Hormônio do crescimento humano e a perspectiva futura em Odontologia

Pagnoncelli, Rogério Miranda; Gerzson, Alexandre da Silveira; Camilotti, Renata Stifelman; Jasper, Juliana; Boing, Fernanda

doi:10.5335/rfo.v19i3.3613

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…[9] The tomography obtained from the region showed that there was adequate bone density, making the site fit to receive osseintegrated implant. rhGH, used in other studies, seems to be a promising growth factor for application in the maxillofacial area and may add important characteristics to the materials usually used for bone reconstruction, [4,10] in this case, it was used for socket bone preservation and early maturation of the bone.…”

Section: Discussionmentioning

confidence: 99%

Socket Preservation using Human Recombinant Growth Hormone Associated with Bio-Oss Biomaterial with the Purpose of Improving Healing and Reducing Treatment Time - A Case Report

Giacomin¹,

Warmeling²,

Silva³

et al. 2019

J Clin Res Dent

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The purpose of this article is to describe a clinical case where recombinant human growth hormone (rhGH) associated with Bio-Oss  was used in socket preservation. 53-year-old female patient, ASA I, attended the dental clinic presenting a root fracture of the second upper right premolar. The treatment plan consisted of tooth removal and socket preservation with rhGH and Bio-Oss. After 4 months, a tomography scan was performed before implant placement. At the time of the implant placement, a bone sample was sent for histological analysis. The collected material was analyzed histologically and demonstrated mature bone, with areas of neoformation and deposition of bone matrix and the tomographic aspect was of a hypodense image inside the socket. Socket preservation realized with rhGH associated with Bio-Oss  was able to maintain the three-dimensional dimensions of the sockets, promoting neoformed bone with histological and radiographic features of maturation and was able to reduce the time of treatment.

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Section: Discussionmentioning

confidence: 99%

Socket Preservation using Human Recombinant Growth Hormone Associated with Bio-Oss Biomaterial with the Purpose of Improving Healing and Reducing Treatment Time - A Case Report

Giacomin¹,

Warmeling²,

Silva³

et al. 2019

J Clin Res Dent

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“…O hormônio do crescimento, quando utilizado em altas dosagens (níveis suprafisiológicos) e por longo tempo, pode induzir a disfunção hepática, hipertrigliricemia, hipoglicemia e acromegalia. Entretanto, nenhum estudo mostrou qualquer efeito adverso, quando utilizado no âmbito da odontologia [25][26][27][28] .…”

Section: Somatropinaunclassified

Uso do hormônio do crescimento associado à fibrina rica em plaquetas e leucócitos injetável (I-PRF)

Silva

Giacomin

Warmeling

et al. 2019

Rev. da Fac. de Odontologia, UPF

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Objetivo: demonstrar, por meio de uma revisão de literatura, a utilização do hormônio do crescimento (GH) e concentrados plaquetários e sugerir técnica de associação de uso para odontologia em processos de preservação de osso alveolar. Revisão de literatura: enxertos ósseos são uma necessidade na área da saúde, por diversas razões. A utilização de osso autógeno apresenta grande desvantagem em ter um segundo sítio cirúrgico, entretanto, os substitutos ósseos não possuem as características ideais. Assim, existe a busca por alternativas que otimizem a cicatrização e a incorporação dos substitutos ósseos, dentre elas os concentrados sanguíneos, ricos em fatores de crescimento derivados das plaquetas e o hormônio do crescimento. É possível encontrar uma vasta literatura utilizando os concentrados sanguíneos, inclusive utilizando esses como veículos para outras substâncias. Os concentrados sanguíneos são ricos em fatores de crescimento derivados das plaquetas, como fator de crescimento semelhante à insulina (IGF), Fator de crescimento derivado de plaquetas (PDGF) e outros. Além disso, também é possível encontrar, na literatura, o uso tópico de hormônio do crescimento em enxertos ósseos, fraturas e implantes dentários. Entretanto, o GH possui uma meia-vida de 20 minutos, assim, quando utilizado em conjunto com a I-PRF, espera-se um aumento no tempo de ação local. Considerações finais: é possível otimizar os enxertos ósseos utilizando-se L-PRF/I-PRF e hormônio do crescimento. Porém, são necessárias mais pesquisas.

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“…4 Therefore, some mechanisms used in the treatment of bone defects correspond to autologous, allogeneic or xenotransplantation transplants. However, these methods require strict control associated to the transmission of infectious agents.…”

Section: 3mentioning

confidence: 99%

Osteogenic potential of different chalcones in an in vivo model: A preliminary study.

et al. 2017

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Aim. To evaluate the osteogenic potential of chalcones using the rat critical size calvarial defect. Methods. The chalcones were synthesized from acetophenone following the Claisen-Schmidt aldol condensation method by varying the substituted benzaldehydes (3,4-Cl; 4-Cl; 4-CH 3 ; 4-OCH 3 , H). The five chalcone molecules were evaluated in three concentrations (1%, 5% and 10%) in comparison to control and vehicle (Vaseline) groups. The results of the remaining wound areas were calculated statistically by the ANOVA method followed by the Student-Newman-Keuls test and the histological sections were analyzed qualitatively by light microscopy. Results. All molecules at 10% concentration showed significant bone closure compared to the control, vehicle and chalcone groups at 1% concentration (p<0.01). Active osteoblasts were observed on the repair surfaces in all groups treated with chalcones. Treatment with the C5 molecule at concentration of a 10% resulted in greater bone neoformation compared to the other molecules, with features of secondary bone observed. Conclusion. The chalcones evidenced a dose-dependent osteogenic potential and C5 was more effective in bone repair.

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Hormônio do crescimento humano e a perspectiva futura em Odontologia

Cited by 4 publications

References 25 publications

Socket Preservation using Human Recombinant Growth Hormone Associated with Bio-Oss Biomaterial with the Purpose of Improving Healing and Reducing Treatment Time - A Case Report

Socket Preservation using Human Recombinant Growth Hormone Associated with Bio-Oss Biomaterial with the Purpose of Improving Healing and Reducing Treatment Time - A Case Report

Uso do hormônio do crescimento associado à fibrina rica em plaquetas e leucócitos injetável (I-PRF)

Osteogenic potential of different chalcones in an in vivo model: A preliminary study.

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