regulate FOXL2 gene expression in ruminants. In sheep, we confirmed that FOXL2 mRNA and protein was expressed in the endometrium across the oestrous cycle (day 4 to day 15 post-oestrus). Similar to the bovine endometrium, ovine FOXL2 endometrial expression was low during the luteal phase of the oestrous cycle (4 to 12 days post-oestrus) and at implantation (15 days post-oestrus) while mRNA and protein expression significantly increased during the luteolytic phase (day 15 post-oestrus in cycle). In pregnant ewes, inhibition of progesterone production by trilostane during the day 5 to 16 period prevented the rise in progesterone concentrations and led to a significant increase of FOXL2 expression in caruncles compared with the control group (1.4-fold, p < 0.05). Ovariectomized ewes or cows that were supplemented with exogenous progesterone for 12 days or 6 days, respectively, had lower endometrial FOXL2 expression compared with control ovariectomized females (sheep, mRNA, 1.8-fold; protein, 2.4-fold; cattle; mRNA, 2.2-fold; p < 0.05). Exogenous oestradiol treatments for 12 days in sheep or 2 days in cattle did not affect FOXL2 endometrial expression compared with control ovariectomized females, except at the protein level in both endometrial areas in the sheep. Moreover, treating bovine endometrial explants with exogenous progesterone for 48h reduced FOXL2 expression. Using in vitro assays with COS7 cells we also demonstrated that progesterone regulates the FOXL2 promoter activity through the progesterone receptor. Collectively, our findings imply that endometrial FOXL2 is, as a direct target of progesterone, involved in early pregnancy and implantation.

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“…PGRB is a gene activator that is dependent on P4, whereas PGRA is a weak gene activator that acts as a potent inhibitor of PGRB, thereby reducing the effects of P4 (Pieber, Allport, & Bennett, 2001). ESR are transcribed from two genes: ESR1 and ESR2 (Wang, Wu, & DeMayo, 2017). Uterine receptivity to implantation is P4 dependent; however, implantation events are preceded by loss of gene expression of PGR and ESR1 by bovine uterine epithelia (Bazer et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Profiles of maternal origin factors during transition from embryonic diapause to implantation in roe deer

Korzekwa

Kotlarczyk

Zadroga

2019

Animal Science Journal

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The aim was to evaluate in female roe deer: (a) PAG mRNA relative abundance in endometrial uterine tissue for determination of the duration of embryonic diapause, (b) mRNA relative abundance of progesterone, estradiol, and prolactin (P4, E2, and PRL) receptors (PGR, ESR, and PRLR) during diapause and after implantation in the endometrium; (c) concentration of P4, E2, and PRL in the blood, and (d) a noninvasive method of hormone detection by measurement of P4 and E2 concentrations in feces. A total of fifteen individuals were obtained post mortem during hunting seasons and divided into three experimental groups (November, December, January). The results did not reveal mRNA relative abundance for PAGs in the endometrium or detectable PAG concentrations in the serum of all examined females. Concentration of PRL and mRNA relative abundance for PRLR long isoform in the endometrium was the highest in January (p < .01). mRNA relative abundance for PGR, P4 concentration in the endometrium, serum, and feces was the highest in January (p < .01). Endometrial origin PRL and P4 may be responsible for the termination of this process and pregnancy development after implantation.

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Hormone dependent uterine epithelial-stromal communication for pregnancy support

Cited by 55 publications

References 100 publications

Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants

Profiles of maternal origin factors during transition from embryonic diapause to implantation in roe deer

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