Hormones and the auditory system: A review of physiology and pathophysiology

Al-Mana, Deena; Ćeranić, Borka; Djahanbakhch, O.; Luxon, Linda M.

doi:10.1016/j.neuroscience.2008.02.077

Cited by 109 publications

(86 citation statements)

References 205 publications

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“…As different attention conditions were used, resulting in either LEAs or REAs, it is unlikely that the general reduction in language lateralisation is due to sex hormones selectively affecting one hemisphere. It is also rather speculative that estradiol and/or progesterone modulated the efficacy of the ipsilateral/contralateral projections from the non-dominant/dominant ear to the right/left auditory cortices because sex hormonal effects on subcortical auditory pathways are not known (Al-Mana et al, 2008). We are therefore inclined to believe that the observed reduction in condition-specific DL biases occurred on the cortical level.…”

Section: Discussionmentioning

confidence: 99%

Sex hormones affect language lateralisation but not cognitive control in normally cycling women

Hodgetts

Weis

Hausmann

2015

Hormones and Behavior

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(2015) 'Sex hormones aect language lateralisation but not cognitive control in normally cycling women. ', Hormones and behavior., Further information on publisher's website:https://doi.org/10.1016/j.yhbeh.2015.06.019Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in Hormones and behavior. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reected in this document. Changes may have been made to this work since it was submitted for publication. A denitive version was subsequently published in Hormones and behavior, 74, August 2015, 10.1016/j.yhbeh.2015 Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractNatural fluctuations of sex hormones during the menstrual cycle have been shown to modulate language lateralisation. Using the dichotic listening (DL) paradigm, a wellestablished measurement of language lateralisation, several studies revealed that the left hemispheric language dominance was stronger when levels of estradiol were high. A recent study (Hjelmervik et al., 2012) showed, however, that high levels of follicular estradiol increased lateralisation only in a condition that required participants to cognitively control (top-down) the stimulus-driven (bottom-up) response. This finding suggested that sex hormones modulate lateralisation only if cognitive control demands are high. The present study investigated language lateralisation in 73 normally cycling women under three attention conditions that differed in cognitive control demands. Saliva estradiol and progesterone levels were determined by luminescence immunoassays. Women were allocated to a high or low estradiol group. The results showed a reduced language lateralisation when estradiol and progesterone levels were high. The effect was independent of the attention condition indicating that estradiol marginally affected cognitive control. The findings might suggest that high levels of estradiol especially reduce the stimulus-driven (bottom-up) aspect of lateralisation rather than top-down cognitive control.

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Section: Discussionmentioning

confidence: 99%

Sex hormones affect language lateralisation but not cognitive control in normally cycling women

Hodgetts

Weis

Hausmann

2015

Hormones and Behavior

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“…clinical studies it has been shown that different kinds of stress (such as overall stress, emotional stress, and posttraumatic stress disorder) can intensify sudden hearing loss or tinnitus in humans (Ban and Jin, 2006;Hinton et al, 2006;Fagelson, 2007;Hebert and Lupien, 2007;Al Mana et al, 2008); in general, however, the affected frequency range was not the focus of these studies. Tinnitus occurs mostly as high-pitch, but can also occur as lowpitch, ringing.…”

Section: Discussionmentioning

confidence: 99%

Urocortin‐expressing olivocochlear neurons exhibit tonotopic and developmental changes in the auditory brainstem and in the innervation of the cochlea

Kaiser¹,

Alexandrova

Grothe³

2011

J of Comparative Neurology

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The mammalian cochlea is under direct control of two groups of cholinergic auditory brainstem neurons, the medial and the lateral olivocochlear neurons. The former modulate the electromechanical amplification in outer hair cells and the latter the transduction of inner hair cells to auditory nerve fibers. The lateral olivocochlear neurons express not only acetylcholine but a variety of co-transmitters including urocortin, which is known to regulate homeostatic responses related to stress; it may also be related to the ontogeny of hearing as well as the generation of hearing disorders. In the present study, we investigated the distribution of urocortin-expressing lateral olivocochlear neurons and their connectivity and distribution of synaptic terminals in the cochlea of juvenile and adult gerbils. In contrast to most other rodents, the gerbil's audiogram covers low frequencies similar to humans, although their communication calls are exclusively in the high-frequency domain. We confirm that in the auditory brainstem urocortin is expressed exclusively in neurons within the lateral superior olive and their synaptic terminals in the cochlea. Moreover, we show that in adult gerbils urocortin expression is restricted to the medial, high-frequency processing, limb of the lateral superior olive and to the mid and basal parts of the cochlea. The same pattern is present in juvenile gerbils shortly before hearing onset (P 9) but transiently disappears after hearing onset, when urocortin is also expressed in low-frequency processing regions. These results suggest a possible role of urocortin in late cochlear development and in the processing of social calls in adult animals.

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“…Changes in auditory function during the ovarian cycle may also occur (Walpurger et al, 2004;Al-Mana et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Alteration in auditory function during the ovarian cycle

et al. 2010

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Hormones and the auditory system: A review of physiology and pathophysiology

Cited by 109 publications

References 205 publications

Sex hormones affect language lateralisation but not cognitive control in normally cycling women

Sex hormones affect language lateralisation but not cognitive control in normally cycling women

Urocortin‐expressing olivocochlear neurons exhibit tonotopic and developmental changes in the auditory brainstem and in the innervation of the cochlea

Alteration in auditory function during the ovarian cycle

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