Hormones and Muscle Atrophy

Martín, Ana Isabel Morales; Priego, Teresa; López-Calderón, Asunción

doi:10.1007/978-981-13-1435-3_9

Cited by 55 publications

(43 citation statements)

References 172 publications

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“…Components of the endocrine system, such as growth hormone (GH), insulin-like growth factor-1 (IGF-1), and androgens, are the foremost regulators of muscle metabolism. These endocrine components have substantial impacts on muscle and act as anabolic factors and significant regulators of muscle mass [28]. IGF-1 is a 70 aa polypeptide with autocrine, paracrine, and endocrine properties, and shares a~60% similarity with IGF-2 and a 50% similarity with proinsulin structures [29].…”

Section: Introductionmentioning

confidence: 99%

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Ahmad

Lee

et al. 2020

Cells

117

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Skeletal muscle is an essential tissue that attaches to bones and facilitates body movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an important role in skeletal myogenesis and is importantly associated with muscle mass entity, strength development, and degeneration and increases the proliferative capacity of muscle satellite cells (MSCs). IGF-1R is an IGF-1 receptor with a transmembrane location that activates PI3K/Akt signaling and possesses tyrosine kinase activity, and its expression is significant in terms of myoblast proliferation and normal muscle mass maintenance. IGF-1 synthesis is elevated in MSCs of injured muscles and stimulates MSCs proliferation and myogenic differentiation. Mechanical loading also affects skeletal muscle production by IGF-1, and low IGF-1 levels are associated with low handgrip strength and poor physical performance. IGF-1 is potentially useful in the management of Duchenne muscular dystrophy, muscle atrophy, and promotes neurite development. This review highlights the role of IGF-1 in skeletal muscle, its importance during myogenesis, and its involvement in different disease conditions.

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Section: Introductionmentioning

confidence: 99%

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Ahmad

Lee

et al. 2020

Cells

117

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“…Sepsis, especially severe sepsis, can lead to a significant decrease in serum testosterone levels in either patients or experimental animals, which is currently thought to be caused by the suppression of the hypothalamic-pituitary-gonadal axis by systemic inflammatory response syndrome [17]. In view of the powerful role of testosterone in enhancing exercise endurance, we wondered whether testosterone can improve the symptoms of muscle atrophy following sepsis.…”

Section: Discussionmentioning

confidence: 99%

Testosterone improves muscle function of the extensor digitorum longus in rats with sepsis

Wang

2020

Bioscience Reports

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Among patients with intensive care unit-acquired weakness (ICUAW), skeletal muscle strength often decreases significantly. The present study aimed to explore the effects of testosterone propotionate on skeletal muscle using rat model of sepsis. Male SD rats were randomly divided into experimental group, model control group, sham operation group and blank control group. Rats in experimental group were given testosterone propionate two times a week, 10 mg/kg for 3 weeks. Maximal contraction force, fatigue index and cross-sectional area of the extensor digitorum longus (EDL) were measured. Myosin, IGF-1, p-AKT and p-mTOR levels in EDL were detected by Western blot. Histological changes of the testis and prostate were detected by hematoxylin and eosin staining. We found that maximal contraction force and fatigue index of EDL in experimental group were significantly higher than in model control group. Cross-sectional area of fast MHC muscle fiber of EDL in group was significantly higher than in model control group. The levels of myosin, IGF-1, p-AKT and p-mTOR of EDL in experimental group were significantly higher than in model control group. In addition, no testicle atrophy and prostate hyperplasia were detected in experimental group. In conclusion, these results suggest that testosterone propionate can significantly improve skeletal muscle strength, endurance and volume of septic rats, and the mechanism may be related to the activation of IGF-1/AKT pathway. Moreover, testosterone propionate with short duration does not cause testicular atrophy and prostate hyperplasia in septic rats. Therefore, testosterone propionate is a potential treatment for muscle malfunction in ICUAW patients.

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“…Sepsis, especially severe sepsis, can lead to a significant decrease in serum testosterone levels in either patients or experimental animals, which is currently thought to be caused by 1 1 the suppression of the hypothalamic-pituitary-gonadal axis by systemic inflammatory response syndrome. 17 In view of the powerful role of testosterone in enhancing exercise strength and endurance, we wondered whether testosterone can improve the symptoms of muscle atrophy following sepsis.…”

Section: Discussionmentioning

confidence: 99%

Testosterone improves muscle function of the extensor digitorum longus in rats with sepsis

Jinlong

2019

Preprint

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Among patients with Intensive care unit-acquired weakness (ICUAW), skeletal muscle strength often decreases significantly. This study aimed to explore the effects of testosterone propionate on skeletal muscle using rat model of sepsis. Male SD rats were randomly divided into experimental group, model control group, sham operation group and blank control group.Rats in experimental group were given testosterone propionate 2 times a week, 10 mg/kg for 3 weeks. Maximal contraction force, fatigue index and cross-sectional area of the extensor digitorum longus (EDL) were measured. Myosin, IGF-1, p-AKT and p-mTOR levels in EDL were detected by Western blot. Histological changes of the testis and prostate were detected by hematoxylin and eosin staining. We found that maximal contraction force and fatigue index of EDL in experimental group were significantly higher than in model control group.Cross sectional area of fast MHC muscle fiber of EDL in group was significantly higher than in model control group. The levels of myosin, IGF-1, p-AKT and p-mTOR of EDL in experimental group were significantly higher than in model control group. In addition, no testicle atrophy and prostate hyperplasia was detected in experimental group. In conclusion, these results suggest that testosterone propionate can significantly improve skeletal muscle strength, endurance and volume of septic rats, and the mechanism may be related to the activation of IGF-1/AKT pathway. Moreover, testosterone propionate with short duration does not cause testicular atrophy and prostate hyperplasia in septic rats. Therefore, testosterone propionate is a potential treatment for muscle malfunction in ICUAW patients.

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Hormones and Muscle Atrophy

Cited by 55 publications

References 172 publications

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Testosterone improves muscle function of the extensor digitorum longus in rats with sepsis

Testosterone improves muscle function of the extensor digitorum longus in rats with sepsis

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